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Monoclonal antibodies to the components of the high-molecular-mass aminoacyl-tRNA synthetase complex.

Filonenko, V V; Wolfson, A D; Wartanyan, O A; Beresten, S F.

Biomed Sci ; 2(3): 289-92, 1991.

Article in English | MEDLINE | ID: mdl-1721551

ABSTRACT

Six monoclonal antibodies to the components of the rabbit multienzyme aminoacyl-tRNA synthetase complex were generated and characterised. Two, F7 and F31 were directed against arginyl-tRNA synthetase, two, F8 and F25 against glutamyl-tRNA synthetase, and two, F6 and F12 recognised 38 and 43 kDa polypeptides, respectively. All antibodies were species-specific and failed to affect the activity of the respective enzymes.

Subject(s)

Amino Acyl-tRNA Synthetases/immunology , Antibodies, Monoclonal/chemistry , Multienzyme Complexes/immunology , Amino Acyl-tRNA Synthetases/chemistry , Animals , Antibody Specificity , Epitopes/immunology , Glutamate-tRNA Ligase/chemistry , Glutamate-tRNA Ligase/immunology , Mice , Mice, Inbred BALB C , Molecular Weight , Multienzyme Complexes/chemistry , Peptide Mapping , Rabbits

ABSTRACT

Subject(s)

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