ABSTRACT
The occurrence of fibroelastic papilloma arising in a Chiari network in an 85-year-old man is described. Occurrence of this tumor in this location has not been previously reported, and should be added to the differential diagnosis of intracardiac masses arising in the right atrium.
Subject(s)
Fibroma/pathology , Heart Neoplasms/pathology , Papilloma/pathology , Aged , Aged, 80 and over , Diagnosis, Differential , Heart Atria , Humans , Male , Vena Cava, InferiorABSTRACT
We report on an individual with Kallman syndrome (KS) and a balanced de novo translocation (7;12)(q22,q24). None of 6 full sibs, 3 half-sibs, or parents have KS or this chromosome translocation. This is the only known report of KS with a chromosome abnormality. This may represent a spurious association or genetic heterogeneity vis-a-vis the reported linkage of KS to the steroid sulphatase gene on the X chromosome. The pathophysiology and genetics of KS are discussed.
Subject(s)
Chromosomes, Human, Pair 12 , Chromosomes, Human, Pair 7 , Hypogonadism/genetics , Olfaction Disorders/genetics , Translocation, Genetic , Adult , Bone and Bones/abnormalities , Cells, Cultured , Humans , Karyotyping , Male , Olfactory Nerve/abnormalities , SyndromeABSTRACT
A patient with a de novo duplication of 17p is described. A comparison with five other published cases indicates several features in common that seem characteristic of the syndrome. Primary features include, low birth weight, small size, severe mental and motor retardation, heart defect, failure to thrive and peculiar facial traits. The prominent facial features are, a tendency for round and flat mid face, small palpebral fissures, hypertelorism, microcephaly and low set prominent ears.
Subject(s)
Chromosomes, Human, Pair 17 , Trisomy , Abnormalities, Multiple/genetics , Chromosome Banding , Female , Humans , Infant, Newborn , Karyotyping , Lymphocytes/cytology , Male , SyndromeABSTRACT
Wolf syndrome has been recognized since the mid-sixties. It has also been postulated that the loss of 4p16 is the primary reason for the syndrome. However, in a handful of cases the breakpoints have been identified, only a very few of which are exclusively 4p16. In this report we present familial transmission of 4p16 deletion (associated with 8pter----8p21 duplication) in three individuals with typical expression of Wolf syndrome. The transmission occurs from a de novo balanced maternal translocation, 46,XX,t(4;8)(p16;p21). An effort has also been made to distinguish the terminal deletion syndrome from the emerging interstitial deletion syndrome of 4p.
Subject(s)
Abnormalities, Multiple/genetics , Chromosome Deletion , Chromosomes, Human, Pair 4 , Chromosome Banding , Chromosomes, Human, Pair 8 , Humans , Intellectual Disability/genetics , Male , Pedigree , Syndrome , Translocation, GeneticABSTRACT
Duplication of 6q24 leads to 6qter was identified by GTG banding in an infant girl whose father was a balanced translocation carrier 46,XY,t(3;6)(p26 leads to q2402). At birth and at 4 mo she had proportionate short stature, microcephaly, asymmetric micrognathia, bow-shaped upper vermilion, long upper lip, submucous cleft palate, antimongoloid slant of palpebral fissures, telecanthus, prominent eyes, short neck with anterior and lateral webbing, short sternum, overlapping toes, wrist contractures, and hypertonicity. Later she was noted to have psychomotor retardation. Eleven previously published cases and our patient suggest that duplication of 6q (involving at least 6q25 leads to 6qter) produces a highly characteristic syndrome.
Subject(s)
Abnormalities, Multiple/genetics , Chromosome Aberrations , Chromosomes, Human, 6-12 and X , Intellectual Disability/genetics , Translocation, Genetic , Chromosome Banding , Female , Growth Disorders/genetics , Humans , Infant, Newborn , Karyotyping , Lymphocytes/ultrastructure , Male , SyndromeABSTRACT
Quantitative studies of erythrocyte acid phosphatase (ACP1) and soluble malate dehydrogenase (MDH1), both assigned to distal chromosome 2p, were performed by colorimetric methods on the red cells of four patients in an attempt to demonstrate a gene dosage effect. The patients inherited the unbalanced form of a familial reciprocal translocation, t(2;10)(p24;q26), and had partial duplication 2p. Parents of all patients and siblings of some were included in the study. All patients had increased levels of ACP1 corresponding to the presence of three structural genes. Levels of MDH1 were not increased. Evidence shows that the ACP1 gene is in the region 2p24 leads to 2pter and that MDH is not.
Subject(s)
Acid Phosphatase/genetics , Chromosomes, Human, 1-3 , Erythrocytes/enzymology , Gene Expression Regulation , Genes , Malate Dehydrogenase/genetics , Translocation, Genetic , Acid Phosphatase/blood , Chromosome Mapping , Female , Humans , Malate Dehydrogenase/blood , Male , Pedigree , PhenotypeABSTRACT
We describe a familial reciprocal translocation between the distal part of the short arm of chromosome 2 and the long arm of chromosome 10. Five individuals in two generations had multiple congenital anomalies. Their karyotypes were 46,XX or XY, -10, + der(10), t(2;10)(p24;q26). Seven persons were balanced translocation carriers whose karyotypes were 46,XX or XY,t(2;10)(p24;q26). Common manifestations included mental retardation, strabismus, narrow high-arched palate, wide alveolar ridges, other facial abnormalities, genital abnormalities and mutism. The phenotype of the unbalanced individuals is compared to that of previously published cases of the syndrome of partial duplication 2p and to reported patients with partial deletion of 10q.
Subject(s)
Abnormalities, Multiple/genetics , Chromosome Deletion , Chromosomes, Human, 1-3 , Chromosomes, Human, 6-12 and X , Translocation, Genetic , Adult , Child, Preschool , Dermatoglyphics , Female , Heterozygote , Humans , Infant, Newborn , Intellectual Disability/genetics , Karyotyping , Male , Mutism/genetics , PedigreeABSTRACT
This is the first report of the simultaneous occurrence of mucinous carcinoid and endometriosis in an inside-out appendix. The literature concerning carcinoids, endometriosis and intussusception of the appendix is reviewed. The mucinous, or goblet cell carcinoid was positive for mucin, argentaffin and argyrophil stains. Paneth cells were present. Two and one-half years with no tumor recurrence suggest good prognosis as previously reported.
Subject(s)
Appendiceal Neoplasms/complications , Carcinoid Tumor/complications , Endometriosis/complications , Intussusception/complications , Adult , Appendiceal Neoplasms/pathology , Carcinoid Tumor/pathology , Endometriosis/pathology , Female , Humans , Intussusception/surgery , Leiomyoma/complications , Uterine Neoplasms/complicationsABSTRACT
Chromosome analysis of an infant with characteristic features of trisomy 18 is presented. The chromosome complement contained a modal count of 47 but there was only one No. 18. In addition, there were two metacentric chromosomes of different sizes. The two metacentric chromosomes were identified by G- and C-banding to be possible isochromosomes of the long and short arms of a No. 18 chromosome.
Subject(s)
Chromosomes, Human, 16-18 , Trisomy , Azure Stains , Chromosomes/ultrastructure , Chromosomes, Human , Female , Follow-Up Studies , Humans , Infant , Infant, Newborn , KaryotypingABSTRACT
A newly described partial trisomy of the short arm of chromosome number 7 is reported in a familial translocation between 7 and 22. The unbalanced translocation was found in one family member, the propositus, and the balanced form in 5 other members. The possibility of this translocation being a rare telomeric attachment previously undescribed in humans is discussed. Prominent clinical features include general mental and motor retardation, microbrachycephaly, and cardiac and oral abnormalities.