Assessment of Well-Being Across Menstrual Phases in Female Students.

Purpose: In this study, we determined female nursing students' physical and mental state involvement by measuring heart rate variability and salivary α-amylase activity (αAMY). Methods: The study included 108 students aged 20-21 with regular menstrual cycles. The basal body temperature method was used to determine the menstrual phases. Five indices were used: low and high frequency components, and their ratio, total power, and physical stress index. In addition, αAMY was measured using a salivary amylase monitor. A six-point scale was used for subjective mood evaluation. Repeated measures analysis of variance was performed for differences between groups, and the Tukey-Kramer method was used for multiple comparisons. A p-value of <0.05 was considered statistically significant. Results: The results suggested that the physical fatigue of the luteal phase is carried over into the menstrual phase, and the symptoms concomitant with the menstrual phase may manifest as poor mood. Furthermore, parasympathetic activity and stress coping skills tended to be higher, and sympathetic activity was lower during the menstrual phase, suggesting that students are more relaxed during the menstrual period. Conclusion: Though the results were statistically not significant, the students were in a considerably better mood during the follicular phase than the menstrual phase, suggesting that the physical and mental states may differ between the early and late follicular phases. It may be possible to evaluate the mental and physical condition of female students by obtaining more values.

Long-term wheel-running prevents reduction of grip strength in type 2 diabetic rats.

Diabetic skeletal muscles show reduced contractile force and increased fatigability. Hands are a target for several diabetes-induced complications. Therefore, reduced handgrip strength often occurs as a consequence of diabetes. The aim of this study was to examine whether long-term exercise can prevent reduction of grip strength in type 2 diabetes mellitus (T2DM) model OLETF rats, and to explore the mechanisms underlying diabetes-induced grip strength reduction. Ten 5-week-old OLETF rats were used as experimental animals, and five non-diabetic LETO rats as controls of OLETF rats. Half OLETF rats performed daily voluntary wheel-running for 17 months (OLETF + EXE), and the rest of OLETF and LETO rats were sedentary. Grip strength was higher in OLETF + EXE and LETO groups than in OLETF group. OLETF group with hyperglycemia showed an increase in HbA1c, serum TNF-α, and muscle SERCA activity, but a decrease in circulating insulin. Each fiber area, total fiber area, and % total fiber area in type IIb fibers of extensor digitorum longus muscles were larger in OLETF + EXE and LETO groups than in OLETF group. There was a positive correlation between grip strength and the above three parameters concerning type IIb fiber area. Therefore, type IIb fiber atrophy may be the major direct cause of grip strength reduction in OLETF group, although there seems multiple etiological mechanisms. Long-term wheel-running may have blocked the diabetes-induced reduction of grip strength by preventing type IIb fiber atrophy. Regular exercise may be a potent modality for preventing not only the progression of diabetes but muscle dysfunction in T2DM patients.

Parasympathetic nervous activity is associated with oxytocin in multiparous, but not primiparous, women during the perinatal period.

Oxytocin (OXT) is thought to have antidepressant/anxiolytic effects in postpartum women. Primiparous women tend toward an attenuated lactation compared with multiparous women. However, so far, little is known about the relationship between OXT and autonomic nervous activity (ANA) in perinatal women and whether it may be different in primiparous and multiparous women. Therefore, the objective of this study was to answer this question by determining both ANA and salivary OXT levels in primiparous and multiparous perinatal women. In 18 primiparous and 18 multiparous women, who underwent a physical and physiological examination, ANA measurement by heart rate variability and saliva sampling were performed during the perinatal period. Saliva OXT concentration was determined by a highly sensitive ELISA. OXT release into saliva was obtained from multiplying saliva OXT concentration by saliva flow rate. In the postpartum period, multiparous women had higher parasympathetic nervous activity (PNA) and lower physical stress index (PSI) compared with primiparous women. Furthermore, multiparous postpartal women had higher OXT compared with primiparous or multiparous prepartal women. In addition, in multiparous perinatal women, OXT correlated positively with PNA, but negatively with PSI. These results suggest that after parturition, multiparous mothers may switch over to the "feed and breed" system more quickly due to increased OXT compared with primiparous mothers. Our findings support antidepressant/anxiolytic and anti-stress effects of OXT. In postpartal women exposed to synthetic OXT, ANA measurement may provide a clue to clarify the effects of exogenous OXT on postpartum psychiatric disorders.