ABSTRACT
Cyclic voltammetry and differential pulse voltammetry were used to explore the adsorption behavior of three antibacterial agents at a carbon paste electrode. The drugs were accumulated on a carbon paste electrode, and a well-defined oxidation peak was obtained in acetate buffer (pH 5.0). The adsorptive stripping response was evaluated as a function of some variables such as the scan rate, pH and accumulation time. A simple, precise, inexpensive and sensitive voltammetric method has been developed for the determination of the cited drugs (Lomefloxacin (LFX), Sparfloxacin hydrochloride (SFX), and Gatifloxacin (GFX)). A linear calibration was obtained from 2 x 10(-7) M to 4 x 10(-5) M for LFX, 2 x 10(-7) M to 6 x 10(-5) M for SFX, and GFX. The limits of detection (LOD) were 4.2 x 10(-7), 7 x 10(-7) and 6.6 x 10(-7) M, while the limits of quantification (LOQ) were 1.4 x 10(-6), 2.3 x 10(-6) and 2.2 x 10(-6) M for LFX, SFX, and GFX, respectively. The R. S. D. of five measurements at the 1 x 10(-6) M level were 0.4, 0.5 and 0.3 for LFX, SFX and GFX, respectively. The method was applied to the determination of LFX, SFX and GFX in dilute urine samples and dosage forms, and compared with the HPLC method.
Subject(s)
Adsorption , Anti-Infective Agents/chemistry , Carbon/chemistry , Fluoroquinolones/chemistry , Chromatography, High Pressure Liquid/methods , Electrochemistry , Electrodes , Fluoroquinolones/urine , Gatifloxacin , Quinolones/chemistry , Quinolones/urineABSTRACT
This article has been retracted at the request of the Talanta Editors-in-Chief. Reason: After publication this article was discovered to have been plagiarized from an earlier work by Orlando Fatibello-Filho, Marcos Fernando de Souza Teixeira, Alexandre Zambon Pinto, presented in their paper 'Coated graphite-epoxy ion-selective electrode for the determination of iron(III) in oxalic medium', published in Analytical Letters 30 (1997) 417-427. We very much regret this error, and offer our apologies to Professor Fatibello-Filho and his co-workers. J-M. Kauffmann G.D. Christian Editors-in-Chief.
ABSTRACT
Propranolol was reacted with nitric acid to give nitropropranolol and was then measured in Britton-Robinson solutions in the pH range 2.0-12.0 by differential-pulse polarography. Nitropropranolol gave rise to a well-resolved differential-pulse polarographic peak at pH 2.0. A linear calibration graph in the range 5.0 x 10(-7)-5.0 x 10(-5) M and a detection limit of 5 nM was obtained. The relative standard deviation was 1.95% (n = 10) at 5 x 10(-6) M. The effect of common exceipient on the peak height was evaluated. The method was applied for the determination of the drug in the tablet dosage form.
