ABSTRACT
The case of a 56-year old male with an intra-abdominal metastasis from a primary lung cancer is presented. He was admitted for abdominal obstruction, toxic syndrome and paraumbilical pain. He had a previous history of squamous cell carcinoma of the right lung, for which he had undergone a right upper lobectomy in 1995, four years prior to the development of the abdominal obstruction. A debulking operation and bowel resection for the intestinal metastasis was performed. Eleven months after this operation the patient developed a recurrence: he underwent another debulking operation with resection of the sigmoid colon, jejunal segment and a small part of the bladder. The patient is alive and well 13 months after the initial operation. Intra-abdominal metastases of bronchial carcinoma may be observed with greater frequency, because of the improved survival of the patients with lung cancer. Metastatic small bowel carcinomas are rare and should be considered in the differential diagnosis of acute abdominal syndromes of patients with known history of the lung cancer. Bowel resection and debulking of the metastatic tumour mass give the best palliation and improve short-term survival.
Subject(s)
Carcinoma, Squamous Cell/pathology , Intestinal Neoplasms/secondary , Lung Neoplasms/pathology , Carcinoma, Squamous Cell/diagnostic imaging , Humans , Intestinal Neoplasms/diagnostic imaging , Intestinal Neoplasms/surgery , Male , Middle Aged , Tomography, X-Ray ComputedABSTRACT
We present a case of acute-onset diabetes insipidus in a 60-year-old woman who had been treated for breast cancer. MR images showed a thickened and enhancing pituitary stalk and an asymmetrical hypophysis. The clinical diagnosis of a pituitary metastasis of the breast carcinoma was made.
Subject(s)
Breast Neoplasms/pathology , Carcinoma, Ductal, Breast/secondary , Diabetes Insipidus/etiology , Pituitary Neoplasms/secondary , Bone Neoplasms/secondary , Fatal Outcome , Female , Humans , Liver Neoplasms/secondary , Lymphatic Metastasis , Magnetic Resonance Imaging , Middle Aged , Tomography, X-Ray ComputedABSTRACT
BACKGROUND: Postoperative 5-FU combined with levamisole increases 5 year survival in colon cancer patients (Duke C) by 30% (1). In order to investigate the potential immunological mechanism, we determined lymphocyte subtypes and markers of immune activation in 22 patients before and during one year of postoperative adjuvant treatment. METHODS: Before and regularly during treatment, according to the scheme described by Moertel (1), major lymphocyte subsets were quantified by flow cytometry. Serum neopterin, soluble IL2-receptors, beta 2-microglobulin, TNF-alpha and interferon-gamma were determined by Elisa. RESULTS: The CD4/CD8 ratio increased significantly after levamisole was added to the treatment, as did the levels of soluble IL2-receptors. The percentages of T-cells expressing the interleukin 2 receptor followed a similar trend. The levels of neopterin tended to decrease during the combined treatment course. This was paralleled by a progressive fall in the proportion of T-cells expressing HLA-DR. CONCLUSIONS: The treatment induced significant and consistent alterations in major immunological mediators and lymphocyte subtypes. It remains to be established whether these changes are related to the therapeutic effect.
Subject(s)
Adjuvants, Immunologic/administration & dosage , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Colonic Neoplasms/drug therapy , Fluorouracil/administration & dosage , Levamisole/administration & dosage , Aged , Aged, 80 and over , CD4-CD8 Ratio/drug effects , Chemotherapy, Adjuvant , Colonic Neoplasms/immunology , Female , Humans , Leukocyte Common Antigens/analysis , Male , Middle Aged , Receptors, Interleukin-2/analysis , T-Lymphocytes/drug effectsABSTRACT
Case report of a patient with a giant ovarian cyst. On the basis of literature data, surgery and histology problems, as well as oncological therapy are discussed.
Subject(s)
Cystadenocarcinoma, Mucinous/surgery , Ovarian Neoplasms/surgery , Chemotherapy, Adjuvant , Cystadenocarcinoma, Mucinous/drug therapy , Cystadenocarcinoma, Mucinous/pathology , Female , Humans , Middle Aged , Ovarian Neoplasms/drug therapy , Ovarian Neoplasms/pathologySubject(s)
Histiocytoma, Benign Fibrous/etiology , Neoplasms, Radiation-Induced/etiology , Radiotherapy, High-Energy/adverse effects , Thoracic Neoplasms/etiology , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Breast Neoplasms/radiotherapy , Female , Histiocytoma, Benign Fibrous/drug therapy , Humans , Middle Aged , Thoracic Neoplasms/drug therapyABSTRACT
Extravasation of doxorubicin (DXR) from a dorsal hand vein is described. At 28 days following this event, high dermal concentrations of DXR were still present, not only at the injection site (1.7 X 10(-6) M X g-1) but also at a distance of 5 cm (0.4 X 10(-6) m X g-1. This long persistence of DXR in the skin necessitates ample excision of the skin following severe extravasation of the drug.
Subject(s)
Doxorubicin/adverse effects , Skin Ulcer/chemically induced , Adult , Doxorubicin/administration & dosage , Doxorubicin/analysis , Female , Humans , Injections, Intravenous/adverse effects , Necrosis/chemically induced , Skin Ulcer/metabolism , Time FactorsABSTRACT
A 25-year-old man presented with a malignant teratoma of the right testicle. After orchidectomy, the results of the surgical staging procedure were negative. Although pulmonary metastasis did not occur, massive bone marrow involvement with a bleeding tendency and hypercalcemic nephropathy developed. The response to chemotherapy was excellent, but after the attainment of a complete remission the patient developed carcinomatous leptomeningitis, which was confirmed at autopsy as cause of death.
