ABSTRACT
The course of events in ischemic strokes is normally seen from a point in which the penumbra is already in place. Since there is no known treatment for edema reduction, mainstream medicine focuses on re-opening the occluded vessel. Here we show that reducing the penumbra saves neuronal units from undergoing apoptosis.
Subject(s)
Oxidants, Photochemical/therapeutic use , Ozone/therapeutic use , Stroke/drug therapy , Stroke/pathology , Adenosine Triphosphate/metabolism , Apoptosis/drug effects , Brain Edema/drug therapy , Brain Edema/etiology , Disabled Persons , Disease Progression , Glutathione Reductase/metabolism , Humans , Ischemia/complications , Lactic Acid/metabolism , Middle Cerebral Artery/drug effects , Middle Cerebral Artery/pathology , Middle Cerebral Artery/physiopathology , Neurons/drug effects , Neurons/physiology , Stroke/complications , Stroke/etiologyABSTRACT
Ozone autohemotherapy has been considered a form of alternative medicine and has not yet been subjected to the rigors of well-designed clinical trials. Despite encouraging anecdotal reports regarding the use of ozone in various disorders, there has been a concern that ozone per se may adversely affect red cell membranes and metabolites. The purpose of this study was to ascertain the effect of ozone administration at a concentration commonly used in autohemotherapy on a panel of red cell enzymes and intermediates, as well as its effect on red cell integrity. Since these parameters were unaffected by ozone, we suggest that clinical trials for the use of ozone autohemotherapy should be encouraged.
