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1.
Acta Gastroenterol Latinoam ; 45(1): 24-30, 2015 Mar.
Article in Spanish | MEDLINE | ID: mdl-26076510

ABSTRACT

INTRODUCTION: Colonoscopy is the standard method for the evaluation of the colon. A suitable intestinal cleaning is critical for the effectiveness and security of the procedure, but unfortunately there is a high proportion of suboptimal bowel preparation. OBJECTIVE: To identify factors related to suboptimal bowel preparation. METHODS: We performed an analytic, observational, cross-sectional and prospective study. We included all outpatients scheduled for colonoscopy in the Peruvian-Japanese Health Center between January and July 2012. We excluded patients with a complete or partial colonic resection. In patients with two or more colonoscopies during the study interval, only the first procedure was considered. Aronchick scale was used in assessment of bowel cleaning. The variables studied with relationship to bowel preparation were: age, sex, grade ofeducation, body mass index, time of examination, history (diabetes mellitus, stroke, cirrhosis, use of antidepressants/anxiolytics, number of bowel movements per week, abdominal surgery, personal history of previous colonoscopy, polyps and colon cancer, family history of colon cancer), received purgative, additional laxative, indication for colonoscopy and adverse effects of the preparation. Statistical analysis was made with SPSS v.160. For the categorical variables we used chi square test or Fisher exact test, whereas for continuous variables the Mann Whitney test was used. The variables significantly associated with suboptimal preparation in the univariated analysis were included in a multivariate analysis using logistic regression. RESULTS: We included 841 patients. The bowel preparation was suboptimal in 438 patients (52.1%). The univariate analysis showed that the factors related to suboptimal preparation were age (P = 0.023) and body mass index ≥ 30 kg/m2 (P = 0.021). The multivariate analysis confirmed that age ≥ 70 years old (P = 0.001) and body mass index ≥ 30 kg/m2 (P = 0.010) were the variables related to suboptimal bowel preparation. CONCLUSIONS: Age greater than 70 years old and obesity are factors related to suboptimal bowel preparation.


Subject(s)
Cathartics/administration & dosage , Colonoscopy/standards , Patient Compliance , Polyethylene Glycols/administration & dosage , Adult , Aged , Colonoscopy/methods , Colorectal Neoplasms/diagnosis , Cross-Sectional Studies , Educational Status , Female , Humans , Male , Middle Aged , Prospective Studies , Risk Factors , Therapeutic Irrigation
2.
Int J Cancer ; 123(2): 414-420, 2008 Jul 15.
Article in English | MEDLINE | ID: mdl-18449884

ABSTRACT

Most cases of gastric cancers occur in non-industrialized countries but there is scarce information about the epidemiology of this illness in these countries. Our study examined whether there was a variation in the prevalence of gastric cancer in Lima, Perú over the last 2 decades. Subjects older than 29 years of age were included. They underwent an esophagogastroduedonoscopy at 3 socioeconomically different health facilities in Lima: a county hospital (7,168 subjects), a Peruvian-Japanese Clinic (14,794 individuals) and a private hospital (4,893 individuals). Birth cohort prevalence of gastric cancer was used. Regression models were calculated to predict the future prevalence of gastric cancer. It was found that the birth cohort prevalence of gastric cancer decreased in Perú from 22.7 to 2% (p < 0.001), from 12 to 0.5% (p < 0.001), and from 6.5 to 0.1% (p < 0.001) in the low, middle and high socioeconomic group, respectively. The prevalence of intestinal metaplasia decreased from 44.3 to 12.5% (p < 0.001), from 28.4 to 5% (p < 0.001), and from 19.4 to 2.2% (p < 0.001) in the low, middle and high socioeconomic status, respectively. These trends will likely persist over the future decades. Nevertheless, the prevalence of gastric cancer remains high in subjects older than 59 years of age in the low socioeconomic status. It is concluded that the prevalence of gastric cancer is decreasing in Perú, similar to the current trend undergoing in industrialized nations. However, there are still specific groups with high prevalence that might benefit from screening for early detection and treatment.


Subject(s)
Stomach Neoplasms/epidemiology , Adult , Age Distribution , Aged , Confounding Factors, Epidemiologic , Female , Humans , Incidence , Intestines/pathology , Male , Metaplasia/epidemiology , Middle Aged , Peru/epidemiology , Poverty , Prevalence , Regression Analysis , Research Design , Retrospective Studies , Risk Factors , Sex Distribution , Social Class , Stomach Neoplasms/diagnosis , Stomach Neoplasms/etiology
3.
Acta Gastroenterol Latinoam ; 36(3): 139-46, 2006 Sep.
Article in English | MEDLINE | ID: mdl-17407990

ABSTRACT

AIM: To determine the prevalence of peptic ulcer and gastric adenocarcinoma in a population of middle and high socio-economic status in Lima, Peru, between 1985 and 2002. MATERIAL AND METHODS: The prevalence of gastroduodenal ulcer and gastric adenocarcinoma was determined after studying by esophagogastroduodenoscopy 31,446 patients at the Policlínico Peruano Japonds (PPJ) between 1985 and 2002. All patients had chronic upper gastrointestinal symptoms and had endoscopically proven diagnosis of active peptic ulcer or histological diagnosis of gastric adenocarcinoma. RESULTS: Analysis of PPJ population identified a decrease in the prevalence of gastric ulcer and duodenal ulcer from 3.15% and 5.05% respectively in 1985, to 1.62% and 2.00% respectively in 2002. Gastric adenocarcinoma prevalence also decreased from 3.19% in 1988 to 0.92% in 2002. The prevalences of gastric ulcer (OR = 1.49, 95% IC 1.26-1.77, p < 0.001), duodenal ulcer (OR = 1.32, 95% IC 1.15-1.51, p < 0.001) and gastric adenocarcinoma (OR = 1.53, 95% IC 1.25-1.86, p < 0.001), decreased in the last eight years. CONCLUSIONS: Over the study period, there was a significant decrease in the prevalence of peptic ulcer and gastric adenocarcinoma at the Policlinico Peruano Japonés, where patients from middle and high socio economic status are attended.


Subject(s)
Adenocarcinoma/epidemiology , Peptic Ulcer/epidemiology , Stomach Neoplasms/epidemiology , Adenocarcinoma/diagnosis , Adolescent , Adult , Aged , Aged, 80 and over , Cross-Sectional Studies , Duodenal Ulcer/epidemiology , Endoscopy, Digestive System , Female , Humans , Male , Middle Aged , Peptic Ulcer/diagnosis , Peru/epidemiology , Prevalence , Sex Distribution , Social Class , Stomach Neoplasms/diagnosis , Stomach Ulcer/diagnosis , Stomach Ulcer/epidemiology
4.
Acta gastroenterol. latinoam ; 36(3): 139-146, 2006. tab, graf
Article in English | LILACS | ID: lil-461600

ABSTRACT

Aim: To determine the prevalence of peptic ulcer and gastric adenocarcinoma in a population of middle and high socio-economic status in Lima, Peru, between 1985 and 2002. Materials and methods: The prevalence of gastroduodenal ulcer and gastric adenocarcinoma was determined after studying by esophagogastroduodenoscopy 31,446 patients at the Policlínico Peruano Japonés (PPJ) between 1985 and 2002. All patients had chronic upper gastrointestinal symptoms and had endoscopically proven diagnosis of active peptic ulcer or histological diagnosis of gastric adenocarcinoma. Results: Analysis of PPJ population identified a decrease in the prevalence of gastric ulcer and duodenal ulcer from 3.15% and 5.05% respectively in 1985, to 1.62% and 2.00% respectively in 2002. Gastric adenocarcinoma prevalence also decreased from 3.19% in 1988 to 0.92% in 2002. The prevalences of gastric ulcer (OR=1.49, 95% IC 1.26-1.77, p<0.001), duodenal ulcer (OR=1.32, 95% IC 1.15- 1.51, p<0.001) and gastric adenocarcinoma (OR=1.53, 95% IC 1.25-1.86, p<0.001), decreased in the last eight years. Conclusions: Over the study period, there was a significant decrease in the prevalence of peptic ulcer and gastric adenocarcinoma at the PoliclínicoPeruano Japonés, where patients from middle and high socio economic status are attended.


Objetivo: Determinar la prevalencia de la úlcera péptica y el adenocarcinoma gástrico, en una población de nivel socioeconómico medio y alto en Lima, Perú, entre los años 1985 y 2002. Material y métodos: Se determinó la prevalencia de la úlcera gastroduodenal y el adenocarcinoma gástrico, después de evaluar por esofagogastroduodenoscopía 31,446 pacientes en el Policlínico Peruano Japonés (PPJ) entre 1985 y 2002. Todos los pacientes presentaron síntomas crónicos del tracto gastrointestinal superior, y en ellos se realizó el diagnóstico endoscópico de úlcera péptica activa e histológico de adenocarcinoma gástrico. Resultados: Luego del análisis de la población estudiada se identificó una disminución de la prevalencia de úlcera gástrica y úlcera duodenal de 3,15% y 5,05% respectivamente en 1985, a 1.62% y 2.00% respectivamente en el año 2002. La prevalencia de adenocarcinoma gástrico también disminuyó de 3,19% en 1992 a 0,92% en el año 2002. Las prevalencias de ulcera gástrica (OR =1.49, 95% IC 1.26-1.77, p<0.001), úlcera duodenal (OR =1.32, 95% IC 1.15-1.51, p<0.001) y adenocarcinoma gástrico (OR =1.53, 95% IC 1.25-1.86, p<0.001), disminuyeron en los últimos 8 años cuando comparamos con los primeros años. Conclusiones: Durante este período de estudio se observó una significativa disminución de la prevalencia de la úlcera péptica y el adenocarcinoma gástrico en pacientes peruanos de nivel socio económico medio y alto que son atendidos en este nosocomio.


Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Aged, 80 and over , Adenocarcinoma/epidemiology , Peptic Ulcer/epidemiology , Stomach Neoplasms/epidemiology , Adenocarcinoma/diagnosis , Cross-Sectional Studies , Duodenal Ulcer/epidemiology , Endoscopy, Digestive System , Peptic Ulcer/diagnosis , Peru/epidemiology , Prevalence , Sex Distribution , Social Class , Stomach Neoplasms/diagnosis , Stomach Ulcer/diagnosis , Stomach Ulcer/epidemiology
5.
Acta gastroenterol. latinoam ; 36(3): 139-146, 2006. tab, graf
Article in English | BINACIS | ID: bin-123142

ABSTRACT

Aim: To determine the prevalence of peptic ulcer and gastric adenocarcinoma in a population of middle and high socio-economic status in Lima, Peru, between 1985 and 2002. Materials and methods: The prevalence of gastroduodenal ulcer and gastric adenocarcinoma was determined after studying by esophagogastroduodenoscopy 31,446 patients at the Policlínico Peruano Japonés (PPJ) between 1985 and 2002. All patients had chronic upper gastrointestinal symptoms and had endoscopically proven diagnosis of active peptic ulcer or histological diagnosis of gastric adenocarcinoma. Results: Analysis of PPJ population identified a decrease in the prevalence of gastric ulcer and duodenal ulcer from 3.15% and 5.05% respectively in 1985, to 1.62% and 2.00% respectively in 2002. Gastric adenocarcinoma prevalence also decreased from 3.19% in 1988 to 0.92% in 2002. The prevalences of gastric ulcer (OR=1.49, 95% IC 1.26-1.77, p<0.001), duodenal ulcer (OR=1.32, 95% IC 1.15- 1.51, p<0.001) and gastric adenocarcinoma (OR=1.53, 95% IC 1.25-1.86, p<0.001), decreased in the last eight years. Conclusions: Over the study period, there was a significant decrease in the prevalence of peptic ulcer and gastric adenocarcinoma at the PoliclínicoPeruano Japonés, where patients from middle and high socio economic status are attended.(AU)


Objetivo: Determinar la prevalencia de la úlcera péptica y el adenocarcinoma gástrico, en una población de nivel socioeconómico medio y alto en Lima, Perú, entre los años 1985 y 2002. Material y métodos: Se determinó la prevalencia de la úlcera gastroduodenal y el adenocarcinoma gástrico, después de evaluar por esofagogastroduodenoscopía 31,446 pacientes en el Policlínico Peruano Japonés (PPJ) entre 1985 y 2002. Todos los pacientes presentaron síntomas crónicos del tracto gastrointestinal superior, y en ellos se realizó el diagnóstico endoscópico de úlcera péptica activa e histológico de adenocarcinoma gástrico. Resultados: Luego del análisis de la población estudiada se identificó una disminución de la prevalencia de úlcera gástrica y úlcera duodenal de 3,15% y 5,05% respectivamente en 1985, a 1.62% y 2.00% respectivamente en el año 2002. La prevalencia de adenocarcinoma gástrico también disminuyó de 3,19% en 1992 a 0,92% en el año 2002. Las prevalencias de ulcera gástrica (OR =1.49, 95% IC 1.26-1.77, p<0.001), úlcera duodenal (OR =1.32, 95% IC 1.15-1.51, p<0.001) y adenocarcinoma gástrico (OR =1.53, 95% IC 1.25-1.86, p<0.001), disminuyeron en los últimos 8 años cuando comparamos con los primeros años. Conclusiones: Durante este período de estudio se observó una significativa disminución de la prevalencia de la úlcera péptica y el adenocarcinoma gástrico en pacientes peruanos de nivel socio económico medio y alto que son atendidos en este nosocomio.(AU)


Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Aged , Aged, 80 and over , Peptic Ulcer/epidemiology , Stomach Neoplasms/epidemiology , Adenocarcinoma/epidemiology , Peptic Ulcer/diagnosis , Stomach Neoplasms/diagnosis , Adenocarcinoma/diagnosis , Social Class , Peru/epidemiology , Duodenal Ulcer/epidemiology , Sex Distribution , Cross-Sectional Studies , Endoscopy, Digestive System , Stomach Ulcer/diagnosis , Stomach Ulcer/epidemiology , Prevalence
6.
Acta Gastroenterol Latinoam ; 35(4): 219-24, 2005.
Article in Spanish | MEDLINE | ID: mdl-16496853

ABSTRACT

OBJECTIVE: To compare the prevalence of Helicobacter pylori infection in native Peruvians and Japaneses residing in Peru. METHODS: Prospective study carried out at "Policlinico Peruano-Japonés" (Lima-Perú). We included Peruvians and Japaneses residing in Peru with chronic symptoms of the upper gastrointestinal tract. Both groups were from medium to high socioeconomic status. We excluded patients with peptic ulcer. PCR, rapid ureasa test and IgG ELISA were used to diagnose the infection. RESULTS: We evaluated 168 Japaneses (mean age 54.6 +/- 12.62 years, 75% female), and 161 Peruvians (mean age of 42.12 +/- 14.48 years, 61.5% female). Using the rapid ureasa test, the prevalence of Helicobacter pylori infection in Peruvians was 47.8%, and in Japaneses 47.0% (p=0.88). Using PCR, in Peruvians was 49.7% and in Japaneses 43.5% (p=0.28). CONCLUSION: Peruvians and Japaneses residing in Peru have a similar prevalence of Helicobacter pylori infection, after controlling factors such as socioeconomic status and age, suggesting that in Peru and in these ethnic groups, there is no racial predisposition to acquire the infection.


Subject(s)
Gastritis/ethnology , Helicobacter Infections/ethnology , Helicobacter pylori , Adolescent , Adult , Aged , Female , Gastritis/diagnosis , Gastritis/microbiology , Helicobacter Infections/diagnosis , Helicobacter Infections/microbiology , Humans , Japan/ethnology , Male , Middle Aged , Peru/epidemiology , Prevalence , Prospective Studies , Socioeconomic Factors
7.
Acta gastroenterol. latinoam ; 35(4): 219-24, 2005.
Article in Spanish | BINACIS | ID: bin-38191

ABSTRACT

OBJECTIVE: To compare the prevalence of Helicobacter pylori infection in native Peruvians and Japaneses residing in Peru. METHODS: Prospective study carried out at [quot ]Policlinico Peruano-Japonés[quot ] (Lima-Perú). We included Peruvians and Japaneses residing in Peru with chronic symptoms of the upper gastrointestinal tract. Both groups were from medium to high socioeconomic status. We excluded patients with peptic ulcer. PCR, rapid ureasa test and IgG ELISA were used to diagnose the infection. RESULTS: We evaluated 168 Japaneses (mean age 54.6 +/- 12.62 years, 75


female), and 161 Peruvians (mean age of 42.12 +/- 14.48 years, 61.5


female). Using the rapid ureasa test, the prevalence of Helicobacter pylori infection in Peruvians was 47.8


, and in Japaneses 47.0


(p=0.88). Using PCR, in Peruvians was 49.7


and in Japaneses 43.5


(p=0.28). CONCLUSION: Peruvians and Japaneses residing in Peru have a similar prevalence of Helicobacter pylori infection, after controlling factors such as socioeconomic status and age, suggesting that in Peru and in these ethnic groups, there is no racial predisposition to acquire the infection.

8.
Acta Gastroenterol Latinoam ; 34(2): 69-78, 2004.
Article in Spanish | MEDLINE | ID: mdl-15481796

ABSTRACT

We present the results of our investigations in the epidemiology of H. pylori infection in Peru during the last two decades. The prevalence of Helicobacter pylori infection in Lima is decreasing in people of middle and high socioeconomic status and continues stationary in people of low socioeconomic status. This decrease is similar in Peruvian and Japanese population in this city, and is associated to the decrease of the gastrointestinal diseases related to this bacterium: peptic ulcer and stomach adenocarcinoma. The infection is slightly greater in males and is acquired in early ages of life. Via oro-fecal and water contamination are probably the most important transmission ways. In our country, so far, there is no evidence to assure that some races have higher pre-disposition to acquire the infection. There are no differences in the infection by H. pylori among coast, mountain or jungle populations; and people who live in high altitudes have more atrophic chronic gastritis secondary to H. pylori infection than people who live at sea level.


Subject(s)
Helicobacter Infections/epidemiology , Helicobacter pylori , Adolescent , Adult , Age Distribution , Aged , Child , Child, Preschool , Duodenal Diseases/microbiology , Female , Helicobacter Infections/ethnology , Humans , Infant , Male , Middle Aged , Peru/epidemiology , Peru/ethnology , Prevalence , Sex Distribution
9.
Acta gastroenterol. latinoam ; 34(2): 69-78, ago. 2004. tab, graf
Article in Spanish | LILACS | ID: lil-389927

ABSTRACT

Se presentan los resultados de nuestras investigaciones en el campo de la epidemiología de la infección por el H. pylori en el Perú durante las últimas dos décadas. La prevalencia de la infección por H. pylori en Lima está disminuyendo en personas de nivel socioeconómico medio y alto, manteniéndose estacionaria en la población de nivel socioeconómico bajo. Esta disminución se está evidenciando tanto en la población peruana como en la japonesa residente en esta ciudad, y está asociada a la disminución de las enfermedades vinculadas a esta bacteria: úlcera péptica y adenocarcinoma de estómago. La infección es ligeramente más frecuente en el sexo masculino y se adquire en edades tempranas de la vida, siendo probablemente el agua y la vía oral-fecal, las formas de transmisión más importantes. Hasta el momento en nuestro país no existe evidencia que permita afirmar la mayor predisposición de ciertas razas para adquirir la infección. No hay diferencias enla infección por el H. pylori entre las poblaciones de la costa, la sierra y la selva del Perú; siendo en la población de altura más frecuente la gastritis crónica atrófica secundaria a la infección por H. pylori que en la población a nivel del mar.


Subject(s)
Humans , Male , Female , Infant , Child, Preschool , Child , Adolescent , Adult , Middle Aged , Helicobacter pylori , Helicobacter Infections/epidemiology , Age Distribution , Duodenal Diseases/microbiology , Helicobacter Infections/ethnology , Prevalence , Peru/epidemiology , Peru/ethnology , Sex Distribution
10.
Acta gastroenterol. latinoam ; 34(2): 69-78, ago. 2004. tab, graf
Article in Spanish | BINACIS | ID: bin-3399

ABSTRACT

Se presentan los resultados de nuestras investigaciones en el campo de la epidemiología de la infección por el H. pylori en el Perú durante las últimas dos décadas. La prevalencia de la infección por H. pylori en Lima está disminuyendo en personas de nivel socioeconómico medio y alto, manteniéndose estacionaria en la población de nivel socioeconómico bajo. Esta disminución se está evidenciando tanto en la población peruana como en la japonesa residente en esta ciudad, y está asociada a la disminución de las enfermedades vinculadas a esta bacteria: úlcera péptica y adenocarcinoma de estómago. La infección es ligeramente más frecuente en el sexo masculino y se adquire en edades tempranas de la vida, siendo probablemente el agua y la vía oral-fecal, las formas de transmisión más importantes. Hasta el momento en nuestro país no existe evidencia que permita afirmar la mayor predisposición de ciertas razas para adquirir la infección. No hay diferencias enla infección por el H. pylori entre las poblaciones de la costa, la sierra y la selva del Perú; siendo en la población de altura más frecuente la gastritis crónica atrófica secundaria a la infección por H. pylori que en la población a nivel del mar.(AU)


Subject(s)
Humans , Male , Female , Infant , Child, Preschool , Child , Adolescent , Adult , Middle Aged , Aged , Helicobacter pylori , Helicobacter Infections/epidemiology , Helicobacter Infections/ethnology , Duodenal Diseases/microbiology , Sex Distribution , Age Distribution , Prevalence , Peru/ethnology , Peru/epidemiology
11.
Acta gastroenterol. latinoam ; 34(2): 69-78, 2004.
Article in Spanish | BINACIS | ID: bin-38607

ABSTRACT

We present the results of our investigations in the epidemiology of H. pylori infection in Peru during the last two decades. The prevalence of Helicobacter pylori infection in Lima is decreasing in people of middle and high socioeconomic status and continues stationary in people of low socioeconomic status. This decrease is similar in Peruvian and Japanese population in this city, and is associated to the decrease of the gastrointestinal diseases related to this bacterium: peptic ulcer and stomach adenocarcinoma. The infection is slightly greater in males and is acquired in early ages of life. Via oro-fecal and water contamination are probably the most important transmission ways. In our country, so far, there is no evidence to assure that some races have higher pre-disposition to acquire the infection. There are no differences in the infection by H. pylori among coast, mountain or jungle populations; and people who live in high altitudes have more atrophic chronic gastritis secondary to H. pylori infection than people who live at sea level.

12.
Rev Gastroenterol Peru ; 23(3): 177-83, 2003.
Article in Spanish | MEDLINE | ID: mdl-14532918

ABSTRACT

AIM: The most accepted treatment for infection by Helicobacter pylori is the proton pump inhibitor based therapy with two antibiotics. However, there is no consensus regarding the duration. The purpose here was to compare eradication percentages in the omeprazole+amoxicillin+clarithromycin regimen administered during 7 days versus 10 days and confront the results with a previous 14-day* experience in Peru. METHOD: Patients from the Central Military Hospital and Peruvian-Japanese Hospital evidencing chronic upper gastrointestinal tract symptoms were recruited. We excluded patients with peptic ulcer. Biopsies were taken for diagnosis, for urease and PCR tests, culture and coloring with silver. Omeprazole+clarithromycin+amoxicillin was used during 7 days versus 10 days. Control endoscopy was performed one month after treatment had been completed and molecular biology techniques were used to differentiate recurrences from new infections. Susceptibility to clarithromycin was assessed. RESULTS: 36 patients were included in each group. Eradication was the same in both groups: 86.1% (31/36). In several patients in whom the bacteria persisted, the same initial nucleus was found. In a previous study* using this same regimen during 14 days, a 93% eradication was obtained. 91.18% of our samples were susceptible to clarithromycin. CONCLUSIONS: In Peru, the omeprazole+clarithromycin+amoxicillin combination gives results higher than 80% in the eradication of infection by Helicobacter pylori. The 7 and 10 days regimens eradicated the bacteria in 86% of our patients.


Subject(s)
Anti-Ulcer Agents/therapeutic use , Drug Therapy, Combination/therapeutic use , Helicobacter Infections/drug therapy , Helicobacter pylori/isolation & purification , Adult , Amoxicillin/therapeutic use , Clarithromycin/therapeutic use , Dose-Response Relationship, Drug , Female , Helicobacter Infections/microbiology , Humans , Male , Middle Aged , Omeprazole/therapeutic use , Time Factors , Treatment Outcome
13.
Rev. gastroenterol. Perú ; 23(3): 177-183, jul.-sept. 2003. tab
Article in Spanish | LILACS, LIPECS | ID: lil-409554

ABSTRACT

Objetivo. La terapia de un inhibidor de la bomba de protones más dos antibióticos es el tratamiento más aceptado para la infección por el helicobacter pylori. Sin embargo, no hay consenso sobre su duración. El objetivo fue comparar los porcentajes de erradicación del esquema de omeprazol+amoxicilina+claritromicina administrados durante 7 vs 10 días. Metodología: Seleccionamos pacientes del Hospital Militar Central y Policlínico Peruano-Japonés con síntomas del tracto gastrointestinal superior y Helicobacter pylori. Excluimos aquellos con úlcera péptica. Para el diagnóstico se tomaron biopsias para la prueba de la ureasa, PCR, cultivo y coloración con plata. Empleamos omeprazol+claritromicina+amoxicilina, durante 7 días versus 10 días. Realizamos endoscopía control al mes de terminado el tratamiento, y utilizamos técnicas de biología molecular para diferenciar las recurrencias de las reinfeciones. Evaluamos l susceptibilidad a claritromicina. Resultados: Incluimos 36 pacientes en cada grupo. En ambos la erradicación fue igual: 86.1 por ciento (31/36). En varios pacientes en que persistió la bacteria se identificó la misma cepa que la inicial. El 91.18 por ciento de nuestras muestras fueron sensibles a claritromicina. Conclusiones: En el Perú la combinación de omeprazol+claritromicina+amoxicilina para erradicar la infección por el Helicobacter pylori da resultados superiores al 80 por ciento. El esquema de 7 y 10 días erradicó a la bacteria en el 86 por ciento de nuestros pacientes.


Subject(s)
Humans , Omeprazole , Clinical Trials as Topic , Helicobacter pylori , Helicobacter Infections , Clarithromycin , Amoxicillin
14.
Rev. gastroenterol. Perú ; 19(3): 208-15, jul.-sept. 1999.
Article in Spanish | LILACS | ID: lil-245685

ABSTRACT

Se presenta la evaluación de 3005 casos, recogiendo nuestras observaciones sobre la epidemiología de la infección del estómago por el Helicobacter pylori en el Perú, en el curso de los últimos 15 años. Al comparar la prevalencia de la infección en japoneses inmigrantes con más de 10 años de residencia en el Perú, nisseis, visitantes japoneses al Perú con las tasas de infección de residentes peruanos, no se observó diferencia estadísticamente significativa. En la raza japonesa parecería no existir una predisposición genética para contraer la infección, siendo un factor determinante el medio ambiente al que están expuestos. En la población peruana, las tasas de infección en los diversos niveles socioeconómicos son similares, con excepción de las mujeres de nivel socio económico alto las cuales presentan una tasa de infección estadísticamente inferior. Esto último se explicaría por una menor exposición a los medios de contagio aceptados. La infección por el Helicobacter pylori es similar en las poblaciones de nivel socio económico bajo de la costa, selva y sierra del Perú. Los estudios efectaudos en niños, permiten concluir que la infección se adquiere en edades tempranas de la vida, no observándose el ascenso progresivo de la infección con la edad, descrito en países industrializados. Estudiando en Lima Metropolitana niños que beben agua proveniente de diferentes fuentes, hemos demostrado que aquellos que beben agua de la Atarjea, tienen tasas de infección superiores. Al analizar 48 muestras de diferentes fuentes de agua de Lima Metropolitana, en 24 se halló el Helicobacter pylori y de éstas 20 provenían de la Atarjea.


Subject(s)
Epidemiology , Helicobacter pylori , Case-Control Studies
15.
Rev Gastroenterol Peru ; 19(3): 208-215, 1999.
Article in Spanish | MEDLINE | ID: mdl-12207207

ABSTRACT

Compiling our observations from the last 15 years in regard to the epidemiology of Helicobacter pylori in Perú, we have analized 3005 cases. Studying and comparing the rates of infection among japanese inmigrants living in Perú for more than 10 years, niseis, japanese visitors and peruvians, we found similar rates. According to these results it seems that at least in japaneses there is not any genetic predisposition to acquire the infection. Studying peruvians of different socioeconomic levels, we observed similar rates of infection with the exception of women of high socioeconomic level. It seems that the last group of people is not exposed to the different mechanisms of infection. We found similar rates of infection in patients of low socioeconomic level living in the coast, sierra and jungle. Our studies in children showed that the infection is acquired during early childhood. Therefore in Perú we have not observed an ascending rate of infection according to age as has been described in industrialized countries. Analizing water from 48 sources we found Helicobacter pylori in 24 samples, 20 of them were taken from the municipal source of water. Water seems to be an important vehicle of infection, according to our studies, in children drinking water from different sources.

16.
Rev. gastroenterol. Perú ; 16(supl.1): S142-S147, 1996.
Article in Spanish | LILACS, LIPECS | ID: lil-504425

ABSTRACT

Se hace una revisión de la extracción de cálculos de la vía biliar utilizando procedimiento endoscópico. Se describe la técnica, indicaciones y complicaciones, haciendo énfasis en las ventajas que ofrece este método y la baja incidencia de complicaciones.


In this article, a review on bile Duch stone extraction is made using endoscopic techniques. We describe technique, indications and complications with emphasis in the adventages of this method and low incidence of complications.


Subject(s)
Bile Ducts , Gallstones , Endoscopy
17.
Bol. Soc. Peru. Med. Interna ; 4(3): 43-5, oct.-dic. 1991.
Article in Spanish | LILACS | ID: lil-123871

ABSTRACT

Presenta las características clínicas y epidemiológicas de 40 casos de cólera por vibrio cholerae 01 Ogawa observados durante la epidemia de 1991 en el Hospital Loayza de Lima. Se empleó el test de aglutinación por látex en lámina de serotipificación. Concluye, como ya ha sido reportado, que dichas características son similares al cólera producido por el serotipo Inaba


Subject(s)
Cholera/diagnosis , Vibrio cholerae
19.
Rev. gastroenterol. Perú ; 6(4): 171-177, oct.-dic. 1986. tab
Article in Spanish | LILACS, LIPECS | ID: lil-506789

ABSTRACT

El propósito de este estudio fue determinar la correlación entre el diagnóstico endoscópico e histológico de la gastritis crónica. Nosotros hemos estudiado 250 pacientes (123 varones y 127 mujeres) con edades entre los 3 a los 80 años (media = 41,5 años). Los patólogos no conocieron el diagnóstico endoscópico y los endoscopistas también ignoraron los resultados del diagnóstico histológico. La correlación del diagnóstico histológico y endoscópico fue: 70.2% para gastritis crónica superficial; 0 por ciento para atrofia parcelar de la mucosa y 18.5% para la mucosa gástrica. Nosotros concluimos que el diagnóstico endoscópico de gastritis crónica o de mucosa gástrica normal debería tener confirmación histológica. Del punto de vista endoscópico, en nuestra experiencia no es posible determinar actividad o inactividad de la gastritis crónica.


The purpose of this study was to determine the correlation between the endoscopic and histological diagnosis of chronic gastritis. We studied 250 patients (123 males and 127 females) between 3 and 80 years og age (average 41 years). The pathologist did not know the endoscopic diagnosis and endoscopists also were unaware of the result of the histological diagnosis. The correlation between the histological and endoscopic diagnosis was: 70% for chronic superficial gastritis, 0% for patchy atrophy of the epithelium atrophy of gastric epithelium. we conclude that the endoscopic diagnosis of chronic gastritis or of normal gastric epithelium should have histological confirmation. From the endoscopic view point, in our experience, it is not possible to determine activity or inactivity of chronic gastritis.


Subject(s)
Humans , Male , Female , Endoscopy , Gastritis/diagnosis , Histology
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