ABSTRACT
Circulatory shock and its treatment have been compared to a whole-body ischemia and reperfusion with activation of oxygen-derived free radicals. A pilot study had suggested a selenium redistribution in this context. To verify this hypothesis, an experimental study was designed. Temporary occlusion of the superior mesenteric artery was performed in 18 male adult Wistar rats using clamping for 0, 10, and 20 min. Hemodynamic and biochemical data were assessed before clamping and 20 min after release of the mesenteric blood flow. After release, mean arterial pressure decreased, plasma lactate increased, and erythrocyte glutathione peroxidase decreased. Plasma and erythrocyte selenium did not change; however, a slight decrease in plasma selenium was observed when related to hematocrit (to take into account the fluid balance). Erythrocyte-reduced glutathione did not change. In contrast, liver and kidney selenium increased, whereas reduced glutathione decreased in kidney, but not in liver after 20 min of clamping as compared to the sham-operated group. These results suggest that, after temporary intestinal ischemia, the changes in selenium and reduced glutathione observed in blood and tissues, like liver or kidney, could be related to a redistribution pattern in selenium metabolism during shock injury.
Subject(s)
Antioxidants/metabolism , Hemodynamics , Intestines/blood supply , Ischemia/physiopathology , Reperfusion Injury/physiopathology , Selenium/metabolism , Animals , Blood Pressure , Erythrocytes/metabolism , Free Radicals/blood , Free Radicals/metabolism , Glutathione/blood , Glutathione/metabolism , Glutathione Peroxidase/metabolism , Ischemia/blood , Ischemia/metabolism , Kidney/metabolism , Lactates/blood , Liver/metabolism , Male , Mesenteric Artery, Superior , Organ Specificity , Pilot Projects , Rats , Rats, Wistar , Reactive Oxygen Species/metabolism , Reperfusion Injury/blood , Reperfusion Injury/metabolism , Selenium/bloodSubject(s)
Intestines/blood supply , Ischemia/metabolism , Reperfusion Injury/metabolism , Selenium/metabolism , Animals , Free Radicals , Glutathione/metabolism , Male , Rats , Rats, WistarABSTRACT
The authors report a case of glomus tumour developing beneath the nail of the ring finger in a 95 year old woman. In contrast with other similar cases, the pain was moderate and had been present for 20 years. The bony phalanx was deformed. Microscopic examination confirmed the diagnosis of a glomus tumour developing in the soft tissues. The phalanx was amputated.
Subject(s)
Fingers , Glomus Tumor/diagnosis , Nails , Soft Tissue Neoplasms/diagnosis , Aged , Aged, 80 and over , Female , HumansSubject(s)
Chondrosarcoma/pathology , Hand , Soft Tissue Neoplasms/pathology , Aged , Female , Humans , PrognosisABSTRACT
Parosteal chondrosarcoma is a tumour of the soft tissues different from juxta-cortical chondrosarcoma. It is extra-periosteal, has no attachment to bone and develops primary in the soft tissues. The authors review the literature and agree that the frequency of recurrence after local excision requires treatment by amputation.