[Primary cutaneous granulomatous alternariosis]. / Primäre kutane granulomatöse Alternariose.

We report on a case of primary cutaneous granulomatous alternariosis on the forearm of a 65-year-old man who is otherwise in a good health. Histological examination revealed a predominantly histiocytic granuloma with numerous large cells containing fragments of fungi. The granuloma contained septate fungal hyphae and macroconidiospores. By means of macro- and micro-cultures the fungus was identified as an Alternaria species.

[Eccrine sweat gland nevus--immunohistochemical demonstration of MAM-3 and MAM-6 antigens]. / Ekkriner Schweissdrüsennvus--immunhistochemische Darstellung von MAM-3- und MAM-6-Antigenen.

We report the case of a 30-year-old woman suffering from multiple eccrine nevus of the sole of the foot. Using monoclonal antibodies (MoABS) against MAM antigens (human milk fat globule membrane), we achieved selective demonstration of the secretory canaliculi (MAM-6 MoABS) or the inner layer cells of eccrine duct (MAM-3 MoAbs).

[Local cutaneous amyloidoses. Report of 3 cases with lichen amyloidosus and 2 cases with nodular amyloidosis]. / Lokale kutane Amyloidosen. Bericht über drei Fälle mit Lichen amyloidosus und zwei Fälle mit nodulärer Amyloidose.

We report on the clinical and histological features of lichen amyloidosus (3 cases) as well as localized nodular amyloidosis (2 cases: a man and a woman). Regarding lichen amyloidosus, our morphological and immunohistochemical findings suggest that amyloid is derived from keratinocytes. In nodular amyloidosis, the origin of amyloid may possibly be connected with plasma cells.

[HPV-20-induced epidermodysplasia verruciformis]. / HPV-20-induzierte Epidermodysplasia verruciformis.

A 58-year-old man is presented who has suffered from epidermodysplasia verruciformis (EV) for 11 years. The lesions on the distal extremities are similar to verruca plana; those on the trunk and upper arms consist of red slightly squamous plaques. No malignant tumours have been observed so far. Only human papilloma virus (HPV), type 20, was found in all lesions. No cell mediated immune reaction disorders could be demonstrated. Virus identification is considered an important prognostic criterion.

[Disseminated neuroendocrine cancers of the skin--a cutaneous merkeliomatosis. Report of 2 cases]. / Disseminierte neuroendokrine Karzinome der Haut--eine kutane Merkeliomatose.

Two nearly identical cases with about 100 multicentric disseminated neuroendocrine carcinomas of the skin are presented. In the Merkel cell tumors a for epithelial cells specific antigen (MAM-6) was found by immunohistochemical methods. Only in one patient generalized metastases arose after a four year course of the disease. The other patient committed suicide after a three year course of the disease. At autopsy no metastases were seen. We assume these diseases to be a systemic proliferation of malignant neuroendocrine differentiated epithelial cells, for which the term "cutaneous Merkeliomatosis" is proposed.

Immunohistochemical demonstration of MAM-3 and MAM-6 antigens in normal human skin appendages and their tumors.

The expression of MAM-3 and MAM-6 antigens was immunohistochemically investigated on 110 tumors of human skin appendages. Forty-two samples from tumor-adjacent normal skin appendages were also studied. MAM-3 antigens, as detectable by monoclonal antibodies (MoAbs) 67D11, 115G3, and 115H10 were present in the inner layer cells but not in the outer layer cells of normal eccrine excretory ducts. Sporadic positivity was also found in cytoplasm of apocrine acini with 115G3, while 67D11 and 115H10 were negative. MAM-6 antigens, as detectable by the MoAbs 115D8, 115F5, 139H2, 140C1, and 126E7 were found in the secretory canaliculi of normal eccrine acini and within the apical lumina at the terminal portion of ducts. Apocrine acinar cells mainly exhibited an apical staining, but a focal supranuclear dot-like staining could also be observed. A foamy reaction pattern for MAM-6 was noted in mature sebocytes. However, none of the antigenic epitopes was expressed in normal squamous epithelium or hair follicles. In benign tumors, the staining patterns for both antigens, in general, resembled their distribution in the corresponding normal tissues. However, carcinomas originating from sweat glands, sebaceous glands, and the pilar apparatus expressed both antigens in a more irregular and heterogeneous pattern. This might preferably be explained by the loss of those mechanisms controlling the antigen expression in mature, functional tissues. Conclusions from these immunohistochemical studies with regard to the histogenesis mainly of the malignant skin appendage tumors should be drawn with caution.

[Keratosis lichenoides chronica]. / Keratosis lichenoides chronica.

We report on a case of keratosis lichenoides chronica. In our opinion, this very rare disease is an entity which might be classified as a primary inflammatory dermatosis.

[Molluscum contagiosum in a cystically dilated follicular infundibulum]. / Molluscum contagiosum in einem zystisch erweiterten Follikelinfundibulum.

We report on the hardly known development of molluscum contagiosum in a cystically dilated follicular infundibulum. The molluscum virus infection extends over two thirds of the distal cyst wall, which a rudimentary hair root ends in.