[Occupational medical aspects of COVID-19 pandemic containment: experiences from a large chemical company]. / Arbeitsmedizinische Aspekte bei der Eindämmung der COVID-19-Pandemie: Erfahrungen aus einem Großunternehmen der chemischen Industrie.

INTRODUCTION: With the present paper we aim to describe the experience of a large chemical company in tackling the COVID-19 pandemic. Specifically, we describe the timing and content of implemented measures and outline the course of the pandemic from the company's perspective. METHODS: We describe the infection protection measures and the pandemic course at the company's main site in Ludwigshafen (Germany) from March 2020 to May 2022. Company-specific data on the date of reporting an infection, suspected place of infection, number of close contacts, and the employee group were used to calculate 7-day-incidences and visualized, among other things, by means of a plant map (active infections) and a network chart (chains of infection). In addition, a weighted average of the incidences from districts close to the plant (weighted by the number of resident employees within the district) was calculated using publicly available data by the Robert Koch Institute and compared with the course of company-specific incidences. RESULTS: At the end of follow-up on 31st May 2022, 9,379 infections with SARS-CoV-2 had been recorded in employees and 758 more in leasing staff, including 368 (4%) and 84 (11%) suspected infections at the workplace/on-site, respectively. The course of 7-day incidences among employees was mainly consistent with that in the surrounding districts. The incidence of suspected infections on-site/at the workplace remained predominantly at a comparatively low level below 100 new infections over 7 days/100,000. DISCUSSION: The continuous monitoring and analysis of new SARS-CoV-2 cases among employees provides valuable information for the effective management of protective measures in the company. It enables a targeted response to changes in the number of new cases on the plant site by tightening or relaxing protective measures.

Preparedness as a key factor for human biomonitoring programs after chemical incidents.

BACKGROUND: Human biomonitoring (HBM) has been repeatedly recommended for and applied to post-incident chemical exposure assessment. The applicability of HBM and the validity of its results, however, closely depend on the existence and quality of preparatory measures such as information and instruction materials, sampling procedures, transport and storage facilities, and on the selection of appropriate biomarkers, sampling time, transport and storage conditions. OBJECTIVE: To establish a standardized HBM program for emergency responders of a large chemical production site, considering the aforementioned aspects. METHODS: An HBM program based on a comprehensive questionnaire, information and training of emergency responders, and availability of sampling material was established. The quantitative determination of metabolites of hazardous substances was carried out based on quality-controlled analytical methods. RESULTS: The use of HBM after emergency operations was significantly increased immediately after the implementation of the program. Only in single cases, however, established HBM assessment values were exceeded. After one major incident, an increased exposure to benzene exceeding the internal action value was observed after firefighting and safeguarding. SIGNIFICANCE: The experience with several minor and one major incident at a chemical production site suggests that the implementation of easily accessible and applicable routines is one paramount prerequisite for the success of HBM programs after chemical incidents.

Prevalence of back pain in employees of a German chemical company: results of a large cross-sectional study.

BACKGROUND: With the current study, we aimed to determine the prevalence of back pain in employees of a German chemical company. We put a specific focus on disabling back pain and its association with sociodemographic, lifestyle- and work-related characteristics. METHODS: We used cross-sectional data, surveyed in health check-ups between 2011 and 2014 in Ludwigshafen am Rhein (Germany). A blood sample, physical examination and anamnesis by an occupational health physician as well as a written questionnaire were part of the check-up. A modified version of the Standardised Nordic Musculoskeletal Questionnaire was utilized to survey the back-pain specific information. Disabling back pain was defined as presence of any back pain in the past 12 months which prevented employees from carrying out their usual working tasks. We used multinomial logistic regression analysis to assess the association between (categorical) duration of disabling back pain and sociodemographic, lifestyle-, and work-related characteristics. RESULTS: Overall, 17,351 employees participated in the health check-up, information on 16,792 persons could be used for analyses. Participants were on average 43.7 (SD: 9.7) years old and mainly male (79.1%). Lifetime-, 12-months-, and 7-days-prevalence of any type and duration of back pain were 72.5, 66.1, and 27.1% respectively. About one third (33.5%) had suffered from an episode of disabling back pain, 16.7% 1-7 days, 10.3% 8-30 days, and 6.5% more than 30 days. Multinomial regression analysis yielded that 8-30 days or more than 30 days of disabling back pain (relative to 0 days) were more likely with older age, female gender, being married, former or current smoking, lower occupational status, higher work-related stress score, history of a spinal injury, and diagnosed dorsopathy. CONCLUSIONS: There is a great need for action regarding multifaceted preventive measures and early interventions, especially for manual workers, older employees and women, where occupational medicine can play a decisive role.