1.
Horm Metab Res
; 9(6): 527-8, 1977 Nov.
Article
in English
| MEDLINE
| ID: mdl-590930
2.
Diabetologia
; 13(2): 153-7, 1977 Apr.
Article
in English
| MEDLINE
| ID: mdl-192620
ABSTRACT
Liver protein kinase was determined in the absence and presence of cAMP4. Experimental alloxan diabetes resulted in a decrease in total protein kinase (+cAMP) and an increase in the activity ratio (-cAMP) divided by (+cAMP) in liver. Insulin treatment of diabetic rats reversed the observed changes in protein kinase in liver. Glucagon administered in vivo to normal rats caused an increase in the activity ratio and a decrease in total protein kinase activity in liver. The changes are similar to those in diabetes. A decrease in the ratio of insulin to glucagon in diabetes may account for the changes in protein kinase observed.
Subject(s)
Cyclic AMP/metabolism , Diabetes Mellitus, Experimental/enzymology , Glucagon/pharmacology , Liver/enzymology , Protein Kinases/metabolism , Animals , Enzyme Activation , Insulin/pharmacology , Male , Rats
3.
Med Welt
; 12: 468-70, 1971 Mar 20.
Article
in German
| MEDLINE
| ID: mdl-5560084
