Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 4 de 4
Filter
Add more filters










Database
Language
Publication year range
1.
Chem Commun (Camb) ; 46(11): 1956-8, 2010 Mar 21.
Article in English | MEDLINE | ID: mdl-20198265

ABSTRACT

Novel catalytic alpha-functionalizations of non-activated aliphatic amines with silylated alkynes are reported. In the presence of the Shvo catalyst alkylations and alkynylations proceed highly selectively to the branched amines.


Subject(s)
Amines/chemistry , Ruthenium/chemistry , Alkylation , Alkynes/chemistry , Catalysis
2.
Chem Commun (Camb) ; (15): 1990-2, 2009 Apr 21.
Article in English | MEDLINE | ID: mdl-19333467

ABSTRACT

Aryl-substituted olefins react with t-butyl nitrite and sodium borohydride in the presence of iron(ii)phthalocyanine to give oximes in moderate to high yields.

3.
J Nutr ; 137(8): 1868-73, 2007 Aug.
Article in English | MEDLINE | ID: mdl-17634257

ABSTRACT

Relative bioefficacy and toxicity of Met precursor compounds were investigated in young chicks. The effectiveness of DL-Met and 2-keto-4-(methylthio)butyric acid (Keto-Met) to serve as L-Met precursors was quantified using Met-deficient diets of differing composition. Efficacy was based on slope-ratio and standard-curve methodology. Using L-Met as a standard Met source added to a purified diet, DL-Met and Keto-Met were assigned relative bioefficacy values of 98.5 and 92.5%, respectively, based on weight gain. Relative bioefficacy values of 98.5 and 89.3% were assigned to DL-Met and Keto-Met, respectively, when chicks were fed a Met-deficient, corn-soybean meal-peanut meal diet. Thus, both DL-Met and Keto-Met are effective Met precursor compounds in chicks. Additionally, growth-depressing effects of L-Met, DL-Met, and Keto-Met were compared using a nutritionally adequate corn-soybean meal diet supplemented with 15 or 30 g/kg of each compound. Similar reductions in weight gain, food intake, and gain:food ratio were observed for each compound. Subjective spleen color scores, indicative of splenic hemosiderosis, increased linearly (P < 0.01) with increasing intakes of each compound, suggesting a similarity in overall toxicity among these compounds. Because conversion of Keto-Met to L-Met in vivo merely requires transamination, Keto-Met may prove to be a useful supplement not only in food animal production, but also as a component of enteral and parenteral formulas for humans suffering from renal insufficiency.


Subject(s)
Chickens/metabolism , Methionine/analogs & derivatives , Methionine/metabolism , Animal Feed , Animal Nutritional Physiological Phenomena , Animals , Diet/veterinary , Dose-Response Relationship, Drug , Methionine/pharmacology
4.
Bioorg Med Chem ; 13(19): 5680-5, 2005 Oct 01.
Article in English | MEDLINE | ID: mdl-15964195

ABSTRACT

The potential of novel and known pyridyl thiourea derivatives (non-nucleoside inhibitors (NNI) of HIV reverse transcriptase) as bifunctional organic catalysts in the asymmetric Strecker synthesis was investigated. It was shown that incorporation of the imidazolyl moiety in place of a pyridyl group results in a new thiourea derivative that displays a much higher catalytic activity.


Subject(s)
HIV Reverse Transcriptase/antagonists & inhibitors , HIV/enzymology , Reverse Transcriptase Inhibitors/chemical synthesis , Thiourea/chemical synthesis , Catalysis , Crystallography, X-Ray , Models, Molecular , Molecular Structure , Reverse Transcriptase Inhibitors/chemistry , Reverse Transcriptase Inhibitors/pharmacology , Stereoisomerism , Structure-Activity Relationship , Thiourea/chemistry , Thiourea/pharmacology
SELECTION OF CITATIONS
SEARCH DETAIL
...