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1.
Clin Nutr ; 33(5): 793-801, 2014 Oct.
Article in English | MEDLINE | ID: mdl-24342258

ABSTRACT

BACKGROUND & AIMS: A quantitative systematic identification and prioritization of unmet needs and research opportunities in relation to enteral nutrition was conducted by means of a tailor-made health research prioritization process. METHODS: The research objectives were reached by conducting qualitative interviews followed by quantitative questionnaires targeting enteral nutrition key opinion leaders (KOLs). (1) Define disease areas that deserve more research attention; (2) Rank importance of product characteristics of tube feeding (TF) and oral nutritional supplements (ONS); (3) Assess involvement of KOLs in enteral nutrition R&D process. KOLs ranked three product characteristics and three disease areas that deserve additional research attention. From these, overall priority scores were calculated by multiplying ranks for both product characteristics and disease areas. RESULTS: 17 qualitative interviews were conducted and 77 questionnaires (response rate 35%) were completed and returned. (1) Disease areas in ONS and TF with highest priorities are: ONS: general malnutrition & geriatrics, TF: intensive care. (2) TF product characteristics with highest priorities are: composition and clinical evidence from a KOL perspective; tolerance and ease of use from a patient perspective. ONS product characteristics with highest priorities are: composition, clinical evidence and taste from a KOL perspective; taste from a patient perspective. We find a high discrepancy between product characteristic prioritization from a KOL and patient perspective. (3) Although 62% of all KOLs give advice to enteral nutrition companies on patient needs, they under-influence the setting of research priorities by enteral nutrition companies. CONCLUSIONS: This study provides a systematic approach to achieve research prioritization in enteral nutrition. In addition to providing new directions for enteral nutrition research and development, this study highlights the relevance of involving KOLs in the identification of research priorities as they have the ability to provide a balanced view of the unmet patient needs.


Subject(s)
Enteral Nutrition/methods , Health Services Needs and Demand , Research , Adult , Critical Care , Geriatrics/methods , Humans , Malnutrition/diagnosis , Middle Aged , Surveys and Questionnaires , Young Adult
2.
Benef Microbes ; 5(1): 19-28, 2014 Mar.
Article in English | MEDLINE | ID: mdl-23886977

ABSTRACT

Recent studies suggested that manipulation of the composition of the microbial ecosystem in the gut might be a novel approach in the treatment of obesity. Such treatment might consist of altering the composition of the microbial communities of an obese individual by administration of beneficial microorganisms, commonly known as probiotics. Here, we intend to contribute to the developmental process of probiotic treatment of human obesity. The aim is to review the evidence regarding the potential effect of probiotic strains on reduction of weight and body fat. A literature study was conducted focusing on clinical trials that examined the effect of specific microorganisms on body weight control. Analysis of the eligible articles pointed out that Lactobacillus gasseri SBT 2055, Lactobacillus rhamnosus ATCC 53103, and the combination of L. rhamnosus ATCC 53102 and Bifidobacterium lactis Bb12 may reduce adiposity, body weight, and weight gain. This suggests that these microbial strains can be applied in the treatment of obesity. Furthermore, short chain fatty acid production and low grade inflammation were found as the underlying mechanisms of action that influence metabolism and affect body weight. These findings might contribute to the development of probiotic treatment of obesity. Further research should be directed to the most effective combination and dosage rate of probiotic microorganisms.


Subject(s)
Fatty Acids, Volatile/biosynthesis , Gastrointestinal Tract/microbiology , Inflammation/microbiology , Obesity/therapy , Probiotics/therapeutic use , Adipose Tissue/microbiology , Adiposity , Bifidobacterium/metabolism , Body Weight , Humans , Inflammation/immunology , Lactobacillus/metabolism , Microbiota , Weight Loss
3.
Vaccine ; 29(35): 5846-9, 2011 Aug 11.
Article in English | MEDLINE | ID: mdl-21722688

ABSTRACT

Gold dimensions of pharmaceutical drug development indicate that it takes on average 11.9 years, with an investment around US$ 0.8 Billion, to launch one product on the market. Furthermore, approximately 22% of the drug candidates successfully complete clinical testing. These universally acknowledged proportions largely originate from one single, much cited publication; Dimasi et al. [5]. However an additional six articles describing new chemical entities (NCE) development were identified, which contain little, if any, information on vaccines. Published cumulative success rates range from 7% to 78% and investments calculations span US$ 0.8 to 1.7 Billion. Obviously this disserves further clarification?


Subject(s)
Drug Industry/economics , Pharmaceutical Preparations/economics , Vaccines/economics , Biomedical Research , Drug Industry/statistics & numerical data , Humans , Investments/economics , Risk
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