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Bioorg Med Chem Lett
; 13(6): 1015-8, 2003 Mar 24.
Article
in English
| MEDLINE
| ID: mdl-12643901
ABSTRACT
The association of ICAM-1 with LFA-1 plays a critical role in several autoimmune diseases. N-2-Bromobenzoyl L-tryptophan, compound 1, was identified as an inhibitor to the formation of the LFA-1/ICAM complex. The SAR of the amino acid indicates that the carboxylic acid is required for inhibition and that L-histidine is the most favored amino acid.