ABSTRACT
The resistance-inducing capacity of ciprofloxacin is still controversial. In order to assess the changes in susceptibility behavior, ciprofloxacin was given as antibiotic cover for transurethral maneuvers in multiple sclerosis (MS) patients with urinary tract infection prone to recurrence after treatment. The aim was to compare the susceptibility pattern before and after treatment in a double-blind study using two different dose regimens. Sixty-one patients were randomly separated in two groups who received 100 and 500 mg ciprofloxacin orally, twice a day for 4 days. Bacterial cultures were performed before and at the fourth day of treatment as well as at 6 days and 4 weeks after the end of treatment. Altered susceptibility behavior, defined as an elevation of the primary minimum inhibitory concentration by at least two dilution steps, was only found in three causative organisms out of 86, demonstrating the low resistance-inducing capacity of ciprofloxacin. There was no significant dosage-related difference.
Subject(s)
Bacteriuria/prevention & control , Ciprofloxacin/therapeutic use , Premedication , Urinary Bladder, Neurogenic/microbiology , Bacteriuria/microbiology , Ciprofloxacin/administration & dosage , Cystoscopy , Double-Blind Method , Female , Humans , Male , Microbial Sensitivity Tests , Middle Aged , Multiple Sclerosis/complications , Urinary Bladder, Neurogenic/etiologySubject(s)
Ciprofloxacin/therapeutic use , Urinary Bladder, Neurogenic/microbiology , Urinary Tract Infections/drug therapy , Adult , Aged , Anti-Bacterial Agents/therapeutic use , Controlled Clinical Trials as Topic , Female , Humans , Male , Microbial Sensitivity Tests , Middle Aged , Urinary Bladder, Neurogenic/drug therapySubject(s)
Anti-Infective Agents/therapeutic use , Enterobacteriaceae Infections/drug therapy , Multiple Sclerosis/complications , Pseudomonas Infections/drug therapy , Quinolines/therapeutic use , Urinary Tract Infections/drug therapy , Catheters, Indwelling , Ciprofloxacin , Cystitis/drug therapy , Enterobacteriaceae Infections/complications , Female , Humans , Male , Pseudomonas Infections/complications , Pyelonephritis/drug therapy , Urinary Tract Infections/complications , Urinary Tract Infections/microbiologyABSTRACT
In an open study, a group of 11 patients with asymptomatic urinary tract infections, caused by resistant Pseudomonas strains, were given 200 mg of ciprofloxacin per day for 1 week. All strains displayed an in vitro sensitivity to the drug. Complete clinical resolution was obtained in 8 patients and long-term eradication in 3. No adverse reactions and only minor and reversible laboratory changes were recorded. Ciprofloxacin could be a valuable oral drug in the treatment of severe urinary infections. However, more clinical studies on the development of resistance under therapy and with other dose schedules are indicated.
