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2.
Br J Dermatol ; 182(6): 1343-1344, 2020 06.
Article in English | MEDLINE | ID: mdl-31529471

ABSTRACT

AIM: Jansen et al. conducted a randomized trial to compare the efficacy of four field treatments for actinic keratosis (AK). SETTING AND DESIGN: This was a multicentre, single-blind, randomized trial conducted in the dermatology departments of four Netherlands hospitals. Patients were not blinded. The investigator who evaluated the trial outcome was blinded. STUDY EXPOSURE: This study included adult patients with at least five AKs on the face or vertex scalp. Patients were randomized to treatment with fluorouracil 5% cream, imiquimod 5% cream, methyl aminolaevulinate photodynamic therapy (MAL-PDT) or ingenol mebutate 0·015% gel. OUTCOMES: The primary outcome was whether patients had ≥ 75% reduction in AK count 12 months after treatment. RESULTS: In total 624 patients participated. The likelihood of having ≥ 75% reduction in AK count 12 months after treatment was significantly higher (twice as high or greater) for fluorouracil than for any other therapy. Approximately 75% of patients treated with fluorouracil experienced ≥ 75% reduction in AK count at 12 months. CONCLUSIONS: Jansen et al. conclude that 1 year after treatment, fluorouracil was significantly more effective at AK reduction than imiquimod, MAL-PDT or ingenol mebutate.


Subject(s)
Keratosis, Actinic , Photochemotherapy , Adult , Aminolevulinic Acid , Humans , Netherlands , Photosensitizing Agents , Single-Blind Method
3.
Br J Dermatol ; 182(4): 824, 2020 04.
Article in English | MEDLINE | ID: mdl-31849050
4.
6.
Br J Dermatol ; 180(4): 693-694, 2019 04.
Article in English | MEDLINE | ID: mdl-30933347

Subject(s)
Dermatology
8.
Br J Dermatol ; 178(1): 15-16, 2018 01.
Article in English | MEDLINE | ID: mdl-29357579
9.
Opt Express ; 14(11): 4928-34, 2006 May 29.
Article in English | MEDLINE | ID: mdl-19516652

ABSTRACT

The conversion of light fields in photonic crystal fibers (PCFs) capitalizes on the dramatic enhancement of several optical nonlinearities. We present here spectrally smooth, highly broadband supercontinuum radiation in a short piece of high-nonlinearity soft-glass PCF. This supercontinuum spans several optical octaves, with a spectral range extending from 350 nm to beyond 3000 nm. The selection of an appropriate propagation-length determines the spectral quality of the supercontinuum generated. Experimentally, we clearly identify two regimes of nonlinear pulse transformation: when the fiber length is much shorter than the dispersion length, soliton propagation is not important and a symmetric supercontinuum spectrum arises from almost pure self-phase modulation. For longer fiber lengths the supercontinuum is formed by the breakup of multiple Raman-shifting solitons. In both regions very broad supercontinuum radiation is produced.

10.
Appl Microbiol Biotechnol ; 66(1): 71-3, 2004 Nov.
Article in English | MEDLINE | ID: mdl-15455180

ABSTRACT

The 3D structures of Fim H and PapG proteins complexed with the host carbohydrate receptor demonstrate that both utilize binding-pocket asparagines for contact or stabilization with the carbohydrate. Pretreatment of whole bacteria with asparaginase resulted in decreased fimbriae-mediated attachment to urinary epithelial cells. Enzyme treatment of bacteria pre-adhered to epithelial cells removed more uropathogenic E. coli than the indigenous flora attached to them.


Subject(s)
Asparaginase/pharmacology , Bacterial Adhesion/drug effects , Escherichia coli/drug effects , Fimbriae, Bacterial/drug effects , Urinary Tract/microbiology , Bacterial Adhesion/physiology , Epithelial Cells/microbiology , Escherichia coli/physiology , Fimbriae Proteins/chemistry , Fimbriae Proteins/drug effects , Humans , Urinary Tract/cytology
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