Decoding chronic rhinosinusitis: A metabolomics-based approach.

BACKGROUND: Chronic rhinosinusitis (CRS) is a common and intractable disease in otorhinolaryngology, laying a heavy burden on healthcare systems. The worldwide researchers are making efforts to find solutions to this disease. Metabolomics has recently gained more and more traction, and might become a promising tool to unravel the complexity of CRS. This paper provides an overview of current studies on the metabolomics of various CRS subtypes. METHODS: We conducted a comprehensive literature search in PubMed, Web of Science, EMBASE, Google Scholar, and Cochrane Library, up to May 25, 2023. Search strategies incorporated key terms such as "chronic rhinosinusitis" and "metabolomics" with relevant synonyms and MeSH terms. Titles and abstracts of 86 screened articles were assessed for relevance to CRS and metabolomics. Methodological robustness, data reliability, and relevance were considered for shortlisted articles. RESULTS: After the refined process, a total of 26 articles were included in this study and sorted out by research themes, methodology and pivotal discoveries. These included studies identified the metabolic pathways and markers related to the pathophysiology in each subtype of CRS. CONCLUSIONS: Metabolomics helps to shed light on the complexity of CRS. The mentioned findings highlight the importance of specific metabolic pathways and markers in understanding the pathophysiology of CRS. Despite that, challenges and future directions in metabolomics research for CRS would be worth being further explored.

Coaxial Triboelectric Nanogenerator and Supercapacitor Fiber-Based Self-Charging Power Fabric.

Although there has been rapid advancement in wearable electronics, challenges still remain in developing wearable and sustainable power sources with simple fabrication and low cost. In this work, we demonstrate a flexible coaxial fiber by fabricating a one-dimensional triboelectric nanogenerator (TENG) outside and a supercapacitor (SC) inside, which can not only harvest mechanical energy but also store energy in the all-in-one fiber. In such a coaxial fiber, carbon fiber bundles are utilized as the electrode material for the TENG as well as the active and electrode material for the SC. Meanwhile, silicone rubber serves as the separator between the SC and TENG, as the triboelectric material for the TENG, and as the encapsulation material for the whole fiber as well. Moreover, both SC and TENG exhibit good performance and stability, which ensures their long-term use in daily life. Because of the flexibility and durability of the carbon fiber and silicone rubber, the proposed coaxial fibers show great flexibility, which could be further knitted as cloth for sustainably powering wearable electronic devices. This work presents a promising platform for wearable electronics as well as smart textiles.