Therapeutic drug monitoring of perospirone: The lowest effective plasma concentration in patients with schizophrenia.

OBJECTIVES: This study investigated the effects of demographic factors such as age, sex and comedications on the plasma concentrations of perospirone in individuals diagnosed with schizophrenia. Additionally, the relationship between these plasma levels and the clinical efficacy of the medication was explored. METHODS: Data regarding the plasma concentration of perospirone in patients with schizophrenia were obtained from the Xi'an Mental Health Center and were retrospectively analysed. RESULTS: The study results revealed a range of 0.50-1.59 ng/mL for the 25th-75th percentile of perospirone concentration in the plasma, which ranged from 0.07 to 6.0 ng/mL. The plasma concentration of perospirone increased with the daily oral dose (r = 0.283, P < 0.05). Furthermore, patients with higher plasma perospirone concentrations and concentration-to-dose ratios (C/D) tended to be older or were women. Notably, the coadministration of valproate significantly reduced perospirone concentration and the C/D ratio by 54.7% and 35.3%, respectively (P < 0.01). Receiver operating characteristics curve analyses revealed that patients exhibited a good clinical response when their plasma perospirone concentrations were ≥ 1.17 ng/mL. CONCLUSION: The findings suggest that therapeutic drug monitoring of perospirone and adjustments to achieve steady-state concentrations of ≥ 1.17 ng/mL can be beneficial for optimising treatment for patients with schizophrenia.

Exploring moderators of mirror exposure on pre- to post changes in body image outcomes: Systematic review and meta-analysis.

PURPOSE: Mirror exposure (ME) is embedded within cognitive behavioral treatment of body image concern (BIC), and existing literature demonstrates its potential value as a BIC intervention. The purpose of the study is to provide a meta-analytic review of ME effects on attitudinal and behavioral BIC. METHODS: Twelve studies met inclusion criteria, yielding six between-group and 18 within-group comparisons. RESULTS: Random effects models demonstrated a medium effect of ME versus control conditions, on attitudinal BIC, from pre- to immediate posttreatment, small effect at follow-up (1 to 4 weeks posttreatment), and large effect on behavioral BIC pre- to immediate posttreatment. However, small sample sizes yielded nonsignificant findings and significant heterogeneity. Exploratory moderator analyses-ME type, ME dosage (session frequency, duration), and diagnosis-demonstrated that, among single group pre-post designs, higher ME dosage may be instrumental to pre-posttreatment improvements. Consistent with this finding, individual studies with high dosages of ME demonstrated the largest effect sizes. Conclusion: Results may suggest a strong ME effect on BIC at high dosages (>120 minutes). The current review highlights gaps in ME literature and the need for future clinical trials assessing ME, using a priori, high-quality research designs that further the understanding of ME's mechanisms of change.

Chemical- and Mechanical-Induced Lubrication Mechanisms during Hot Rolling of Titanium Alloys Using a Mixed Graphene-Incorporating Lubricant.

Hot rolling of titanium alloy currently is carried out without lubrication because of the surface defects. In order to explore an effective lubrication scheme to reduce friction and wear during hot rolling of titanium alloy, a mixed graphene-incorporating lubricant has been proposed to study its lubrication performance and mechanism. The tribological experiments were carried out by ball-disk friction and wear tester under hot-rolling parameters. Scanning electron microscopy (SEM), X-ray energy spectrum analyzer (EDS), X-ray powder diffractometer (XRD) and Raman analysis were used to analyse the surface and cross-section of the wear marks on the samples after the tribological experiments. The results show that the friction coefficient decreases up to about 35% compared with tests under dry and lubricated conditions. The surface quality of the wear marks is improved significantly after applying the proposed lubricant. The graphene which is embedded in the phosphate film can be effectively applied as a lubricating material to strengthen the lubricating film with less combustion loss at high temperatures. A chemical- and mechanical-induced lubrication mechanism for the hot rolling of titanium sheets has been proposed due to the synergistic lubrication effect of the graphene, ZrO2 nano particles and phosphate. It is of great significance and potential value to apply this proposed lubricant as an effective way to reduce the wear, friction and oxidation during the hot-rolling process of titanium alloy.

Effect of Compressive Prestrain on the Anti-Pressure and Anti-Wear Performance of Monolayer MoS2: A Molecular Dynamics Study.

The effects of in-plane prestrain on the anti-pressure and anti-wear performance of monolayer MoS2 have been investigated by molecular dynamics simulation. The results show that monolayer MoS2 observably improves the load bearing capacity of Pt substrate. The friction reduction effect depends on the deformation degree of monolayer MoS2. The anti-pressure performance of monolayer MoS2 and Pt substrate is enhanced by around 55.02% when compressive prestrain increases by 4.03% and the anti-wear performance is notably improved as well. The improved capacities for resisting the in-plane tensile and out-of-plane compressive deformation are responsible for the outstanding lubrication mechanism of monolayer MoS2. This study provides guidelines for optimizing the anti-pressure and anti-wear performance of MoS2 and other two-dimension materials which are subjected to the in-plane prestrain.

A study on the tribological property of MoS2/Ti-MoS2/Si multilayer nanocomposite coating deposited by magnetron sputtering.

Pure MoS2 coatings are easily affected by oxygen and water vapor to form MoO3 and H2SO4 which cause a higher friction coefficient and shorter service life. In this work, five kinds of MoS2/Ti-MoS2/Si multilayer nanocomposite coatings have been deposited by using unbalanced magnetron sputtering with different modulation period ratios. The tribological tests and nano-indentation experiments have been carried out in order to study the tribological and mechanical properties of the multilayer nanocomposite coating. The results show that the hardness and internal stress of the multilayer nanocomposite coatings are superior to those of the pure MoS2 coating. The polycrystalline columnar structures are effectively inhibited and the coating densification increases due to the multilayer nanostructure and the doped elements of Ti and Si. The nanocomposite coating with a modulation period ratio of 100 : 100 shows the lowest friction coefficient and wear rate. The multilayer nanocomposite coatings exhibit excellent tribological property under a heavy constant load. Interfaces in multilayer nanostructure coating is able to hinder the dislocations motion and the crack propagation. The doped elements of Ti and Si with nano-multilayer structure enhances the mechanical and tribological properties of MoS2 coating. This study provides guidelines for optimizing the mechanical and tribological properties of MoS2 coating.