Macrophage fatty acid oxidation in atherosclerosis.

Atherosclerosis significantly contributes to the development of cardiovascular diseases (CVD) and is characterized by lipid retention and inflammation within the artery wall. Multiple immune cell types are implicated in the pathogenesis of atherosclerosis, macrophages play a central role as the primary source of inflammatory effectors in this pathogenic process. The metabolic influences of lipids on macrophage function and fatty acid ß-oxidation (FAO) have similarly drawn attention due to its relevance as an immunometabolic hub. This review discusses recent findings regarding the impact of mitochondrial-dependent FAO in the phenotype and function of macrophages, as well as transcriptional regulation of FAO within macrophages. Finally, the therapeutic strategy of macrophage FAO in atherosclerosis is highlighted.

Efficacy and safety of coronary stent intervention for coronary heart disease and its impact on short-term and long-term prognosis.

OBJECTIVE: To investigate the effect of coronary stent intervention on the efficacy, safety, and short-term and long-term prognosis of patients with coronary heart disease (CHD). METHODS: From March 2016 to November 2017, 60 cases of CHD patients receiving coronary stent interventiontherapy (research group) and 42 cases of patients receiving conventional drug therapy (control group) in our hospital were recruited as research objects. The clinical efficacy, safety and prognosis in the two groups were compared, and the levels of matrix metalloproteinase-9 (MMP-9) and interleukin-33 (IL-33) in the two groups were measured before and after treatment. RESULTS: The clinical efficacy and prognostic quality of life of patients in the research group were higher than those in the control group (P<0.050), and the serum levels of MMP-9 and IL-33 in the research group were higher than those in the control group after treatment (P<0.050). CONCLUSION: Compared with drug therapy alone, coronary stent intervention therapy has better clinical efficacy and short-term and long-term prognosis in treating CHD, but it is easy to promote inflammatory reaction after surgery. Therefore, attention should be paid to the control of inflammation before and after treatment.