HervD Atlas: a curated knowledgebase of associations between human endogenous retroviruses and diseases.

Human endogenous retroviruses (HERVs), as remnants of ancient exogenous retrovirus infected and integrated into germ cells, comprise ∼8% of the human genome. These HERVs have been implicated in numerous diseases, and extensive research has been conducted to uncover their specific roles. Despite these efforts, a comprehensive source of HERV-disease association still needs to be added. To address this gap, we introduce the HervD Atlas (https://ngdc.cncb.ac.cn/hervd/), an integrated knowledgebase of HERV-disease associations manually curated from all related published literature. In the current version, HervD Atlas collects 60 726 HERV-disease associations from 254 publications (out of 4692 screened literature), covering 21 790 HERVs (21 049 HERV-Terms and 741 HERV-Elements) belonging to six types, 149 diseases and 610 related/affected genes. Notably, an interactive knowledge graph that systematically integrates all the HERV-disease associations and corresponding affected genes into a comprehensive network provides a powerful tool to uncover and deduce the complex interplay between HERVs and diseases. The HervD Atlas also features a user-friendly web interface that allows efficient browsing, searching, and downloading of all association information, research metadata, and annotation information. Overall, the HervD Atlas is an essential resource for comprehensive, up-to-date knowledge on HERV-disease research, potentially facilitating the development of novel HERV-associated diagnostic and therapeutic strategies.

Historical record of nutrients inputs into the Xin'an Reservoir and its potential environmental implication.

The Xin'an Reservoir is an important water supply source and water conservation area for the Qiantang River. However, after the occurrence of the two algae blooms in 1998 and 1999, the safety of water quality has been put into question. In order to study the historical deposition of nutrients, sediment cores were collected in different regions from the Xin'an Reservoir. The stable isotopes δ13C and δ15N, nutrients, total organic carbon (TOC), and inorganic carbon (IC) in the sediment cores were determined. Radiometric methods (210Pb and 137Cs) were used to obtain sediment chronologies. Spatially, it was found that the average total nitrogen (TN) content in the upper 5 cm of sediments increased from 0.21% in the riverine zone, to 0.33%, and then to 0.57% in the lacustrine zone. The average TP content in the upper 5 cm increased from 0.67 g kg-1 in the riverine zone, to 1.03 g kg-1 in the estuary region, and then to 1.65 g kg-1 in the lacustrine zone. In addition, TOC levels showed a distinct increase from 1.42% in the bottom to 5.97% in the surface of the lacustrine zone. These results demonstrated that although primary productivity and the input of nutrients constantly increased in recent years, algae blooms rarely occurred in the Xin'an Reservoir, due to "depth effect" and an aquatic environment protection-oriented fishery policy. However, high TOC flux and high bio-available phosphorus and nitrogen in surface sediment demonstrated that the reservoir is still confronted with the potential risk of algae blooms.