SimpleTrack: Rethinking and Improving the JDE Approach for Multi-Object Tracking.

Joint detection and embedding (JDE) methods usually fuse the target motion information and appearance information as the data association matrix, which could fail when the target is briefly lost or blocked in multi-object tracking (MOT). In this paper, we aim to solve this problem by proposing a novel association matrix, the Embedding and GioU (EG) matrix, which combines the embedding cosine distance and GioU distance of objects. To improve the performance of data association, we develop a simple, effective, bottom-up fusion tracker for re-identity features, named SimpleTrack, and propose a new tracking strategy which can mitigate the loss of detection targets. To show the effectiveness of the proposed method, experiments are carried out using five different state-of-the-art JDE-based methods. The results show that by simply replacing the original association matrix with our EG matrix, we can achieve significant improvements in IDF1, HOTA and IDsw metrics, and increase the tracking speed of these methods by around 20%. In addition, our SimpleTrack has the best data association capability among the JDE-based methods, e.g., 61.6 HOTA and 76.3 IDF1, on the test set of MOT17 with 23 FPS running speed on a single GTX2080Ti GPU.

Hierarchically Hybrid Porous Co3O4@NiMoO4/CoMoO4 Heterostructures for High-Performance Electrochemical Energy Storage.

Hierarchical, ultrathin, and porous NiMoO4@CoMoO4 on Co3O4 hollow bones were successfully designed and synthesized by a hydrothermal route from the Co-precursor, followed by a KOH (potassium hydroxide) activation process. The hydrothermally synthesized Co3O4 nanowires act as the scaffold for anchoring the NiMoO4@CoMoO4 units but also show more compatibility with NiMoO4, leading to high conductivity in the heterojunction. The intriguing morphological features endow the hierarchical Co3O4@NiMoO4@CoMoO4 better electrochemical performance where the capacity of the Co3O4@NiMoO4@CoMoO4 heterojunction being 272 mA·h·g-1 at 1 A·g-1 can be achieved with a superior retention of 84.5% over 1000 cycles. The enhanced utilization of single/few NiMoO4@CoMoO4 shell layers on the Co3O4 core make it easy to accept extra electrons, enhancing the adsorption of OH- at the shell surface, which contribute to the high capacity. In our work, an asymmetric supercapacitor utilizing the optimized Co3O4@NiMoO4@CoMoO4 activated carbon (AC) as electrode materials was assembled, namely, Co3O4@NiMoO4@CoMoO4//AC device, yielding a maximum high energy density of 53.9 W·h·kg-1 at 1000 W·kg-1. It can retain 25.92 W·h·kg-1 even at 8100 W·kg-1, revealing its potential and viability for applications. The good power densities are ascribed to the porous feature from the robust architecture with recreated abundant mesopores on the composite, which assure improved conductivity and enhanced diffusion of OH- and also the electron transport. The work demonstrated here holds great promise for synthesizing other heterojunction materials M3O4@MMoO4@MMoO4 (M = Fe, Ni, Sn, etc).

Brain functional and effective connectivity based on electroencephalography recordings: A review.

Functional connectivity and effective connectivity of the human brain, representing statistical dependence and directed information flow between cortical regions, significantly contribute to the study of the intrinsic brain network and its functional mechanism. Many recent studies on electroencephalography (EEG) have been focusing on modeling and estimating brain connectivity due to increasing evidence that it can help better understand various brain neurological conditions. However, there is a lack of a comprehensive updated review on studies of EEG-based brain connectivity, particularly on visualization options and associated machine learning applications, aiming to translate those techniques into useful clinical tools. This article reviews EEG-based functional and effective connectivity studies undertaken over the last few years, in terms of estimation, visualization, and applications associated with machine learning classifiers. Methods are explored and discussed from various dimensions, such as either linear or nonlinear, parametric or nonparametric, time-based, and frequency-based or time-frequency-based. Then it is followed by a novel review of brain connectivity visualization methods, grouped by Heat Map, data statistics, and Head Map, aiming to explore the variation of connectivity across different brain regions. Finally, the current challenges of related research and a roadmap for future related research are presented.

Incorporating clinical parameters to improve the accuracy of angiography-derived computed fractional flow reserve.

Aims: Angiography-derived fractional flow reserve (angio-FFR) permits physiological lesion assessment without the need for an invasive pressure wire or induction of hyperaemia. However, accuracy is limited by assumptions made when defining the distal boundary, namely coronary microvascular resistance (CMVR). We sought to determine whether machine learning (ML) techniques could provide a patient-specific estimate of CMVR and therefore improve the accuracy of angio-FFR. Methods and results: Patients with chronic coronary syndromes underwent coronary angiography with FFR assessment. Vessel-specific CMVR was computed using a three-dimensional computational fluid dynamics simulation with invasively measured proximal and distal pressures applied as boundary conditions. Predictive models were created using non-linear autoregressive moving average with exogenous input (NARMAX) modelling with computed CMVR as the dependent variable. Angio-FFR (VIRTUheart™) was computed using previously described methods. Three simulations were run: using a generic CMVR value (Model A); using ML-predicted CMVR based upon simple clinical data (Model B); and using ML-predicted CMVR also incorporating echocardiographic data (Model C). The diagnostic (FFR ≤ or >0.80) and absolute accuracies of these models were compared. Eighty-four patients underwent coronary angiography with FFR assessment in 157 vessels. The mean measured FFR was 0.79 (±0.15). The diagnostic and absolute accuracies of each personalized model were: (A) 73% and ±0.10; (B) 81% and ±0.07; and (C) 89% and ±0.05, P < 0.001. Conclusion: The accuracy of angio-FFR was dependent in part upon CMVR estimation. Personalization of CMVR from standard clinical data resulted in a significant reduction in angio-FFR error.

FSD-BRIEF: A Distorted BRIEF Descriptor for Fisheye Image Based on Spherical Perspective Model.

Fisheye images with a far larger Field of View (FOV) have severe radial distortion, with the result that the associated image feature matching process cannot achieve the best performance if the traditional feature descriptors are used. To address this challenge, this paper reports a novel distorted Binary Robust Independent Elementary Feature (BRIEF) descriptor for fisheye images based on a spherical perspective model. Firstly, the 3D gray centroid of feature points is designed, and the position and direction of the feature points on the spherical image are described by a constructed feature point attitude matrix. Then, based on the attitude matrix of feature points, the coordinate mapping relationship between the BRIEF descriptor template and the fisheye image is established to realize the computation associated with the distorted BRIEF descriptor. Four experiments are provided to test and verify the invariance and matching performance of the proposed descriptor for a fisheye image. The experimental results show that the proposed descriptor works well for distortion invariance and can significantly improve the matching performance in fisheye images.

Nonlinear Modeling of Cortical Responses to Mechanical Wrist Perturbations Using the NARMAX Method.

OBJECTIVE: Nonlinear modeling of cortical responses (EEG) to wrist perturbations allows for the quantification of cortical sensorimotor function in healthy and neurologically impaired individuals. A common model structure reflecting key characteristics shared across healthy individuals may provide a reference for future clinical studies investigating abnormal cortical responses associated with sensorimotor impairments. Thus, the goal of our study is to identify this common model structure and therefore to build a nonlinear dynamic model of cortical responses, using nonlinear autoregressive-moving-average model with exogenous inputs (NARMAX). METHODS: EEG was recorded from ten participants when receiving continuous wrist perturbations. A common model structure detection method was developed for identifying a common NARMAX model structure across all participants, with individualized parameter values. The results were compared to conventional subject-specific models. RESULTS: The proposed method achieved 93.91% variance accounted for (VAF) when implementing a one-step-ahead prediction and around 50% VAF for a k-step ahead prediction (k = 3), without a substantial drop of VAF as compare to subject-specific models. The estimated common structure suggests that the measured cortical response is a mixed outcome of the nonlinear transformation of external inputs and local neuronal interactions or inherent neuronal dynamics at the cortex. CONCLUSION: The proposed method well determined the common characteristics across subjects in the cortical responses to wrist perturbations. SIGNIFICANCE: It provides new insights into the human sensorimotor nervous system in response to somatosensory inputs and paves the way for future translational studies on assessments of sensorimotor impairments using our modeling approach.

LdsConv: Learned Depthwise Separable Convolutions by Group Pruning.

Standard convolutional filters usually capture unnecessary overlap of features resulting in a waste of computational cost. In this paper, we aim to solve this problem by proposing a novel Learned Depthwise Separable Convolution (LdsConv) operation that is smart but has a strong capacity for learning. It integrates the pruning technique into the design of convolutional filters, formulated as a generic convolutional unit that can be used as a direct replacement of convolutions without any adjustments of the architecture. To show the effectiveness of the proposed method, experiments are carried out using the state-of-the-art convolutional neural networks (CNNs), including ResNet, DenseNet, SE-ResNet and MobileNet, respectively. The results show that by simply replacing the original convolution with LdsConv in these CNNs, it can achieve a significantly improved accuracy while reducing computational cost. For the case of ResNet50, the FLOPs can be reduced by 40.9%, meanwhile the accuracy on the associated ImageNet increases.

A Parametric Time-Frequency Conditional Granger Causality Method Using Ultra-Regularized Orthogonal Least Squares and Multiwavelets for Dynamic Connectivity Analysis in EEGs.

OBJECTIVE: This study proposes a new parametric time-frequency conditional Granger causality (TF-CGC) method for high-precision connectivity analysis over time and frequency domain in multivariate coupling nonstationary systems, and applies it to source electroencephalogram (EEG) signals to reveal dynamic interaction patterns in oscillatory neocortical sensorimotor networks. METHODS: The Geweke's spectral measure is combined with the time-varying autoregressive with exogenous input (TVARX) modeling approach, which uses multiwavelet-based ultra-regularized orthogonal least squares (UROLS) algorithm, aided by adjustable prediction error sum of squares (APRESS), to obtain high-resolution time-varying CGC representations. The UROLS-APRESS algorithm, which adopts both the regularization technique and the ultra-least squares criterion to measure not only the signal themselves, but also the weak derivatives of them, is a novel powerful method in constructing time-varying models with good generalization performance, and can accurately track smooth and fast changing causalities. The generalized measurement based on CGC decomposition is able to eliminate indirect influences in multivariate systems. RESULTS: The proposed method is validated on two simulations, and then applied to source level motor imagery (MI) EEGs, where the predicted distributions are well recovered with high TF precision, and the detected connectivity patterns of MI-EEGs are physiologically interpretable and yield new insights into the dynamical organization of oscillatory cortical networks. CONCLUSION: Experimental results confirm the effectiveness of the TF-CGC method in tracking rapidly varying causalities of EEG-based oscillatory networks. SIGNIFICANCE: The novel TF-CGC method is expected to provide important information of neural mechanisms of perception and cognition.

Distractor-Aware Deep Regression for Visual Tracking.

In recent years, regression trackers have drawn increasing attention in the visual-object tracking community due to their favorable performance and easy implementation. The tracker algorithms directly learn mapping from dense samples around the target object to Gaussian-like soft labels. However, in many real applications, when applied to test data, the extreme imbalanced distribution of training samples usually hinders the robustness and accuracy of regression trackers. In this paper, we propose a novel effective distractor-aware loss function to balance this issue by highlighting the significant domain and by severely penalizing the pure background. In addition, we introduce a full differentiable hierarchy-normalized concatenation connection to exploit abstractions across multiple convolutional layers. Extensive experiments were conducted on five challenging benchmark-tracking datasets, that is, OTB-13, OTB-15, TC-128, UAV-123, and VOT17. The experimental results are promising and show that the proposed tracker performs much better than nearly all the compared state-of-the-art approaches.

A Pilot Study Investigating a Novel Non-Linear Measure of Eyes Open versus Eyes Closed EEG Synchronization in People with Alzheimer's Disease and Healthy Controls

BACKGROUND: The incidence of Alzheimer disease (AD) is increasing with the ageing population. The development of low cost non-invasive diagnostic aids for AD is a research priority. This pilot study investigated whether an approach based on a novel dynamic quantitative parametric EEG method could detect abnormalities in people with AD. METHODS: 20 patients with probable AD, 20 matched healthy controls (HC) and 4 patients with probable fronto temporal dementia (FTD) were included. All had detailed neuropsychology along with structural, resting state fMRI and EEG. EEG data were analyzed using the Error Reduction Ratio-causality (ERR-causality) test that can capture both linear and nonlinear interactions between different EEG recording areas. The 95% confidence intervals of EEG levels of bi-centroparietal synchronization were estimated for eyes open (EO) and eyes closed (EC) states. RESULTS: In the EC state, AD patients and HC had very similar levels of bi-centro parietal synchronization; but in the EO resting state, patients with AD had significantly higher levels of synchronization (AD = 0.44; interquartile range (IQR) 0.41 vs. HC = 0.15; IQR 0.17, p < 0.0001). The EO/EC synchronization ratio, a measure of the dynamic changes between the two states, also showed significant differences between these two groups (AD ratio 0.78 versus HC ratio 0.37 p < 0.0001). EO synchronization was also significantly different between AD and FTD (FTD = 0.075; IQR 0.03, p < 0.0001). However, the EO/EC ratio was not informative in the FTD group due to very low levels of synchronization in both states (EO and EC). CONCLUSION: In this pilot work, resting state quantitative EEG shows significant differences between healthy controls and patients with AD. This approach has the potential to develop into a useful non-invasive and economical diagnostic aid in AD.

Time-Varying System Identification Using an Ultra-Orthogonal Forward Regression and Multiwavelet Basis Functions With Applications to EEG.

A new parametric approach is proposed for nonlinear and nonstationary system identification based on a time-varying nonlinear autoregressive with exogenous input (TV-NARX) model. The TV coefficients of the TV-NARX model are expanded using multiwavelet basis functions, and the model is thus transformed into a time-invariant regression problem. An ultra-orthogonal forward regression (UOFR) algorithm aided by mutual information (MI) is designed to identify a parsimonious model structure and estimate the associated model parameters. The UOFR-MI algorithm, which uses not only the observed data themselves but also weak derivatives of the signals, is more powerful in model structure detection. The proposed approach combining the advantages of both the basis function expansion method and the UOFR-MI algorithm is proved to be capable of tracking the change of TV parameters effectively in both numerical simulations and the real EEG data.

Correlation between tumor-associated macrophages and the occurrence and development of Kazakh esophageal squamous cell carcinoma in Xinjiang / 西安交通大学学报(医学版)

Objective To investigate the correlation between tumor-associated macrophages(TAMs)and the occurrence and progression of Kazakh esophageal squamous cell carcinoma.Methods We collected 200 cases of esophageal squamous cell carcinoma(ESCC),cancer adjacent normal(CAN)tissues and clinical pathological data of the specimens.CD68 was used as the TAM marker,and immunohistochemistry(IHC)counts were used to detect the distribution of TAMs and quantify the density of TAMs in tumor nest/epithelial and surrounding stroma.At the same time,by combining with clinical pathological data and the patients' prognosis,we analyzed whether the high density of TAMs distribution was associated with the occurrence and development of Kazakh ESCC and the patients' poor prognosis.Results ① The density of TAMs in the tumor nests and stroma was significantly higher than that in CAN tissues(P＜0.05).② The density of TAMs in tumor nest had a significant positive correlation with lymph node metastasis and clinical pathological stage(advanced)in Kazakh ESCC(P＜ 0.05),and this correlation was more evident between the density of TAMs in tumor stroma and lymph node metastasis and clinical pathological stage (advanced)(P＜0.001).③ The survival analysis found that the high density of CD 68-positive TAMs in cancer nest showed a positive correlation with poor prognosis of ESCC(P＜0.05).Conclusion High density of TAMs can promote the occurrence and development of Kazakh ESCC in Xinjiang and can be used as a poor prognostic factor for ESCC in Kazakh population.

Comparison of differences of Notch1 gene methylation between hyperplastic lesions tissues and breast cancer tissues in Uyghur women / 临床与实验病理学杂志

Purpose To compare the difference of Notch1 methylation in the breast cancer and hyperplastic lesions tissue from Uyghur in Xinjiang. Methods The methylation level of Notch1 gene in Uyghur breast tissues including usual ductal hyperplasia (UDH), atypical ductal hyperplasia (ADH), ductal carcinoma in situ (DCIS), and invasive ductal carcinoma(IDC) were detected by MALDI-TOF-MS technique. The association of the methylation level with clinical pathological characteristics of patients was analyzed. The expression of Notch 1 protein was detected by immunohistochemistry. The relationship between the methylation status and expression was assay. Results The methylation rate of Notch l gene in UDH, ADH, DCIS, and IDC group was gradually decreased (P＜0.05). The 9 CpG sites methylation level of 13 CpG sites are statistically lower in cancer tissues (P＜0.05). The hypomethylation are accompanied with low differentiation, lymph node metastasis and high stage of TNM (P＜0.05). The lower DNA methylation is negatively correlated with the expression of Notch l (P＜0.05). Conclusion There was a differences of the expression and methylation rate of Notch 1 between breast cancer and hyperplastic lesions tissue, and its biological significances needs to be further studied.

Expression of MAP3K3 mRNA and its prognosis in human ovarian carcinoma / 临床与实验病理学杂志

Purpose To investigate the expression of mitogen-activated protein kinase kinase kinase 3 (MAP3K3) mRNA in ovarian carcinoma patients and to explore the correlation among its expression, clinicopathological features and prognosis. Methods The expression of MAP3K3 mRNA in ovarian carcinoma and fallopian tube tissues were detected by qRT-PCR, and the correlation between MAP3K3 mRNA expression and clinicopathological features was also analyzed. Whether MAP3K3 mRNA expression could be used as an independent predictor of prognosis for patients with ovarian carcinoma was further determined. Results The expression of MAP3K3 mRNA in ovarian carcinoma was significantly higher than that in fallopian tube tissues (P＜0.05). High expression of MAP3K3 mRNA was significantly correlated with FIGO stage and Challenge model of ovarian carcinoma (P＜0.05). Kaplan-Meier survival analysis showed that the disease-free survival time and overall survival time of patients with high MAP3K3 mRNA expression were shorter than those with low expression (34 months vs 52.2 months, P＜0.05.38.6 months vs 52.5 months, P＜0.05). Univariate analysis showed that high expression of MAP3K3 mRNA was a risk factor for poor prognosis of ovarian carcinoma patients (HR=4.198, 95％C/: 1.711 ～10.302, P＜0.05). Conclusion MAP3K3 mRNA is highly expressed in ovarian carcinoma tissues. Its high expression is associated with FIGO stage, Challenge model and poor prognosis of ovarian carcinoma, which may involve in the malignant transformation of ovarian carcinoma.

Quantifying heterogeneous responses of fish community size structure using novel combined statistical techniques.

To understand changes in ecosystems, the appropriate scale at which to study them must be determined. Large marine ecosystems (LMEs) cover thousands of square kilometres and are a useful classification scheme for ecosystem monitoring and assessment. However, averaging across LMEs may obscure intricate dynamics within. The purpose of this study is to mathematically determine local and regional patterns of ecological change within an LME using empirical orthogonal functions (EOFs). After using EOFs to define regions with distinct patterns of change, a statistical model originating from control theory is applied (Nonlinear AutoRegressive Moving Average with eXogenous input - NARMAX) to assess potential drivers of change within these regions. We have selected spatial data sets (0.5° latitude × 1°longitude) of fish abundance from North Sea fisheries research surveys (spanning 1980-2008) as well as of temperature, oxygen, net primary production and a fishing pressure proxy, to which we apply the EOF and NARMAX methods. Two regions showed significant changes since 1980: the central North Sea displayed a decrease in community size structure which the NARMAX model suggested was linked to changes in fishing; and the Norwegian trench region displayed an increase in community size structure which, as indicated by NARMAX results, was primarily linked to changes in sea-bottom temperature. These regions were compared to an area of no change along the eastern Scottish coast where the model determined the community size structure was most strongly associated to net primary production. This study highlights the multifaceted effects of environmental change and fishing pressures in different regions of the North Sea. Furthermore, by highlighting this spatial heterogeneity in community size structure change, important local spatial dynamics are often overlooked when the North Sea is considered as a broad-scale, homogeneous ecosystem (as normally is the case within the political Marine Strategy Framework Directive).

A nonlinear generalization of spectral Granger causality.

Spectral measures of linear Granger causality have been widely applied to study the causal connectivity between time series data in neuroscience, biology, and economics. Traditional Granger causality measures are based on linear autoregressive with exogenous (ARX) inputs models of time series data, which cannot truly reveal nonlinear effects in the data especially in the frequency domain. In this study, it is shown that the classical Geweke's spectral causality measure can be explicitly linked with the output spectra of corresponding restricted and unrestricted time-domain models. The latter representation is then generalized to nonlinear bivariate signals and for the first time nonlinear causality analysis in the frequency domain. This is achieved by using the nonlinear ARX (NARX) modeling of signals, and decomposition of the recently defined output frequency response function which is related to the NARX model.

A nonlinear causality measure in the frequency domain: nonlinear partial directed coherence with applications to EEG.

BACKGROUND: Frequency domain Granger causality measures have been proposed and widely applied in analyzing rhythmic neurophysiological and biomedical signals. Almost all these measures are based on linear time domain regression models, and therefore can only detect linear causal effects in the frequency domain. NEW METHOD: A frequency domain causality measure, the partial directed coherence, is explicitly linked with the frequency response function concept of linear systems. By modeling the nonlinear relationships between time series using nonlinear models and employing corresponding frequency-domain analysis techniques (i.e., generalized frequency response functions), a new nonlinear partial directed coherence method is derived. RESULTS: The advantages of the new method are illustrated via a numerical example of a nonlinear physical system and an application to electroencephalogram signals from a patient with childhood absence epilepsy. COMPARISON WITH EXISTING METHODS: The new method detects both linear and nonlinear casual effects between bivariate signals in the frequency domain, while the existing measures can only detect linear effects. CONCLUSIONS: The proposed new method has important advantages over the classical linear measures, because detecting nonlinear dependencies has become more and more important in characterizing functional couplings in neuronal and biological systems.

Quantitative EEG analysis using error reduction ratio-causality test; validation on simulated and real EEG data.

OBJECTIVE: To introduce a new method of quantitative EEG analysis in the time domain, the error reduction ratio (ERR)-causality test. To compare performance against cross-correlation and coherence with phase measures. METHODS: A simulation example was used as a gold standard to assess the performance of ERR-causality, against cross-correlation and coherence. The methods were then applied to real EEG data. RESULTS: Analysis of both simulated and real EEG data demonstrates that ERR-causality successfully detects dynamically evolving changes between two signals, with very high time resolution, dependent on the sampling rate of the data. Our method can properly detect both linear and non-linear effects, encountered during analysis of focal and generalised seizures. CONCLUSIONS: We introduce a new quantitative EEG method of analysis. It detects real time levels of synchronisation in the linear and non-linear domains. It computes directionality of information flow with corresponding time lags. SIGNIFICANCE: This novel dynamic real time EEG signal analysis unveils hidden neural network interactions with a very high time resolution. These interactions cannot be adequately resolved by the traditional methods of coherence and cross-correlation, which provide limited results in the presence of non-linear effects and lack fidelity for changes appearing over small periods of time.

A parametric method to measure time-varying linear and nonlinear causality with applications to EEG data.

A linear and nonlinear causality detection method called the error-reduction-ratio causality (ERRC) test is introduced in this paper to investigate if linear or nonlinear models should be considered in the study of human electroencephalograph (EEG) data. In comparison to the traditional Granger methods, one significant advantage of the ERRC approach is that it can effectively detect the time-varying linear and nonlinear causalities between two signals without fitting a complete nonlinear model. Two numerical simulation examples are employed to compare the performance of the new method with other widely used methods in the presence of noise and in tracking time-varying causality. Finally, an application to measure the linear and nonlinear relationships between two EEG signals from different cortical sites for patients with childhood absence epilepsy is discussed.