[Role of LNK gene mutation in pathogenesis of myeloproliferative neoplasms-review].

Myeloproliferative neoplasms ( MPN ) is a class of clonal hematopoietic stem cell disease. Studies found that the JAK-STAT signaling pathway is closely related to the pathogenesis of MPN. The lymphocyte-specific adaptor protein (LNK) gene negatively regulates Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling and may play an important role in the pathogenesis of MPN. Especially in JAK2 mutation-negative MPN, LNK gene specific mutations may be the key to cause MPN subtypes. Certain single nucleotide polymorphism of LNK gene regulation of hematopoietic cells in different directions may also be important influence factors of MPN performance for different subtypes. LNK gene functional changes lead to abnormal activation of the JAK-STAT signaling pathway, and may be a new mechanism of MPN. In this review, the role of LNK gene in MPN pathogenesis is briefly summarized.

The contrastive study on lip profile of malocclusion of Class I, II and II in Harbin / 华西口腔医学杂志

<p><b>OBJECTIVE</b>To get reference for the diagnosis design and the clinical diagnosis, the difference is compared among lip profile on malocclusion of Class I, II and III from patients in Harbin, and the relationship is established between the linear cephalometric measurements and the regional cephalometric measurements.</p><p><b>METHODS</b>120 female patients, 18-25 years old, were selected. According to the value of / ANB which was measured on the pre-treatment cephalographs, they were divided into three groups--Class I, II and III. Each group had 40 patients. Each patient had the same type of skeletal pattern and occlusion pattern, and then 21 lip soft tissues were measured. Finally, the results of measurements were statistically analyzed with ANOVA and were compared between members in each group via SPSS 13.0 software.</p><p><b>RESULTS</b>The differences among patients with lip profile on malocclusion had statistic significances (P < 0.05). In order of Class II, I and III, the UL-E, ULP, ULP-LLP, Sn-Ns-B' and S4 were progressively decreased and the B'-LL-FH, S-Ns-B' and S1 were increased. In order of Class II, III and I, the LL-B'-Pos and Z-angle were raised and LL-E was reduced. The length of the upper lip and the lower lip had no statistic significance (P > 0.05).</p><p><b>CONCLUSION</b>There is difference among the Class I, II and III. The lip covering area is inclined to decrease the changes of the upper lip and increase the changes of the lower lip progressively with the variation of skeletal patterns in order of Class II, I, and III. Moreover, the condition of lip tissues can be accurately presented by the regional cephalometric measurements.</p>