ABSTRACT
Objective To construct a scenario database for high altitude military medical comprehensive exercises to enhance the training efficiency.Methods Related documents were used as guidelines for construction.Information technologies were used as construction support.The hierarchical model was used as a technical framework.JAVA,Linux,Oracle and Tomcat were used as development tools.Results First,the foundation of the system was elaborated regarding of guiding ideology,construction principles and standards.Second,the architectural design of the system was stated around the functional framework,technical framework and information framework.Third,the implementation of the system was outlined in terms of development tools and function modules.Conclusion The scenario database can provide standard data resources for related simulation training systems and perfect scenario support for high altitude health service training,which can contribute to the training reform and the improvement of training quality.
ABSTRACT
In this study, prognostic value of cerebrospinal fluid (CSF) free fatty acid (FFA) levels in patients confirmed with acute ischemic stroke (AIS) was evaluated in a Chinese population. A prospective cohort designed study was conducted at our hospital of the Emergency department from November, 2012 to September, 2014. The National Institutes of Health Stroke Scale (NIHSS) score on admission was applied to assess CSF levels of FFA and specific severity degree of stroke. Evaluation of the prognostic outcomes of those stroke patients used the modified Rankin scale scores at 90-days. Logistic regression analysis analyzed the prognostic value of FFA. NIHSS score results suggested a positive relationship between levels of CSF FFA levels and severity of stroke. There was an obviously higher trend of CSF FFA levels in patients with CE stroke than those of the non-CE stroke patients, with statistically difference (P < 0.05). Further, CSF FFA levels were evidently lower in those 73 patients with favorable outcome when compared to those with unfavorable outcomes [0.21(IQR, 0.11-0.28) mmol/L vs. 0.36 (IQR, 0.27-0.50) mmol/L, P < 0.0001, P < 0.0001]. Multivariate analysis results after possible confounders adjustment indicated that there was an increased risk of unfavorable outcome associated with CSF FFA levels ≥0.29 mmol/L (OR 5.12, 95%CI: 2.35-10.28; P < 0.0001). Collectively, CSF level of FFA at admission was suggested to be a useful, independent short-term prognostic marker in Chinese patient with AIS.
ABSTRACT
Current trends in nanotechnology and RNA interference technology have made the application of nanocarriers (NCS) as a novel gene and drug delivery systems very promising for the field of multidrug resistance (MDR) cancer treatment. Co-delivery of gene and chemotherapy drugs with NCS has a good synergistic effect compared with the traditional chemotherapy which can increase the amount of the drug distribution in target organ in order to reduce the toxic side effects thereby enhancing efficacy. Therefore, the advent of co-delivery systems with NCS especially in the clinical treatment of MDR has had a significant impact on the cancer treatment.
Subject(s)
Humans , Antineoplastic Agents , Therapeutic Uses , Drug Carriers , Drug Delivery Systems , Drug Resistance, Multiple , Drug Resistance, Neoplasm , Genetic Therapy , Methods , Nanostructures , Chemistry , Nanotechnology , Methods , Neoplasms , Genetics , Therapeutics , RNA Interference , RNA, Small Interfering , GeneticsABSTRACT
Despite recent advances in conventional therapeutic approaches for cancer, the efficacy of chemotherapy for cancer is limited due to the drug resistance and toxic side effects during treatment. To overcome drug resistance, higher doses of the toxic chemotherapy drugs are frequently administered, thus leading to even severe adverse side effects, which have limited their clinical application. Cationic liposome as a novel non-viral carrier for co-delivery of gene and chemotherapy drugs in cancer gene therapy has already attracted more and more attention in recent years. Most importantly, this combined strategy can generate a significant synergistic effect, which can silence the related gene expression and increase the concentration of the intracellular chemotherapy drugs. This approach allows the use of a much lower dose of the chemotherapy drugs to achieve same therapeutic effect, which may have the potential for overcoming some major limitations of the conventional chemotherapy. In conclusion, co-delivery of gene and chemotherapy drugs with cationic liposome delivery system will play a vital role in the future and especially could be a promising clinical treatment for drug-resistant tumors.
Subject(s)
Animals , Humans , Antineoplastic Combined Chemotherapy Protocols , Therapeutic Uses , Cations , Cell Line, Tumor , DNA , Genetics , Drug Carriers , Drug Delivery Systems , Gene Transfer Techniques , Genetic Therapy , Methods , Liposomes , Chemistry , Neoplasms , Therapeutics , RNA, Small Interfering , GeneticsABSTRACT
<p><b>OBJECTIVE</b>To investigate the chemical constituents of the bulbs of Bolbostemma panicultum.</p><p><b>METHOD</b>The compounds were isolated by column chromatography on silica gel, C18, Sephadex LH-20 separately and their structures were elucidated by chemical and spectroscopic technologies.</p><p><b>RESULT</b>Eight compounds were isolated and identified as maltol(I), emodin(II), cucurbitacin B(III), cucurbitacin E(IV), stigmasta-7, 22, 25-triene-3-ol(V), stigmasta-7, 22, 25-triene-3-nonadecanoic acid ester(VI), stigmasta-7, 22, 25-triene-3-O-beta-D-glucopyranoside(VII), stigmasta-7, 22, 25-triene-3-O-beta-D-(6'-palmitoyl) glucopyranoside(VIII).</p><p><b>CONCLUSION</b>I-VIII were obtained from this plant for the first time; VI and VIII are new compounds.</p>
