ABSTRACT
Alendronate is a bisphosphonate used in treating osteoporosis. Its recognized side-effects include oesophageal irritation and ulceration. The authors describe a case of laryngitis induced by transient contact of this medication with the laryngeal mucosa. Successful management of this case is also detailed.
Subject(s)
Alendronate/adverse effects , Laryngitis/chemically induced , Aged , Female , Humans , Laryngeal Mucosa/drug effects , Osteoporosis, Postmenopausal/drug therapyABSTRACT
Carcinoid tumours of the larynx are extremely rare, only 13 cases having previously been reported in the world literature. A case is reported here with the unusual complication of skin metastases. The true diagnosis is seldom made on the original biopsy, which is commonly reported as poorly differentiated carcinoma. A review of the literature is made with a discussion of the histological diagnosis and treatment modalities.
Subject(s)
Carcinoid Tumor/secondary , Laryngeal Neoplasms/diagnosis , Skin Neoplasms/secondary , Aged , Carcinoid Tumor/diagnosis , Carcinoid Tumor/pathology , Humans , Laryngeal Neoplasms/pathology , Male , Skin Neoplasms/pathologySubject(s)
Laryngeal Neoplasms/surgery , Laryngectomy , Adult , Aged , Female , Fistula/etiology , Humans , Laryngeal Neoplasms/mortality , Laryngeal Neoplasms/pathology , Male , Middle Aged , Neoplasm Recurrence, Local/surgery , Neoplasm Staging , Postoperative Complications , Retrospective Studies , TracheotomySubject(s)
Hypopharyngeal Neoplasms/therapy , Pharyngeal Neoplasms/therapy , Adult , Age Factors , Aged , Female , Humans , Hypopharyngeal Neoplasms/pathology , Hypopharyngeal Neoplasms/radiotherapy , Male , Middle Aged , Neoplasm Staging , Palliative Care , Prognosis , Retrospective Studies , Sex FactorsABSTRACT
Twenty-one total pharyngo-laryngectomies have been performed at the Manchester Royal Infirmary between 1968 and 1982. A variety of methods of repair have been used, gastric transposition being the most common. Seventeen patients had received previous radiotherapy to the area, fourteen radical, two palliative and one to a supraglottic carcinoma 12 years before. Four had tumours judged to be too large to benefit from radiotherapy. Of the patients who received radiotherapy, fourteen had a good response with palliation for an average of ten months before symptoms began to return. Four patients survived over five years post-operatively and ten died following surgery.
