ABSTRACT
The spinal cord was examined in two cases of progressive supranuclear palsy. In both cases, cells with neurofibrillary tangles were seen in the anterior horn, posterior horn, lateral horn, Clark's column, and intermediate gray. The tangles were most frequently observed in the posterior horn. The results suggest that the spinal cord is involved in the pathological process of progressive supranuclear palsy.
Subject(s)
Neurofibrils/pathology , Spinal Cord/pathology , Supranuclear Palsy, Progressive/pathology , Aged , Amyotrophic Lateral Sclerosis/pathology , Anterior Horn Cells/pathology , Female , Humans , Middle Aged , Spinal Nerve Roots/pathologyABSTRACT
A neurofibroma, a fibroma, a primary neurofibrosarcoma, and four neurofibrosarcoma metastases from a woman with hereditary neurofibromatosis who was heterozygous (GdB/GdA-) for the X-linked enzyme glucose-6-phosphate dehydrogenase were studied to determine the number of cells from which the tumors developed. Both enzyme types were observed in the benign tumors in proportions similar to those present in seven different normal tissues studied. These findings indicated that the benign tumors arose from many cells. In marked contrast, only type A activity was detected in the primary neurofibrosarcoma and in all of the metastases. Two or more steps probably were involved in the development of neurofibrosarcoma in this patient: the inherited genetic mutation producing neurofibromatosis and a rare event or combination of events that permitted a single cell to undergo malignant proliferation.
Subject(s)
Neurofibromatosis 1/genetics , Adult , Cell Transformation, Neoplastic , Clone Cells/enzymology , Female , Glucosephosphate Dehydrogenase/genetics , Humans , Isoenzymes/genetics , Liver Neoplasms/secondary , Lung Neoplasms/secondary , Neurofibromatosis 1/pathologyABSTRACT
Nodular regenerative hyperplasia of the liver was identified at autopsy in a patient with myelofibrosis with extramedulary hematopoiesis, an association not previously reported. Portal venous hypertension, documented during the patient's terminal hospitalization, was ascribed, in part, to a high rate of blood flow through the enlarged spleen. Possible mechanisms accounting for the development of nodular regenerative hyperplasia of the liver, and evidence provided by this case pertinent to these mechanisms, are discussed.
Subject(s)
Hematopoiesis , Hypertension, Portal/etiology , Liver/pathology , Primary Myelofibrosis/complications , Autopsy , Humans , Hyperplasia , Hypertension, Portal/pathology , Male , Middle Aged , Primary Myelofibrosis/pathologyABSTRACT
A "false-positive" 99mTc-stannous pyrophosphate (99mTc-PYP) myocardial image was seen in a patient with epidermoid carcinoma of the lung. The location of the increased activity corresponded to an area of direct invasion of the heart by carcinoma with associated multiple microscopic foci of myocardial necrosis. Metastatic carcinoma with myocardial necrosis should therefore be considered as a possible cause of a positive 99mTc-PYP myocardial image.
