Subject(s)
Anaphylaxis/chemically induced , Antiemetics/adverse effects , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Ondansetron/adverse effects , Ovarian Neoplasms/drug therapy , Premedication , Anaphylaxis/diagnosis , Antiemetics/therapeutic use , Antineoplastic Combined Chemotherapy Protocols/adverse effects , Female , Humans , Middle Aged , Ondansetron/therapeutic useSubject(s)
Tonsillectomy/adverse effects , Voice Disorders/etiology , Adenoidectomy/adverse effects , Adult , Female , Humans , Voice QualitySubject(s)
Bone Neoplasms/diagnosis , Hemangioma/diagnosis , Magnetic Resonance Imaging , Tibia , Biopsy , Bone Neoplasms/diagnostic imaging , Bone Neoplasms/pathology , Diagnosis, Differential , Female , Hemangioma/diagnostic imaging , Hemangioma/pathology , Humans , Middle Aged , Radionuclide ImagingABSTRACT
A patient with a pleomorphic intravascular leiomyosarcoma of the great vessels of the neck and mediastinum presented clinically with a superior vena cava syndrome. A latent period of 29 years elapsed between receiving orthovoltage radiation to the neck and right side of chest to treat recurrent ganglioneuroblastoma, and the appearance of a leiomyosarcoma and subsequent recurrences. The patient underwent partial resection of the tumor, received adjunct chemotherapy, and was shown to be free of disease by clinical tests and by magnetic resonance imaging (MRI) 17 months after completion of chemotherapy. The criteria for the diagnosis of radiation-induced sarcomas are reviewed in relation to the present case. The critical role of magnetic resonance imaging in both the diagnosis and continued follow-up of the patient is described. This would appear to be the first reported case of radiation-induced intravascular leiomyosarcoma of the great vessels of the neck and mediastinum presenting as a superior vena cava syndrome.
Subject(s)
Brachiocephalic Trunk , Leiomyosarcoma/etiology , Neoplasms, Radiation-Induced/diagnosis , Superior Vena Cava Syndrome/diagnosis , Adult , Diagnosis, Differential , Female , Ganglioneuroma/pathology , Ganglioneuroma/radiotherapy , Humans , Leiomyosarcoma/diagnosis , Leiomyosarcoma/pathology , Magnetic Resonance Spectroscopy , Mediastinal Neoplasms/pathology , Mediastinal Neoplasms/radiotherapy , Neoplasms, Radiation-Induced/pathologyABSTRACT
Two case studies are reported in which transient low frequency sensorineural hearing loss was experienced following myelography and CT scanning with metrizamide. Low frequency sensorineural hearing loss is considered to be the result of increased stiffness of one or both of the inner ear membranes. A review of the literature regarding an osmotic relationship between blood, cerebrospinal fluid, and the inner ear fluids attempts to explain how this phenomenon may have occurred with metrizamide. The transient sensorineural loss observed in the case studies presented is compared to the pathophysiology attributed to the formation of endolymphatic hydrops.
Subject(s)
Hearing Loss, Sensorineural/chemically induced , Metrizamide/adverse effects , Adult , Aged , Cochlea/drug effects , Cochlea/physiopathology , Female , Hearing Loss, Bilateral/chemically induced , Humans , Male , Meniere Disease/physiopathology , Myelography , Tomography, X-Ray ComputedSubject(s)
Airway Obstruction/therapy , Airway Obstruction/diagnosis , Airway Obstruction/etiology , Child , Child, Preschool , Craniofacial Dysostosis/complications , Craniofacial Dysostosis/surgery , Emergencies , Humans , Infant , Infant, Newborn , Klippel-Feil Syndrome/complications , Klippel-Feil Syndrome/surgery , Mandibulofacial Dysostosis/complications , Mandibulofacial Dysostosis/surgery , Pierre Robin Syndrome/complications , Pierre Robin Syndrome/therapy , TracheotomyABSTRACT
Lightning induced damage to the ear is multifaceted. The seventh and eighth cranial nerves, the labyrinthine system, and the tympanic membrane are most commonly injured. A case report demonstrating all these injuries is presented.
Subject(s)
Electric Injuries/complications , Facial Nerve Injuries , Lightning , Tympanic Membrane/injuries , Vestibulocochlear Nerve Injuries , Ataxia/etiology , Electric Injuries/diagnosis , Electric Injuries/rehabilitation , Facial Paralysis/etiology , Facial Paralysis/rehabilitation , Female , Humans , Middle Aged , Time FactorsABSTRACT
Twenty-three consecutive tracheotomies were cultured after an apparent outbreak of Serratia marcescens was noted. Over a period of one year, six cases with positive cultures were found. The importance of these positive cultures in relation to the patient's clinical course is discussed. The treatment of Serratia marcescens septicemia is reviewed.
