Longitudinal changes in central corneal thickness and their relation to glaucoma status: an 8 year follow up study.

AIMS: To determine if central corneal thickness (CCT) changes over time and if this change relates to glaucoma progression. METHODS: 39 patients (64 eyes) with open angle glaucoma, ocular hypertension, glaucoma suspect status, or a normal eye examination were examined at two visits. CCT, age, race, sex, family history of glaucoma, presence of diabetes and systemic hypertension, diagnosis, visual acuity, spherical equivalent, intraocular pressure, vertical and horizontal cup to disc ratios, number of glaucoma medications prescribed, Advanced Glaucoma Intervention Study (AGIS) score and mean deviation of Humphrey visual fields, and interventions required were recorded. Statistical analysis used the Wilcoxon signed ranks test, linear regression, and analysis of variance. RESULTS: Between the two visits (mean 8.2 years apart), mean CCT decreased by 17 mum in right eyes (p<0.002) and by 23 mum in left eyes (p<0.001). This decrease was greater in right eyes of patients with primary open angle glaucoma than in normals (p = 0.041). There was no significant association between change in CCT and other examination parameters. Change in CCT was not associated with topical carbonic anhydrase inhibitor use. CONCLUSION: In this longitudinal study, CCT decreased over time, but this may not be related to glaucoma progression.

Myasthenia gravis with ocular involvement in older patients.

BACKGROUND: There has been little previous study reporting the eye findings and presentation of elderly patients with myasthenia gravis. The purpose of this study was to review the findings and course of myasthenia gravis after the sixth decade of life. METHODS: Retrospective observational case series. The authors reviewed the clinical records of 27 patients with onset of myasthenia gravis at age 60 years or more who were seen at a tertiary care academic ophthalmology centre in Houston between January 1992 and March 1999. The diagnosis of myasthenia gravis was based on conventional clinical and laboratory criteria. RESULTS: Twenty patients (74%) were men. Of the 16 patients who underwent testing for anti-acetylcholine receptor antibodies, 11 (69%) were seropositive. Concurrent thyroid disease was found in seven patients (26%), including five (71%) of the seven women. No patient had thymoma. Sixteen patients (59%) manifested generalized symptoms during follow-up; 12 did so within 1 year of disease onset. Patients responded well to both anticholinesterase and corticosteroid therapy. At the most recent follow-up visit 18 patients (67%) were clinically improved, and no patient was clinically worse. INTERPRETATION: Myasthenia gravis in this study was characterized by a male predominance, high rate of concurrent thyroid disease, high rate of progression to mild generalized symptoms, absence of thymoma, good response to medical therapy and minimal life-threatening complications. Clinicians should consider the diagnosis of myasthenia gravis in an older patient presenting with diplopia or ptosis.

Vision loss as the presenting sign in juvenile neuronal ceroid lipofuscinosis.

OBJECTIVE: To review cases of juvenile neuronal ceroid lipofuscinosis (JNCL) and highlight salient clinical and diagnostic features, thereby enhancing recognition of this disease among ophthalmologists. MATERIALS AND METHODS: Twelve cases of JNCL seen from 1982 to 1999 were reviewed. Diagnosis was based on characteristic clinical history, ophthalmoscopic findings, electroretinography, neuroimaging, histopathology, and molecular analysis. RESULTS: Vision loss was the first subjective symptom of the disease in all 12 cases. Among these cases, nine of 12 patients (75%) developed neurologic deficits an average of 3 years after the onset of visual deterioration. CONCLUSION: Because visual symptoms usually precede neurologic dysfunction, JNCL should be considered in the differential diagnosis when an apparently healthy child presents with unexplained bilateral vision loss.