1.
Vet Rec
; 118(21): 588-9, 1986 May 24.
Article
in English
| MEDLINE
| ID: mdl-3526698
Subject(s)
Naphthoquinones/therapeutic use , Theileriasis/drug therapy , Animals , Cattle , Clinical Trials as Topic , Kenya
2.
Res Vet Sci
; 39(1): 29-33, 1985 Jul.
Article
in English
| MEDLINE
| ID: mdl-3929346
ABSTRACT
A series of hydroxynaphthoquinones, all derivatives of the antitheilerial hydroxynaphthoquinone parvaquone (993C, Clexon; Wellcome) was tested for antitheilerial activity against Theileria parva (Muguga) in vitro. BW720C (buparvaquone) was 20 times more active than parvaquone. When tested in vivo BW720C cured all 13 cattle infected with T parva and all six infected with T annulata treated at a dose rate of 2.5 mg (kg bodyweight)-1 while parvaquone at 20 mg kg-1 cured nine of 10 cattle. All 16 untreated control cattle died of theileriosis.