Effects of whole-body vibration on reproductive physiology in a rat model of whole-body vibration.

Findings from epidemiological studies suggest that occupational exposure to whole-body vibration (WBV) may increase the risk of miscarriage and contribute to a reduction in fertility rates in both men and women. However, workers exposed to WBV may also be exposed to other risk factors that contribute to reproductive dysfunction. The goal of this experiment was to examine the effects of WBV on reproductive physiology in a rat model. Male and female rats were exposed to WBV at the resonant frequency of the torso (31.5 Hz, 0.3 g amplitude) for 4 hr/day for 10 days. WBV exposure resulted in a significant reduction in number of developing follicles, and decrease in circulating estradiol concentrations, ovarian luteinizing hormone receptor protein levels, and marked changes in transcript levels for several factors involved in follicular development, cell cycle, and steroidogenesis. In males, WBV resulted in a significant reduction in spermatids and circulating prolactin levels, elevation in number of males having higher circulating testosterone concentrations, and marked alterations in levels of transcripts associated with oxidative stress, inflammation, and factors involved in regulating the cell cycle. Based upon these findings data indicate that occupational exposure to WBV contributes to adverse alterations in reproductive physiology in both genders that may lead to reduction in fertility.

The effects of feed force on rivet bucking bar vibrations.

Percussive riveting is the primary process for attaching the outer sheet metal "skins" of an aircraft to its airframe. Workers using manually-operated riveting tools (riveting hammers and rivet bucking bars) are exposed to significant levels of hand-transmitted vibration (HTV) and are at risk of developing components of hand-arm vibration syndrome (HAVS). To protect workers, employers can assess and select riveting tools that produce reduced HTV exposures. Researchers at the National Institute for Occupational Safety & Health (NIOSH) have developed a laboratory-based apparatus and methodology to evaluate the vibrations of rivet bucking bars. Using this simulated riveting approach, this study investigated the effects of feed force on the vibrations of several typical rivet bucking bars and that transmitted to the bucking bar operator's wrist. Five bucking bar models were assessed under three levels of feed force. The study results demonstrate that the feed force can be a major influencing factor on bucking bar vibrations. Similar feed force effects were observed at the bucking bar operator's wrist. This study also shows that different bucking bar designs will respond differently to variations in feed force. Some bucking bar designs may offer reduced vibration exposures to the bar operator's fingers while providing little attenuation of wrist acceleration. Knowledge of how rivet bucking bar models respond to riveting hammer vibrations can be important for making informed bucking bar selections. The study results indicate that, to help in the appropriate selection of bucking bars, candidate bar models should be evaluated at multiple feed force levels. The results also indicate that the bucking bar model, feed force level, or the bucking bar operator have no meaningful effects on the vibration excitation (riveting hammer), which further suggests that the test apparatus proposed by NIOSH researchers meets the basic requirements for a stable vibration source in laboratory-based bucking bar vibration assessments. This study provides relevant information that can be used to help develop a standardized laboratory-based bucking bar evaluation methodology and to help in the selection of appropriate bucking bars for various workplace riveting applications. RELEVANCE TO INDUSTRY: Because the feed force level can affect HTV exposures to bucking bar operators, the feed force required for specific riveting operations should be an important consideration when selecting bucking bar models. This study provides useful information about bucking bar responses to riveting hammer vibrations; this knowledge can improve bucking bar selections.

Antivibration gloves: effects on vascular and sensorineural function, an animal model.

Anti-vibration gloves have been used to block the transmission of vibration from powered hand tools to the user, and to protect users from the negative health consequences associated with exposure to vibration. However, there are conflicting reports as to the efficacy of gloves in protecting workers. The goal of this study was to use a characterized animal model of vibration-induced peripheral vascular and nerve injury to determine whether antivibration materials reduced or inhibited the effects of vibration on these physiological symptoms. Rats were exposed to 4 h of tail vibration at 125 Hz with an acceleration 49 m/s(2). The platform was either bare or covered with antivibrating glove material. Rats were tested for tactile sensitivity to applied pressure before and after vibration exposure. One day following the exposure, ventral tail arteries were assessed for sensitivity to vasodilating and vasoconstricting factors and nerves were examined histologically for early indicators of edema and inflammation. Ventral tail artery responses to an α2C-adrenoreceptor agonist were enhanced in arteries from vibration-exposed rats compared to controls, regardless of whether antivibration materials were used or not. Rats exposed to vibration were also less sensitive to pressure after exposure. These findings are consistent with experimental findings in humans suggesting that antivibration gloves may not provide protection against the adverse health consequences of vibration exposure in all conditions. Additional studies need to be done examining newer antivibration materials.

An investigation on the biodynamic foundation of a rat tail vibration model.

The objectives of this study are to examine the fundamental characteristics of the biodynamic responses of a rat tail to vibration and to compare them with those of human fingers. Vibration transmission through tails exposed to three vibration magnitudes (1 g, 5 g, and 10 g r.m.s.) at six frequencies (32 Hz, 63 Hz, 125 Hz, 160 Hz, 250 Hz, and 500 Hz) was measured using a laser vibrometer. A mechanical-equivalent model of the tail was established on the basis of the transmissibility data, which was used to estimate the biodynamic deformation and vibration power absorption at several representative locations on the tail. They were compared with those derived from a mechanical-equivalent model of human fingers reported in the literature. This study found that, similar to human fingers, the biodynamic responses of the rat tail depends on the vibration magnitude, frequency, and measurement location. With the restraint method used in this study, the natural frequency of the rat tail is in the range 161-368 Hz, which is mostly within the general range of human finger resonant frequencies (100-350 Hz). However, the damping ratios of the rat tail at the unconstrained locations are from 0.094 to 0.394, which are lower than those of human fingers (0.708-0.725). Whereas the biodynamic responses of human fingers at frequencies lower than 100 Hz could be significantly influenced by the biodynamics of the entire hand-arm system, the rat tail biodynamic responses can be considered independent of the rat body in the frequency range used in this study. Based on these findings it is concluded that, although there are some differences between the frequency dependences of the biodynamic responses of the rat tail and human fingers, the rat tail model can provide a practical and reasonable approach to examine the relationships between the biodynamic and biological responses at midrange to high frequencies, and to understand the mechanisms underlying vibration-induced finger disorders.

An evaluation of impact wrench vibration emissions and test methods.

In the interest of providing more effective evaluations of impact wrench vibration exposures and the development of improved methods for measuring vibration emissions produced by these tools, this study focused on three variables: acceleration measured at the tool surface, vibration exposure duration per test trial, and the amount of torque required to unseat the nuts following a test trial. For this evaluation, six experienced male impact wrench operators used three samples each of five impact wrench models (four pneumatic models and one battery-powered model) in a simulated work task. The test setup and procedures were based on those provided by an International Organization for Standardization (ISO) Technical Committee overseeing the revision of ISO 8662-7. The work task involved the seating of 10 nuts onto 10 bolts mounted on steel plates. The results indicate that acceleration magnitudes vary not only by tool type but also by individual tools within a type. Thus, evaluators are cautioned against drawing conclusions based on small numbers of tools and/or tool operators. Appropriate sample sizes are suggested. It was further noted that evaluators could draw different conclusions if tool assessments are based on ISO-weighted acceleration as opposed to unweighted acceleration. As expected, vibration exposure durations varied by tool type and by test subject; duration means varied more for study participants than they did for tool types. For the 12 pneumatic tools evaluated in this study, torque varied directly with tool handle acceleration. Therefore, in order to reduce vibration exposure, tools should be selected and adjusted so that they produce no more than the needed torque for the task at hand.

A method to quantify hand-transmitted vibration exposure based on the biodynamic stress concept.

This study generally hypothesized that the vibration-induced biodynamic stress and number of its cycles in a substructure of the hand-arm system play an important role in the development of vibration-induced disorders in the substructure. As the first step to test this hypothesis, the specific aims of this study were to develop a practical method to quantify the biodynamic stress-cycle measure, to compare it with ISO-weighted and unweighted accelerations, and to assess its potential for applications. A mechanical-equivalent model of the system was established using reported experimental data. The model was used to estimate the average stresses in the fingers and palm. The frequency weightings of the stresses in these substructures were derived using the proposed stress-cycle measure. This study found the frequency dependence of the average stress distributed in the fingers is different from that in the palm. Therefore, this study predicted that the frequency dependencies of finger disorders could also be different from those of the disorders in the palm, wrist, and arms. If vibration-induced white finger (VWF) is correlated better with unweighted acceleration than with ISO-weighted acceleration, the biodynamic stress distributed in the fingers is likely to play a more important role in the development of VWF than is th e biodynamic stressdistributed in the other substructures of the hand-arm system. The results of this study also suggest that the ISO weighting underestimates the high-frequency effect on the finger disorder development but it may provide a reasonable risk assessment of the disorders in the wrist and arm.

Analysis of the point mechanical impedance of fingerpad in vibration.

Biodynamic responses of the finger-hand-arm system, such as apparent mass and mechanical impedance, characterize the relationship between the motion of the finger-hand-arm system and the dynamic force acting on the driving point, and they are useful for vibration exposure assessment. In the present study, a two-dimensional finite element (FE) model has been proposed to simulate the biodynamic responses of the fingerpad in vibration tests. The fingernail was supported by the rigid ground while the fingerpad was activated by a vibration probe. The fingertip model is composed of skin, subcutaneous tissue, bone, and nail. The soft tissues (i.e., skin and subcutaneous tissues) were assumed to be non-linearly elastic and linearly viscoelastic. The FE model was applied to predict the effects of pre-indentation of the vibration probe onto the fingerpad, the damping of the soft tissues, and probe mass on the magnitude and phase angle of the mechanical impedance and the apparent mass, as measured in the vibration tests. The model predictions showed that the probe mass has non-negligible effects on the measured biodynamic responses in the vibration tests. In order to determine "true" biodynamic responses of the finger-hand-arm system, the mass effects have to be cancelled using an appropriate approach. The present analysis provided a theoretical explanation, from a biomechanical point-of-view, for the inconsistencies in the published experimental data for the biodynamic responses of fingerpad.

Analysis of the dynamic strains in a fingertip exposed to vibrations: Correlation to the mechanical stimuli on mechanoreceptors.

The reduction in vibrotactile sensitivity in the fingertip is assumed to be associated with the exposure of the tissues to repetitive, non-physiological strains during dynamic loading. Experimental results demonstrated that the magnitude of a vibration-induced temporary threshold shift is dependent upon the vibration frequency of both the exposure and testing stimuli. In the present study, the frequency-dependent strain imposed on cutaneous and subcutaneous tissues of the fingertip is analyzed theoretically using a finite element model. The proposed fingertip model is two-dimensional and includes major anatomical substructures: skin, subcutaneous tissue, bone, and nail. The soft tissues (skin and subcutaneous tissues) were assumed to be nonlinearly elastic and viscoelastic, while the bone and nail were considered as linearly elastic. Simulations were performed for the contact between the fingertip and a flat surface for four different pre-compressions (0.5, 1.0, 1.5, and 2.0 mm). The frequency-dependent distributions of the dynamic strain magnitudes in the soft tissues were investigated. The model predictions indicated that the vibration exposure at a frequency range from 63 to 250 Hz will induce excessive dynamic strain in the deep zone of the finger tissues, effectively inhibiting the high-frequency mechanoreceptors; while the vibration exposure at low frequency (less than 31.5 Hz) tends to induce excessive dynamic strain in superficial layer in the tissues, inhibiting the low-frequency mechanoreceptors. These theoretical predictions are consistent with the experimental observations in literature. The proposed model can be used to predict the responses of the soft tissues in different depths to vibration exposures, providing valuable information and data that are essential for improving vibrotactile perception tests.

Acute vibration increases alpha2C-adrenergic smooth muscle constriction and alters thermosensitivity of cutaneous arteries.

The vascular symptoms of hand-arm vibration syndrome, including cold-induced vasospasm, are in part mediated by increased sensitivity of cutaneous arteries to sympathetic stimulation. The goal of the present study was to use a rat tail model to analyze the effects of vibration on vascular function and alpha-adrenoceptor (AR) responsiveness. Rats were exposed to a single period of vibration (4 h, 125 Hz, constant acceleration 49 m/s2 root mean square). The physical or biodynamic response of the tail demonstrated increased transmissibility or resonance at this frequency, similar to that observed during vibration of human fingers. Morphological analysis demonstrated that vibration did not appear to cause structural injury to vascular cells. In vitro analysis of vascular function demonstrated that constriction to the alpha1-AR agonist phenylephrine was similar in vibrated and control arteries. In contrast, constriction to the alpha2-AR agonist UK14304 was increased in vibrated compared with control arteries, both in endothelium-containing or endothelium-denuded arteries. The alpha2C-AR antagonist MK912 (3 x 10(-10) M) inhibited constriction to UK14304 in vibrated but not control arteries, reversing the vibration-induced increase in alpha2-AR activity. Moderate cooling (to 28 degrees C) increased constriction to the alpha2-AR agonist in control and vibrated arteries, but the magnitude of the amplification was less in vibrated compared with control arteries. Endothelium-dependent relaxation to acetylcholine was similar in control and vibrated arteries. Based on these results, we conclude that a single exposure to vibration caused a persistent increase in alpha2C-AR-mediated vasoconstriction, which may contribute to the pathogenesis of vibration-induced vascular disease.

Distribution of mechanical impedance at the fingers and the palm of the human hand.

A comprehensive understanding of the complex biodynamic response of the human fingers-hand-arm system may help researchers determine the causation of injuries arising from hand-transmitted vibration. This study theoretically demonstrates that the mechanical impedance (MI) in a hand power grip, as a measure of the biodynamic response of the system, can be divided into finger MI and palm MI. A methodology is developed to measure them separately and to investigate their distribution characteristics. This study involves 6 adult male subjects, constant-velocity sinusoidal excitations at 10 different discrete frequencies (16, 25, 40, 63, 100, 160, 250, 400, 630, 1000 Hz), and three different hand-handle coupling conditions. Our results suggest that at low frequencies (40 Hz), the palm MI is substantially higher than the finger MI; the majority of the hand MI remains distributed at the palm up to 100 Hz; and at frequencies higher than 160 Hz, the finger MI is comparable to or higher than the palm MI. Furthermore, at frequencies equal to or above 100 Hz, the finger MI is practically independent of the palm-handle coupling conditions. Knowledge of the MI distribution pattern may increase the understanding of vibration transmission to the hand and aid in the development of effective isolation devices.

Biodynamic response of human fingers in a power grip subjected to a random vibration.

BACKGROUND: Knowledge of the biodynamic response (BR) of the human hand-arm system is an important part of the foundation for the measurement and assessment of hand-transmitted vibration exposure. This study investigated the BR of human fingers in a power grip subjected to a random vibration. METHOD: Ten male subjects were used in the experiment. Each subject applied three coupling actions to a simulated tool handle at three different finger grip force levels. RESULTS AND CONCLUSIONS: The BR is practically independent of the hand coupling actions for frequencies at or above 100 Hz. Above 50 Hz, the BR is correlated to finger and hand sizes. Increasing the finger coupling force significantly increases the BR. Therefore, hand forces should be measured and used when assessing hand-transmitted vibration exposure. The results also show that under a constant-velocity vibration, the finger vibration power absorption at frequencies above 200 Hz is approximately twice that at frequencies below 100 Hz. This suggests that the frequency weighting specified in the current ISO 5349-1 (2001) may underestimate the high frequency effect on vibration-induced finger disorders.

Vibration energy absorption (VEA) in human fingers-hand-arm system.

A methodology for measuring the vibration energy absorbed into the fingers and the palm exposed to vibration is proposed to study the distribution of the vibration energy absorption (VEA) in the fingers-hand-arm system and to explore its potential association with vibration-induced white finger (VWF). The study involved 12 adult male subjects, constant-velocity sinusoidal excitations at 10 different discrete frequencies in the range of 16-1000 Hz, and four different hand-handle coupling conditions (finger pull-only, hand grip-only, palm push-only, and combined grip and push). The results of the study suggest that the VEA into the fingers is considerably less than that into the palm at low frequencies (< or = 25 Hz). They are, however, comparable under the excitations in the 250-1000 Hz frequency range. The finger VEA at high frequencies (> or = 100 Hz) is practically independent of the hand-handle coupling condition. The coupling conditions affect the VEA into the fingers and the palm very differently. The finger VEA results suggest that the ISO standardized frequency weighting (ISO 5349-1, 2001) may underestimate the effect of high frequency vibration on vibration-induced finger disorders. The proposed method may provide new opportunities to examine VEA and its association with VWF and other types of vibration-induced disorders in the hand-arm system.

An evaluation of the standardized chipping hammer test specified in ISO 8662-2.

OBJECTIVES: Prolonged exposure to severe chipping hammer vibration may cause hand-arm vibration syndrome. A reliable test method is required to select appropriate tools and assist in the development of better chipping hammers. In the present study, the ISO standardized test method (ISO 8662-2, 1992) was examined through an investigation of the vibration characteristics of chipping hammers operating on the energy absorber specified in the standard. METHODS: The energy absorber and test setup were designed and constructed based on those specified in the standard. The experiment employed six subjects and used two pneumatic chipping hammers and three different feed forces (50, 100 and 200 N). The subject posture was the same as that specified in the standard. RESULTS: The vibration emission at the tool dominant frequency (or air blow rate) generally declined with an increase in feed force, thus decreasing the frequency-weighted accelerations. The increase in feed force, however, resulted in an increase in the unweighted vibration emission at high frequencies. The chipping hammer vibration emission operating on the energy absorber at the high feed force (200 N) was inconsistent. CONCLUSIONS: The measurement method has a good repeatability except at a high feed force. The feed force has a significant effect on the vibration emission. The single feed force specified in the standard may not be sufficient to test the tool behaviors. Multiple levels of feed force should be used for the chipping hammer test. Doing so may provide a more appropriate basis for tool screening.

A method for reducing adaptor misalignment when testing gloves using ISO 10819.

OBJECTIVES: International standard ISO 10819 was established in order to quantify the vibration attenuation characteristics of anti-vibration gloves. One problem that exists with the standard is possible misalignment of the palm adaptor that is placed underneath the test glove. If the adaptor becomes misaligned, the measured glove transmissibility will be lower than the actual value. A tri-axial accelerometer was installed in the adaptor and was used as the basis for providing visual feedback of the adaptor alignment to the test subjects. The objective of this study was to test the hypothesis that adaptor misalignment could be reduced by providing feedback to the test subjects. METHODS: Eight male volunteers (mean age 24.8 yr) were used in the study. Each subject performed two sets of tests: the standard ISO 10819 glove test and the modified version. Three different anti-vibration gloves were tested. Glove transmissibility and adaptor misalignment were calculated for each glove. A three-way analysis of variance was used to analyze the results. RESULTS: A comparison of the two testing methods showed that the modified glove testing method did reduce misalignment significantly, which, in turn, resulted in an increase in the measured glove transmissibility. CONCLUSIONS: The proposed method greatly improved the standard deviation of transmissibility and made the test results more consistent.