A feasibility study to investigate the utility of a home-based exercise intervention during and after neo-adjuvant chemotherapy for oesophago-gastric cancer-the ChemoFit study protocol.

BACKGROUND: Treatment of locally advanced oesophago-gastric adenocarcinoma usually entails neo-adjuvant chemotherapy (NAC) and surgery. Surgery is associated with high morbidity and mortality. Cardiopulmonary reserve of patients having major surgery is related to postoperative outcomes. Complications are associated with poorer quality of life and may affect prognosis. Preventing complications may be beneficial to both of these and have cost implications. Prehabilitation may improve recovery from surgery by increasing a patients' fitness before surgery. Designing a potentially cost and resource effective regimen which improves cardiopulmonary reserve may have a beneficial impact on patient outcomes after surgery. METHODS: The ChemoFit study is a non-randomised, single-arm and single-centre pilot study designed to investigate the feasibility of a home-based prehabilitation exercise intervention for patients receiving neoadjuvant treatment prior to oesophago-gastric surgery. Forty patients will be recruited at a single high-volume centre. The simple, home-based exercise intervention involves patients increasing their daily step-count during and after NAC and in the weeks leading up to surgical resection of the cancer. Additionally, quality of life assessments (QLQ-C30 and QLQ-OG25), oncological treatment delivery and participant perceptions of the study assessed by focus groups and questionnaires will be performed. The primary outcomes are to assess feasibility of the exercise intervention. The secondary outcomes will evaluate changes in cardiopulmonary reserve, sarcopenia and fat composition. DISCUSSION: It is anticipated that during an important teachable moment, the diagnosis and treatment of cancer, our patients will be open to the possibility of improving their fitness during chemotherapy and before major cancer surgery. It is possible that the negative impact of NAC on cardiopulmonary fitness could be prevented by implementing a home-based prehabilitation programme during and after NAC, prior to surgery for oesophago-gastric adenocarcinoma. TRIAL REGISTRATION: This study has been approved by the Health Research Authority (REC 18/WA/0427). Newcastle upon Tyne Hospitals NHS Foundation Trust (NUTH) will act as the study sponsor and the work is funded by a grant awarded by The Jon Moulton Charitable Foundation, supported by a research post funded by the Sir Bobby Robson Foundation. Trial registration: Clinicaltrials.gov, NCT04194463. Registered 11th December 2019-retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT04194463.

Structural geology data and 3-D subsurface models of the Budgell Harbour Stock and associated dykes, Newfoundland, Canada.

The data presented in this article are primarily related to the Tectonophysics research article "Rift-related magmatism on magma-poor margins: Structural and potential field analyses of the Mesozoic Notre Dame Bay intrusions, Newfoundland, Canada and their link to North Atlantic Opening" Peace et al. (2018). The present data article contains structural geology data from lamprophyre dykes and surrounding country rock in proximity to the Mesozoic gabbroic Budgell Harbour Stock (BHS), Newfoundland, Canada, in addition to sub-surface density and susceptibility models of the main igneous body. The structural geology data include: dyke locations, orientations, thickness and marginal lineations, in addition to country rock bedding and kinematic data from nearby faults. The 3-D sub-surface density and susceptibility models were derived from the inversion of magnetic and full tensor gradiometry (FTG) data, respectively, using a probabilistic approach to inversion described in the Society of Exploration Geophysicists (SEG) 2018 Technical Program Expanded Abstract "3-D inversion of airborne gravity gradiometry data for the Budgell Harbour Stock: A case history of using a probabilistic approach" Geng et al. (2018).

An esthetic technique for veneering anterior stainless steel crowns with composite resin.

The restoration of primary anterior teeth presents complicated esthetic and retention problems to the clinician. A technique is described for the chairside veneering of composite resin to stainless steel crowns, which results in well contoured restorations with superior durability and esthetics. A trimmed and fitted stainless steel crown can be veneered in three to five minutes. This provides the adaptability and gingival contour benefits of the stainless steel crown in conjunction with the cosmetics of the composite facings. The technique described produced composite veneers with a mean sheer bond strength of 3520 PSI (24.4 Mpa).

An epidemiologic study of factors affecting extrinsic staining of teeth in an English population.

A survey is described in which extrinsic staining of teeth was assessed by practising dentists during routine clinical examinations. Habits information was also supplied by patients. The results show that extrinsic staining is markedly influenced by smoking habits and age, and that males tend to have more staining than females. The effect of tea and coffee consumption was not pronounced. No effect attributable to the use of a stannous fluoride toothpaste was observed.