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Cephalalgia ; 31(13): 1359-67, 2011 Oct.
Article in English | MEDLINE | ID: mdl-21914734

ABSTRACT

OBJECTIVE: To assess validity of a self-administered web-based migraine-questionnaire in diagnosing migraine aura for the use of epidemiological and genetic studies. METHODS: Self-reported migraineurs enrolled via the LUMINA website and completed a web-based questionnaire on headache and aura symptoms, after fulfilling screening criteria. Diagnoses were calculated using an algorithm based on the International Classification of Headache Disorders (ICHD-2), and semi-structured telephone-interviews were performed for final diagnoses. Logistic regression generated a prediction rule for aura. Algorithm-based diagnoses and predicted diagnoses were subsequently compared to the interview-derived diagnoses. RESULTS: In 1 year, we recruited 2397 migraineurs, of which 1067 were included in the validation. A seven-question subset provided higher sensitivity (86% vs. 45%), slightly lower specificity (75% vs. 95%), and similar positive predictive value (86% vs. 88%) in assessing aura when comparing with the ICHD-2-based algorithm. CONCLUSIONS: This questionnaire is accurate and reliable in diagnosing migraine aura among self-reported migraineurs and enables detection of more aura cases with low false-positive rate.


Subject(s)
Internet , Migraine with Aura/diagnosis , Patient Selection , Surveys and Questionnaires , Adolescent , Adult , Aged , Algorithms , Area Under Curve , Cohort Studies , Female , Humans , International Classification of Diseases , Interviews as Topic , Male , Middle Aged , Models, Theoretical , Netherlands , Predictive Value of Tests , ROC Curve , Reproducibility of Results , Sampling Studies , Self Report , Young Adult
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