Early results of synchronous carotid endarterectomy and off-pump coronary revascularization.

AIM: This study reports results of synchronous carotid endarterectomy (CEA) and off-pump coronary artery bypass grafting (CABG) in further support of the hypothesis that carotid and coronary artery revascularization can be safely performed in most patients. METHODS: The series includes 74 consecutive patients underwent synchronous CEA and off-pump CABG (group A) compared with 50 patients undergoing synchronous CEA and on-pump CABG (group B). Primary endpoint of this study are death, stroke, perioperative myocardial infarction and need for repeated revascularization within 30 days of the procedures. The secondary endpoint includes local and systemic complications. RESULTS: No stroke was observed in group A. Ipsilateral minor stroke occurred in two patients of group B (4%). Two deaths within 30 days were observed in group A (2.7%) compared with 4 deaths in group B (8%). Combined stroke/death rate at 30 days was 2.7% in group A compared with 12% in group B (P< 0.05). No significant differences in myocardial infarction, local and systemic complications were observed. CONCLUSION: Synchronous CEA and off-pump CABG may reduce the high surgical risk of patients who actually require combined carotid and coronary revascularization. This opinion has to be substantiated by larger studies and randomized trial.

Evaluation of prosthetic-valved devices by means of numerical simulations.

The in vivo evaluation of prosthetic device performance is often difficult, if not impossible. In particular, in order to deal with potential problems such as thrombosis, haemolysis, etc., which could arise when a patient undergoes heart valve replacement, a thorough understanding of the blood flow dynamics inside the devices interacting with natural or composite tissues is required. Numerical simulation, combining both computational fluid and structure dynamics, could provide detailed information on such complex problems. In this work, a numerical investigation of the mechanics of two composite aortic prostheses during a cardiac cycle is presented. The numerical tool presented is able to reproduce accurately the flow and structure dynamics of the prostheses. The analysis shows that the vortical structures forming inside the two different grafts do not influence the kinematics of a bileaflet valve or the main coronary flow, whereas major differences are present for the stress status near the suture line of the coronaries to the prostheses. The results are in agreement with in vitro and in vivo observations found in literature.