Will the real resource theory please stand up! Vigilance is a renewable resource and should be modeled as such.

The vigilance decrement or decline in signal detection performance with time on task is one of the most reliable findings in the cognitive neuroscience and psychology literatures. The majority of theories proposed to explain the decrement are limited cognitive or attention resource based theories; the central nervous system is a limited capacity processor. The decrement in performance is then due to resource reallocation (or misallocation), resource depletion or some combination of both mechanisms. The role of resource depletion, in particular, is hotly debated. However, this may be due to a lack of understanding of the renewable nature of the vigilance resources and how this renewal process impacts performance during vigilance tasks. In the present paper, a simple quantitative model of vigilance resource depletion and renewal is described and shown to generate performance data similar to results seen in both humans and spiders. This model clarifies the role resource depletion and resource renewal may play in vigilance in both people and other animals.

The Role of Anti-Racist Community-Partnered Praxis in Implementing Restorative Circles Within Marginalized Communities in Southern California During the COVID-19 Pandemic.

The COVID-19 pandemic has exacerbated the adverse influence of structural racism and discrimination experienced by historically marginalized communities (e.g., Black, Latino/a/x, Indigenous, and transgender people). Structural racism contributes to trauma-induced health behaviors, increasing exposure to COVID-19 and restricting access to testing and vaccination. This intersection of multiple disadvantages has a negative impact on the mental health of these communities, and interventions addressing collective healing are needed in general and in the context of the COVID-19 pandemic. The Share, Trust, Organize, and Partner COVID-19 California Alliance (STOP COVID-19 CA), a statewide collaborative of 11 universities and 75 community partners, includes several workgroups to address gaps in COVID-19 information, vaccine trial participation, and access. One of these workgroups, the Vaccine Hesitancy Workgroup, adopted an anti-racist community-partnered praxis to implement restorative circles in historically marginalized communities to facilitate collective healing due to structural racism and the COVID-19 pandemic. The project resulted in the development of a multilevel pre-intervention restorative process to build or strengthen community-institutional partnerships when procurement of funds has been sought prior to community partnership. This article discusses this workgroup's role in advancing health justice by providing a community-based mental health intervention to marginalized communities in Southern California while using an antiracist praxis tool to develop a successful community-institutional partnership and to live up to the vision of community-based participatory research.

A wrist-inspired suspended tubercle-type tensegrity joint with variable stiffness capacity.

In complex and unpredictable environments or in situations of human-robot interaction, a soft and flexible robot performs more safely and is more impact resistant compared to a traditional rigid robot. To enable robots to have bionic features (flexibility, compliance and variable stiffness) similar to human joints, structures involving suspended tubercle tensegrity are researched. The suspended tubercle gives the joint compliance and flexibility by isolating two moving parts. The variable stiffness capacity is achieved by changing the internal stress of tensegrity through the simultaneous contraction or relaxation of the driving tendons. A wrist-inspired tensegrity-based bionic joint is proposed as a case study. It has variable stiffness and two rotations with a total of three degrees of freedom. Through theoretical derivation and simulation calculation in the NASA Tensegrity RobotToolkit (NTRT) simulator, the range of motion, stiffness adjustable capacity, and their interaction are studied. A prototype is built and tested under a motion capture system. The experimental result agrees well with the theoretical simulation. Our experiments show that the suspended tubercle-type tensegrity is flexible, the stiffness is adjustable and easy to control, and it has great potential for bionic joints.

SFA-MDEN: Semantic-Feature-Aided Monocular Depth Estimation Network Using Dual Branches.

Monocular depth estimation based on unsupervised learning has attracted great attention due to the rising demand for lightweight monocular vision sensors. Inspired by multi-task learning, semantic information has been used to improve the monocular depth estimation models. However, multi-task learning is still limited by multi-type annotations. As far as we know, there are scarcely any large public datasets that provide all the necessary information. Therefore, we propose a novel network architecture Semantic-Feature-Aided Monocular Depth Estimation Network (SFA-MDEN) to extract multi-resolution depth features and semantic features, which are merged and fed into the decoder, with the goal of predicting depth with the support of semantics. Instead of using loss functions to relate the semantics and depth, the fusion of feature maps for semantics and depth is employed to predict the monocular depth. Therefore, two accessible datasets with similar topics for depth estimation and semantic segmentation can meet the requirements of SFA-MDEN for training sets. We explored the performance of the proposed SFA-MDEN with experiments on different datasets, including KITTI, Make3D, and our own dataset BHDE-v1. The experimental results demonstrate that SFA-MDEN achieves competitive accuracy and generalization capacity compared to state-of-the-art methods.

The discovery of orally active triaminotriazine aniline amides as inhibitors of p38 MAP kinase.

A new structural class of triaminotriazine aniline amides possessing potent p38 enzyme activity has been discovered. The initial hit (compound 1a) was identified through screening the Pharmacopeia ECLiPS compound collection. SAR modification led to the identification of a short acting triaminotriazine aniline methoxyamide (compound 1m) possessing in vitro and in vivo oral activity in animal models of acute and chronic inflammatory disease. An X-ray crystal structure of compound 1m in this class, cocrystallized with unactivated p38 alpha protein, indicates that these compounds bind to the ATP binding pocket and possess key H-bonding interactions within a deeper cleft. Hydrogen bonding between one of the triazine nitrogens and the backbone NH of the Met109 residue occurs through a water molecule. The methoxyamide NH and carbonyl oxygen are within H-bonding distance of Glu71 and Asp168.