Microglial Galectin3 enhances endothelial metabolism and promotes pathological angiogenesis via Notch inhibition by competitively binding to Jag1.

Microglia were considered as immune cells in inflammation until their angiogenic role was widely understood. Although the pro-inflammatory role of microglia in retinal angiogenesis has been explored, little is known about its role in pro-angiogenesis and the microglia-endothelia interaction. Here, we report that galectin-3 (Gal3) released by activated microglia functions as a communicator between microglia and endothelia and competitively binds to Jag1, thus inhibiting the Notch signaling pathway and enhancing endothelial angiogenic metabolism to promote angiogenesis. These results suggest that Gal3 may be a novel and effective target in the treatment of retinal angiogenesis.

The Significance of the Ocular Adverse Effect Induced by Systemic Taxane Application.

In recent years, in-depth research on anti-tumor therapy has brought the emergence of new active chemotherapeutic agents and combination regimens. However, as one of them, taxane drugs are widely used in clinical practice, but it should be noted that many side reactions caused by their application bring some difficulties to routine management. Among the side reactions related to taxane anti-tumor therapy, ocular adverse reactions are occasionally reported and are not life-threatening but may seriously affect patients' life quality. Thus, the continuation, reduction and cessation of taxane chemotherapy still need to be further evaluated by ophthalmologists and oncologists once the side effects show up. To prevent ocular side reactions, close attention should be paid to complications during medication. To facilitate the oncology department and ophthalmologists to comprehensively understand the ophthalmic adverse reactions of taxane drugs and their possible mechanisms and improve drug use efficiency, we collected relevant literature and reviewed and provided some suggestions for the monitoring and managing of ophthalmic toxicity.

Factors Related with Willingness to Participate in Pharmacological Clinical Trials of Patients with Chronic Diseases: Investigation of Medical Ethics / 中国康复理论与实践

Objective:To investigate the medical ethics and willingness to participate in pharmacological clinical trials of patients with chronic diseases, and explore the related factors. Methods:In December, 2020, 318 patients with chronic diseases from the Department of Internal Medicine, Beijing Bo'ai Hospital were investigated with a self-made medical ethics questionnaire for the items of medical ethics and willingness to participate in pharmacological clinical trials. Results:The attention to medical knowledge, awareness of their rights and responsibilities were various with the courses of disease, educational levels and resident areas. The satisfaction for treatment and trust to the doctors were related with the willingness to participate in pharmacological clinical trials by multivariate Logistic regression (P < 0.05). The patients in trials paid the most attention to the safety of the trail, and then the therapeutic effect. Conclusion:Promoting and protecting the medical rights, improving the trust to doctors, strengthening the publicity of clinical trial knowledge, may promote the willingness to participate in pharmacological clinical trials of patients with chronic diseases.

Obesity and Dietary Nutrition in Stroke Patients during Rehabilitation / 中国康复理论与实践

Objective:To observe the condition of obesity and dietary nutrition for stroke patients accepting rehabilitation. Methods:From November, 2015 to June, 2018, 115 inpatients were investigated their height, body mass, somatotype and dietary. They were divided into 18-49 year-old group (n = 41), 50-64 year-old group (n = 54) and ≥ 65 year-old group (n = 20). Results:The ratio of overweight/obesity and abdominal obesity were high in all the groups. There were significant differences in the overweight/obesity ratio among the three groups (χ2 = 6.978, P < 0.05), but not in abdominal obesity ratio (χ2 = 3.290, P > 0.05). Their intake of energy, carbohydrate, vitamin B1, vitamin B2, vitamin E, calcium, potassium, magnesium and selenium in all the groups was less than the recommendation (t > 2.548, P < 0.05), while the intake of cholesterol, iron, phosphorus and copper was more (t > 2.476, P < 0.05). The intake of protein and fat was more than the recommendation in the 18-49 year-old and the 50-64 year-old groups (t > 2.041, P < 0.05), and the intake of niacin was more than the recommendation in the 18-49 year-old group (t = 2.239, P < 0.05). Conclusion:For stroke inpatients accepting rehabilitation, it is necessary to supply dietary with suitable energy, enough carbohydrate, less fat, and sufficient protein, calcium, iron, vitamin A, vitamin B1, vitamin B2 and dietary fiber in the diet.

Obesity and Dietary Nutrition in Stroke Patients during Rehabilitation / 中国康复理论与实践

Objective:To observe the condition of obesity and dietary nutrition for stroke patients accepting rehabilitation. Methods:From November, 2015 to June, 2018, 115 inpatients were investigated their height, body mass, somatotype and dietary. They were divided into 18-49 year-old group (n = 41), 50-64 year-old group (n = 54) and ≥ 65 year-old group (n = 20). Results:The ratio of overweight/obesity and abdominal obesity were high in all the groups. There were significant differences in the overweight/obesity ratio among the three groups (χ2 = 6.978, P < 0.05), but not in abdominal obesity ratio (χ2 = 3.290, P > 0.05). Their intake of energy, carbohydrate, vitamin B1, vitamin B2, vitamin E, calcium, potassium, magnesium and selenium in all the groups was less than the recommendation (t > 2.548, P < 0.05), while the intake of cholesterol, iron, phosphorus and copper was more (t > 2.476, P < 0.05). The intake of protein and fat was more than the recommendation in the 18-49 year-old and the 50-64 year-old groups (t > 2.041, P < 0.05), and the intake of niacin was more than the recommendation in the 18-49 year-old group (t = 2.239, P < 0.05). Conclusion:For stroke inpatients accepting rehabilitation, it is necessary to supply dietary with suitable energy, enough carbohydrate, less fat, and sufficient protein, calcium, iron, vitamin A, vitamin B1, vitamin B2 and dietary fiber in the diet.

Correlation between Body Composition and Dietary Nutrition for Stroke Patients during Rehabilitation / 中国康复理论与实践

Objective:To investigate the body composition and the nutrition of diet of the stroke inpatients during rehabilitation. Methods:From November, 2015 to December, 2018, 100 stroke inpatients were sequentially recruited and measured the body composition, and the diets were investigated. The correlations among their body composition, dietary nutrition and rehabilitation time were analyzed. Results:The skeletal muscle mass was less than the target quantity (t = -2.605, P < 0.05), the percentage of skeletal muscle of upper limbs was less in the affected side than in the unaffected side (t = -1.984, P < 0.05). The body mass, body mass index, body fat percentage and abdominal obesity were all significantly higher than the target quantity (t > 10.715, P < 0.001). The daily intake of energy, carbohydrates, vitamin B1, vitamin B2, vitamin E, calcium, potassium, zinc, magnesium and selenium were lower than the recommendation (|t| > 4.427, P < 0.05), but the daily intake of protein, fat, cholesterol, niacin, iron, phosphorus and copper were higher (t > 2.122, P < 0.05). There were correlation between body composition index and dietary protein, fat and rehabilitation time (P < 0.05). Conclusion:It is necessary to reduce the fat intake and promote sufficient intake of carbohydrate, protein and so on, in nutritional intervention plans for hospitalized stroke rehabilitation patients.

Differences in effects of Zuojin Pills and its similar formulas on Wei cold model in rats / 中国结合医学杂志

<p><b>OBJECTIVE</b>To explore the effects of Zuojin Pills and its similar formulas on the stomach cold syndrome in a Wei cold model in rats.</p><p><b>METHODS</b>The rat Wei cold model was established by intragastric administration of glacial NaOH, and the gastric mucosa injury indices, together with the levels of motilin and gastrin in the stomach, were determined. The preventive and curative effects of Zuojin Pills and its similar formulas on gastric mucosa injury were investigated.</p><p><b>RESULTS</b>Zuojin Pills and its similar formulas could protect the gastric mucosa in the gastric cold model in rats at different levels. Fanzuojin Pills had the best effect in inhibiting gastric mucosa injury.</p><p><b>CONCLUSION</b>The different pharmacological effects of Zuojin Pills and its similar formulas in the rat gastric cold model were partially correlated with the degrees in cold and heat properties of the formulas.</p>