ABSTRACT
AIM: The role of octamer-binding transcription factor 4 (Oct4) in gastric cancer (GC) progression is still under debate and reported results are inconsistent. Therefore, we conducted a meta-analysis to evaluate the clinicopathological and prognostic significance of Oct4 expression in patients with GC. MATERIALS & METHODS: Relevant articles were retrieved from a diverse number of databases, and meta-analysis was completed using STATA software 12.0. RESULTS: Total of 21 studies were included in this analysis (3209 samples). Expression of Oct4 was associated with incidence, tumor size, lymph node metastasis, histological differentiation, pTNM stage, tumor depth of infiltration, vascular invasion and distal metastasis. Additionally, Oct4 expression was correlated with poor overall survival rate. CONCLUSION: The Oct4 overexpression suggested aggressive biological behaviors and imply that Oct4 may be a useful prognostic biomarker in gastric cancers.
Subject(s)
Biomarkers, Tumor/metabolism , Octamer Transcription Factor-3/metabolism , Stomach Neoplasms/pathology , Humans , Neoplasm Invasiveness , Neoplasm Metastasis , Prognosis , Stomach Neoplasms/metabolismABSTRACT
AIM: The purpose of this study was to evaluate the impact of ß-catenin immunohistochemical expression on the prognostic of ovarian cancer (OC) for that ß-catenin could be responsible for the development and progress of OC. METHODS: We searched various databases to identify eligible studies, and Review Managers 5.2 software was fulfilled in the meta-analysis. RESULTS: A total of 11 studies were defined and composed in 1858 cases. ß-catenin expression was significantly correlated with poor overall survival (OS) in OC patients (HR: 2.48, 95% CI: 1.38-4.47, Pâ¯=â¯0.003), and showed a significant degree of heterogeneity (I2â¯=â¯83%, Pâ¯<â¯0.00001). Subgroup analysis indicated that accumulation in the nucleus and/or cytoplasm, rather than membrane, considerably influences the survival of OC patients independently. CONCLUSION: Nucleus and/or cytoplasma of ß-catenin expression might be associated with tumor progression and could be a possible potential predictive factor of poor prognosis in OC patients.
Subject(s)
Ovarian Neoplasms/metabolism , Ovarian Neoplasms/pathology , Up-Regulation , beta Catenin/metabolism , Biomarkers, Tumor/metabolism , Cell Nucleus/metabolism , Cytoplasm/metabolism , Disease Progression , Female , Gene Expression Regulation, Neoplastic , Humans , Neoplasm Staging , Prognosis , Survival AnalysisABSTRACT
AIM: Notch1 expression remains controversial on digestive tract cancers. This meta-analysis was performed to assess the clinicopathological significance of Notch1 expression in individuals with digestive tract cancers, mainly involving esophageal squamous cell carcinoma (ESCC), gastric cancer (GC), pancreatic cancer (PC) and colorectal cancer (CRC). METHODS: Available articles were searched from the online databases, and the meta-analysis was done using Review Manager software 5.3. RESULTS: 35 studies were included in this analysis (6187 samples). Notch1 is downregulated in esophageal squamous cell carcinoma (p < 0.00001), Notch1 expression at high levels was detected in GC (p = 0.02) and CRC (p < 0.001), and no significant difference exists between PC and normal tissue (p = 0.76). CONCLUSION: Notch1 overexpression in GC and CRC suggested aggressive biological behaviors, and Notch1 may be a biomarker in digestive tract cancers.
