ABSTRACT
In response to no national standard for Gynostemma pentaphyllum, a market survey was carried out, and 17 batches of gypenosides extract and 29 batches of Gypenosides Tablets on the market were collected. With gypenoside A as an index, the TLC qualitative identification and HPLC quantitative evaluation method of gypenosides extract and tablets was established. Based on the determination results of 17 batches of gypenosides extract and 29 batches of Gypenosides Tablets, the quality standards of gypenosides extract and tablets were formulated respectively, so as to give suggestions for improving the quality standards of gypenosides extract and tablets. Compared with the existing ministerial standards, the qualitative identification and quantitative detection of specific components were added, in order to provide scientific basis and suggestions for the revision of the quality standard of gypenosides extract and tablet preparation.
Subject(s)
Gynostemma , Plant Extracts , Reference Standards , TabletsABSTRACT
OBJECTIVE: The aim of this study was to investigate the mechanisms of C. minima in the treatment of allergic rhinitis. METHOD: An allergic rhinitis animal model induced by ragweed pollen was established. After treatment with an active extract of C. minima, histopathological changes in the nasal mucosa of guinea pig were observed by transmission electron microscope. RESULT: In the allergeic rhinitis model group, there appear a large number of lysosomes in the nasal epithelium with organelles vacuolated and nucleus deformed. Cells in the proper lamina of connective tissue were disarranged with organelles damaged, and there was also infiltration of eosinophils and mast cells in the connective tissue. However, in the treatment group receiving C. minima extract, the pathological changes mentioned above were significantly decreased. CONCLUSION: C. minima is effective in treating allergic rhinitis.
