ABSTRACT
This paper reports on seven atypical Philadelphia chromosome translocations in chronic myelocytic leukemia. Three of them, a t(16;22), t(17;22), and t(9;14;22) have already been observed before, while the t(X;9;11;22), t(X;22), t(3;22) and t(3;4;9;22) are newly reported.
Subject(s)
Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics , Philadelphia Chromosome , Translocation, Genetic , Adult , Female , Humans , Karyotyping , Male , Middle Aged , X ChromosomeABSTRACT
Clonal chromosomal evolution was observed in a 16-year-old boy suffering from Ph1-positive CML. An isodicentric Ph1 chromosome appeared 20 weeks after the initial diagnosis. At that time an allogeneic bone marrow transplantation was performed. Thereafter, during an observation period of more than 13 months, chromosome analyses showed neither the Ph1 chromosome nor the abnormal isodicentric variant. Close cytogenetic monitoring is suggested to reveal early unfavorable prognostic signs of the onset of blast crisis before it becomes evident in the bone marrow morphology.
Subject(s)
Bone Marrow Transplantation , Cell Transformation, Neoplastic , Chromosomes, Human, 21-22 and Y , Leukemia, Myeloid/genetics , Adolescent , Humans , Karyotyping , Leukemia, Myeloid/therapy , Male , PrognosisABSTRACT
In 48 patients with acute non-lymphoblastic leukemia, all of whom had been treated according to the protocol 7421 of the "acute leukemia group B", remission rates and survival times were correlated with the chromosome constitution of bone marrow cells at diagnosis. 45.8% of the patients had only normal metaphases (N-patients), 31.3% had normal and abnormal metaphases (AN-patients), and 22.9% had only abnormal metaphases (AA-patients). Chromosomal findings were unrelated to patients' age. The remission rate of the N-patients was 72.7%, of the AN-patients 60%, and of the AA-patients 36.4%. The respective median survival times were 12.5, 8.5 and 4.0 months. The difference in remission rates and survival times between patients with normal and without normal metaphases was significant. Once a remission had been obtained the prognosis was similar among the 3 groups. The better prognosis of the AA-patients in this study as compared to previous reports might be related to a more effective chemotherapy.
Subject(s)
Chromosomes, Human , Leukemia/diagnosis , Acute Disease , Adolescent , Adult , Age Factors , Aged , Female , Humans , Leukemia/drug therapy , Leukemia/genetics , Male , Metaphase , Middle Aged , Prognosis , Time FactorsABSTRACT
Two patients with extramedullary manifestation of the blastic phase of chronic myelocytic leukemia (CML) are reported. 100% of the metaphases derived from extranedullary sites were aneuploid. Despite the absence of blastic changes in the bone marrow and the peripheral blood, a significant proportion of the metaphases derived from these tissues also showed aneuploidy. It is suggested that maturation and differentiation of aneuploid myeloblasts are influenced by their environment.