ABSTRACT
Animal models have historically provided an appropriate benchmark for understanding human pathology, treatment, and healing, but few animals are known to naturally develop intervertebral disc degeneration. The study of degenerative disc disease and its treatment would greatly benefit from a more comprehensive, and comparable animal model. Alpacas have recently been presented as a potential large animal model of intervertebral disc degeneration due to similarities in spinal posture, disc size, biomechanical flexibility, and natural disc pathology. This research further investigated alpacas by determining the prevalence of intervertebral disc degeneration among an aging alpaca population. Twenty healthy female alpacas comprised two age subgroups (5 young: 2-6 years; and 15 older: 10+ years) and were rated according to the Pfirrmann-grade for degeneration of the cervical intervertebral discs. Incidence rates of degeneration showed strong correlations with age and spinal level: younger alpacas were nearly immune to developing disc degeneration, and in older animals, disc degeneration had an increased incidence rate and severity at lower cervical levels. Advanced disc degeneration was present in at least one of the cervical intervertebral discs of 47% of the older alpacas, and it was most common at the two lowest cervical intervertebral discs. The prevalence of intervertebral disc degeneration encourages further investigation and application of the lower cervical spine of alpacas and similar camelids as a large animal model of intervertebral disc degeneration.
Subject(s)
Cervical Vertebrae/pathology , Intervertebral Disc Degeneration/pathology , Intervertebral Disc/pathology , Magnetic Resonance Imaging , Animals , Biomechanical Phenomena , Camelids, New World , Disease Models, Animal , Female , Image Processing, Computer-Assisted , Intervertebral Disc Degeneration/diagnosis , Least-Squares AnalysisABSTRACT
Acute flank pain is a common problem in emergency medicine. The most frequent cause is urolithiasis, but many other entities can cause the same clinical presentation. In many institutions unenhanced computed tomography (CT) of the abdomen is used in this setting. One of the major advantages of unenhanced CT is its ability to detect other pathologies causing flank pain. In this pictorial review, we present the CT findings of pathologies other than stone disease in patients with acute flank pain.
