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INTRODUCTION: Psoriasis, an incurable chronic inflammatory disease, affects over 6 million people in China. Ixekizumab, a monoclonal antibody against interleukin-17A, has demonstrated efficacy and safety for the treatment of moderate-to-severe plaque psoriasis, although limited data are available regarding its use in routine clinical practice in China. We investigated the real-world application of ixekizumab in China. METHODS: Adults (≥ 18 years) with moderate-to-severe plaque psoriasis prescribed ixekizumab in routine clinical practice were enrolled in this prospective, observational, single-arm, multicenter, post-marketing surveillance study. The primary endpoint was the safety of ixekizumab at week 12. The effectiveness of ixekizumab, based on the Psoriasis Area and Severity Index (PASI) and Dermatology Life Quality Index (DLQI), was assessed as a secondary endpoint. RESULTS: In total, 666 patients were enrolled; 663 were included in the safety analysis, and 612 in the effectiveness analysis. At least one adverse event (AE) was reported by 42.7% (283/663) of patients, most of which were mild (242/283, 85.5%), and 32.7% (217/663) of patients reported AEs related to study treatment. The most frequently reported AEs were injection site reactions. AEs led to discontinuation in five patients (0.8%). Only three patients had a serious AE. Mean ± standard deviation (SD) change from baseline in PASI score was reduction in 10.79 ± 9.55 at week 2 and 16.80 ± 12.15 at week 12. At week 2, 63.7% of patients achieved PASI 50. At week 12, 93.2%, 77.4%, and 45.1% of patients achieved PASI 75, PASI 90, and PASI 100, respectively. Mean ± SD change from baseline in DLQI was reduction in 5.91 ± 6.27 at week 2 and 9.76 ± 7.16 at week 12. DLQI 0/1 was achieved by 19.8% and 59.9% of patients at week 2 and 12, respectively. CONCLUSION: Ixekizumab was well tolerated and effective in real-world clinical practice in Chinese adults with moderate-to-severe plaque psoriasis.
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East Asian People , Psoriasis , Humans , Adult , Prospective Studies , Treatment Outcome , Severity of Illness Index , Psoriasis/drug therapyABSTRACT
OBJECTIVE To compare the difference of octave band CE-Chirp ABR response threshold and behavioral auditory thresholds in children with hearing loss, and to explore the clinical value of octave band CE-Chirp ABR. METHODS Twenty-one children (40 ears) with hearing loss were selected. The octave band CE-Chirp ABR response threshold and behavioral auditory hearing threshold were measured in quiet environment. The results of two different test methods were compared. RESULTS The frequencies of octave band CE-Chirp ABR response thresholds and behavioral auditory thresholds were statistically analyzed. The correlation coefficients at different frequencies were 0.693, 0.830, 0.836 and 0.845, respectively, and the P values were ＜0.05. CONCLUSION There is good correlation between octave band CE-Chirp ABR response and behavioral auditory hearing measurement. Octave band CE-Chirp ABR, as an objective audiometry technique, has good stability and reliability for the objective response of hearing loss, and can better reflect the hearing level.
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Objective To study breathing characteristics of normal children of 6～7 years old when speaking in a normal manner.Methods RM 6240 physiological signal collection and processing system and Hx 100 respiratory transducer were used to collect the average peak expiratory pressure,inspiratory valley pressure,respiratory rate,respiratory depth from 160 normally speaking children.Results When speaking,the average peak expiratory pressure,inspiratory valley pressure,respiratory rate and respiratory depth of chest were all significantly increased (P<0.01);while that of abdomen was all reduced(P<0.05,P<0.01)except for respiratory rate(P<0.05)which was increased.In both respiratory conditions,all the data of abdomen were significantly larger than thaf of chest(P<0.01);all the data of boys were larger than that of girls(P<0.05,P<0.01).Conclusion When speaking,it involves thoraco-abdominal breathing,and the increase of chest activity will increase the volume of inhaled air.The increase of abdominal activity is for better control of respiratory airflow.Abdominal breathing plays a main role in normal speaking.Boys'respiratory muscles,respiratory organs are developed better than girls.
