1.
Eur J Cell Biol
; 89(1): 63-75, 2010 Jan.
Article
in English
| MEDLINE
| ID: mdl-20045214
ABSTRACT
In this review, we summarize results obtained using a conceptionally new chemical synthesis of NDP-sugars based on cycloSaligenyl (cycloSal) nucleotides as starting material (cycloSal technique). The cycloSal technique not only leads to stereoisomerically defined NDP-sugars in high yield, but the same principle provides very efficient routes towards nucleoside di- and -triphosphates. Moreover, sugar-nucleotides such as CMP-Neu5Ac and dinucleoside polyphosphates are available. Thus, the method offers a nearly universal chemical access towards a large number of highly interesting bioconjugates and biomolecules.
Subject(s)
Biochemistry/methods , Glycoconjugates/chemical synthesis , Nucleoside Diphosphate Sugars/chemical synthesis , Glycoconjugates/chemistry , Nucleoside Diphosphate Sugars/chemistry , Phosphorylation
2.
Angew Chem Int Ed Engl
; 47(8): 1500-2, 2008.
Article
in English
| MEDLINE
| ID: mdl-18033710