Polarized proton acceleration in ultraintense laser interaction with near-critical-density plasmas.

The production of polarized proton beams with multi-GeV energies in ultraintense laser interaction with targets is studied with three-dimensional particle-in-cell simulations. A near-critical density plasma target with prepolarized proton and tritium ions is considered for the proton acceleration. The prepolarized protons are initially accelerated by laser radiation pressure before injection and further acceleration in a bubblelike wakefield. The temporal dynamics of proton polarization is tracked via the Thomas-Bargmann-Michel-Telegdi equation and it is found that the proton polarization state can be altered by both the laser field and the magnetic component of the wakefield. The dependence of the proton acceleration and polarization on the ratio of the ion species is determined and it is found that the protons can be efficiently accelerated as long as their relative fraction is less than 20%, in which case the bubble size is large enough for the protons to obtain sufficient energy to overcome the bubble injection threshold.

High-quality high-order harmonic generation through preplasma truncation.

By introducing preplasma truncation to cases with an initial preplasma scale length larger than 0.2λ, the efficiency of high-order harmonics generated from relativistic laser-solid interactions can be enhanced by more than one order of magnitude and the angular spread can be confined into near-diffraction-limited divergence. Numerical simulations show that density truncation results in more compact oscillation of the surface electron sheet and the curvature of the reflection surface for the driving laser is greatly reduced. This leads to an overall improvement in the harmonic beam quality. More importantly, density truncation makes the harmonic generation weakly dependent on the preplasma scale length, which provides a way to relax the extremely high requirement on the temporal contrast of the driving laser pulse. A feasible scheme to realize the required preplasma truncation is also proposed and demonstrated by numerical simulations.

Multistage Coupling of Laser-Wakefield Accelerators with Curved Plasma Channels.

Multistage coupling of laser-wakefield accelerators is essential to overcome laser energy depletion for high-energy applications such as TeV-level electron-positron colliders. Current staging schemes feed subsequent laser pulses into stages using plasma mirrors while controlling electron beam focusing with plasma lenses. Here a more compact and efficient scheme is proposed to realize the simultaneous coupling of the electron beam and the laser pulse into a second stage. A partly curved channel, integrating a straight acceleration stage with a curved transition segment, is used to guide a fresh laser pulse into a subsequent straight channel, while the electrons continue straight. This scheme benefits from a shorter coupling distance and continuous guiding of the electrons in plasma while suppressing transverse beam dispersion. Particle-in-cell simulations demonstrate that the electron beam from a previous stage can be efficiently injected into a subsequent stage for further acceleration while maintaining high capture efficiency, stability, and beam quality.

A compact tunable polarized X-ray source based on laser-plasma helical undulators.

Laser wakefield accelerators have great potential as the basis for next generation compact radiation sources because of their extremely high accelerating gradients. However, X-ray radiation from such devices still lacks tunability, especially of the intensity and polarization distributions. Here we propose a tunable polarized radiation source based on a helical plasma undulator in a plasma channel guided wakefield accelerator. When a laser pulse is initially incident with a skew angle relative to the channel axis, the laser and accelerated electrons experience collective spiral motions, which leads to elliptically polarized synchrotron-like radiation with flexible tunability on radiation intensity, spectra and polarization. We demonstrate that a radiation source with millimeter size and peak brilliance of 2 × 10(19) photons/s/mm(2)/mrad(2)/0.1% bandwidth can be made with moderate laser and electron beam parameters. This brilliance is comparable with third generation synchrotron radiation facilities running at similar photon energies, suggesting that laser plasma based radiation sources are promising for advanced applications.

Dense blocks of energetic ions driven by multi-petawatt lasers.

Laser-driven ion accelerators have the advantages of compact size, high density, and short bunch duration over conventional accelerators. Nevertheless, it is still challenging to simultaneously enhance the yield and quality of laser-driven ion beams for practical applications. Here we propose a scheme to address this challenge via the use of emerging multi-petawatt lasers and a density-modulated target. The density-modulated target permits its ions to be uniformly accelerated as a dense block by laser radiation pressure. In addition, the beam quality of the accelerated ions is remarkably improved by embedding the target in a thick enough substrate, which suppresses hot electron refluxing and thus alleviates plasma heating. Particle-in-cell simulations demonstrate that almost all ions in a solid-density plasma of a few microns can be uniformly accelerated to about 25% of the speed of light by a laser pulse at an intensity around 10(22) W/cm(2). The resulting dense block of energetic ions may drive fusion ignition and more generally create matter with unprecedented high energy density.

Synaptic plasticity deficits in an experimental model of rett syndrome: long-term potentiation saturation and its pharmacological reversal.

Rett syndrome (RTT), a disorder caused almost exclusively by mutations in the X-linked gene, MECP2, has a phenotype thought to be primarily of neurological origin. Disruption of Mecp2 in mice results in a prominent RTT-like phenotype. One of the consequences of MeCP2 absence in the brain is altered functional and structural plasticity. We aimed to characterize synaptic effects related to plasticity in the hippocampus further and establish whether plasticity defects are amenable to pharmacological reversal. Using male mice in which Mecp2 expression was prevented by a stop cassette, we assessed synaptic plasticity in area CA1 at different phenotypic stages, scoring the mice weekly for overt RTT-like signs. Strongly symptomatic Mecp2(stop/y) mice displayed reduced long-term potentiation (LTP, 40.2±1.6% of wild-type), post-tetanic potentiation (PTP, 45±18.8% of wild-type) and paired-pulse facilitation (PPF, 78±0.1% of wild type) (all P<0.05), the impairment increasing with symptom severity score. These plasticity impairments were absent in presymptomatic mice. Repeated high frequency stimulation revealed pronounced LTP saturation in symptomatic Mecp2(stop/y) mice, suggesting an LTP 'ceiling' effect. Bath application of the weak NMDA receptor blocker memantine (1 µM) resulted in partial restoration of a short-term plasticity component. These data support that idea that progressive functional synaptic impairment is a key feature in the RTT brain and demonstrate the potential for the pharmacological restoration of plasticity function.

Plasma currents and electron distribution functions under a dc electric field of arbitrary strength.

The currents induced by arbitrarily strong dc electric fields in plasma and the evolution of electron distributions have been studied by Fokker-Planck simulations. We find that the electron distributions evolve distinctly under different fields; especially, the electron distribution is well represented by the sum of a stationary and drifting Maxwellian at the moderate field. A set of hydrodynamiclike equations, similar to Spitzer's but without the weak-field limit, is given for calculating the current. It is more suitable for application in hybrid particle-in-cell simulations and may extend plasma transport theory in models that do not employ a kinetic description of the electrons.

Antitumor effect of alpha isomer of anordrin in vitro and cell cycle arrest at G1 phase.

Alpha isomer of anordrin (2 alpha, 17 alpha-diethyl-A-norandrostane-2 beta, 17 beta-diol dipropionate, alpha-Ano) inhibited mouse hepatoma (Hep A) and P388 cell growth in vitro. alpha-Ano (20 micrograms.ml-1) inhibited the incorporation of [3H]uridine and [3H]thymidine into RNA and DNA within 3 h, but the inhibition of L-[3H]lysine incorporating into protein was not obvious. alpha-Ano had no effect on the DNA-dependent RNA synthesis with purified nuclei of Hep A cells. It is suggested that the inhibition of RNA and DNA syntheses is the major cause of the cytostatic effect. alpha-Ano blocked the P388 cells at G1/G0 phase, and the delay in G1/G0 to S phase transition plays an important role in the inhibition of P388 cell growth.