Effect of high-flux hemodialysis plus compound-α Ketoacid tablets under humanistic care on calcium-phosphorus metabolism in uremia patients.

Uremia (UR) is a terminal renal failure manifestation with a very high risk of death, high-flux hemodialysis (HFHD) is currently the most common treatment for UR in clinical practice. In this study, we analysed the therapeutic efficacy of HFHD plus Compound-α Ketoacid Tablets for UR under humanistic care. Firstly, we randomised 100 patients with UR into a research group (RG) for HFHD plus Compound-α Ketoacid Tablets therapy and a control group (CG) for HFHD treatment, with both therapies implemented under humanistic care. By way of comparison, we found that the study group had significantly better renal function after treatment and they had a lower inflammatory response. Also, the study group showed lower calcium and phosphorus metabolism and better immune function. Based on these results, we believe that HFHD + Compound-α Ketoacid Tablets under humanistic care have high clinical value.

Effects of High-flux Hemodialysis With Narrative Care on Clinical Efficacy and Prognostic Quality of Life of Patients With Chronic Renal Failure.

Context: Chronic renal failure (CRF) is the outcome of the continuous progression of various chronic kidney diseases. Effective treatment of a wide range of diseases may require decreasing patients' negative emotions and enhancing their disease resilience. Narrative care focuses on patients' inner awareness, feelings, and experience of a disease, stimulating positive energy in the face of it. Objective: The study intended to investigate the effects of using narrative care during high flux hemodialysis (HFHD) on clinical outcomes and prognosis of quality of life (QoL) for patients with chronic renal failure (CRF), to provide a reliable theoretical reference for future clinical treatment. Design: The research team performed a randomized controlled trial. Setting: The study took place at the Blood Purification Center at the Affiliated Hospital of Medical School at Ningbo University in Ningbo, Zhejiang, China. Participants: Participants were 78 patients with CRF who received treat with HFHD at the hospital between January 2021 and August 2022. Intervention: The research team divided participants into two groups using the random number table method, with 39 participants in each group: (1) and intervention group who received narrative nursing care and (2) a control group who receive the usual care. Outcome Measures: The research team: (1) evaluated the clinical efficacy for both groups; (2) at baseline and postintervention, measured participants' blood creatinine (SCr) and blood urea nitrogen (BUN) using blood sampling; (3) counted adverse effects; (4) investigated participants' nursing satisfaction postintervention; (5) at baseline and postintervention, assessed psychology and QoL using the Self-Assessment Scale for Anxiety (SAS), the Self-Assessment Scale for Depression (SDS), and the General Quality of Life Inventory (GQOLI-74) scale. Results: No statistically significant differences existed between the groups in terms of efficacy or renal function postintervention (P > .05). The incidence of adverse reactions was significantly lower in the intervention group than in the control group postintervention (P = .033), and the group's nursing satisfaction was significantly higher (P = .042). In addition, participants' SAS and SDS scores decreased significantly in the intervention group postintervention (P < .05), while no change occurred for the control group (P > .05). Finally, the GQOLI-74 scores were all significantly higher in the intervention group than in the control group. Conclusions: Narrative care can effectively enhance the safety of HFHD treatment in CRF patients and reduce patients' negative emotions postintervention, which is important for improving their QoL.

Impacts of Acupuncture Plus Acupoint Application on Intestinal Function and Expression of MAPK and ERK in Colon Tissue of Rats.

Context: Slow transit constipation (STC) has a high incidence worldwide, which not only seriously affects patients' normal lives but also may cause malignant intestinal lesions. Among the limited treatment options for STC, traditional Chinese medicine (TCM) is considered to be the key to STC treatment in the future. Objective: The study intended to examine the impacts of acupuncture plus acupoint application on MAPK and ERK in STC rats, with the aim of preliminarily exploring the relevant mechanisms for treating STC as well as providing new ideas and means for future clinical treatment. Design: The research team designed a randomized, controlled animal study. Setting: The study was carried out at department of Department of Rehabilitation, Affiliated Hospital of Medical School of Ningbo University, Ningbo, Zhejiang, China. Animals: The animals were 30 six-to-eight-week-old, Sprague Dawley (SD) rats, half male and half female and weighing a mean of 200 ± 20 g. Intervention: The rats were randomly assigned to one of three groups, 10 rats in each group: a negative control group that wasn't induced with STC and received no treatments; a positive control group, the model group (MG), that was induced with STC and received no treatments; and an intervention group that was induced with STC and received the investigated treatments. The intervention group was treated with acupuncture at Tianshu point (ST25) and received acupoint application from Chinese medicine. Outcome Measures: The study measured the alterations in the rats' body weight and feces, as well as the rats' intestinal motility, using intragastric administration of activated carbon. The rats were killed to obtain their intestinal tissues, for measuring expression of mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK) using Western blotting and polymerase chain reaction (PCR). Results: Postintervention, at 28 days after induction of STC, the rats' weights weren't significantly different in the intervention and control groups (P > .05) but were significantly higher than that in the model group (P < .05). The rats' weights in the intervention and control groups gradually increased significantly, while those in the model group gradually decreased significantly (P < .05). The defecation volume and fecal water content (FWS) decreased in the significantly model group but increased significantly in the intervention group (P < .05). The intestinal motility test revealed no significant differences in the propulsion rate between the intervention and control groups (P > .05), but the rate was significantly lower in the model group than that of the intervention group (P < .05). The intestinal fecal residue in the model group was the highest among the three groups, followed in descending order by the intervention group and the control group, with the differences being statistically significant (P < .05). In addition, the MAPK and ERK in the model group significantly increased, and the values were significantly higher in the intervention group than those of the model group (P < .05). Conclusions: Acupuncture plus acupoint application can validly improve the defecation and intestinal motility of STC rats, possibly through inhibiting MAPK and ERK.

Association between Triglyceride-Glucose Index and Type 2 Diabetes Mellitus in the Japanese Population: A Secondary Analysis of a Retrospective Cohort Study.

Triglyceride-glucose index (TyG index) is associated with type 2 diabetes mellitus (T2DM), but research on this relationship is limited in Japan. The purpose of this study was to evaluate the correlation between TyG index and the risk of T2DM in the Japanese population. Here, 12732 participants were selected from the NAGALA study (NAfld in the Gifu Area, Longitudinal Analysis) conducted between 2004 and 2015 for a retrospective cohort analysis. The association between TyG index and T2DM was assessed using the Cox proportional-hazard model. Subgroup analyses were conducted according to age, sex, smoking status, alcohol consumption, waist circumference, BMI, and follow-up duration. The formula for TyG index was expressed as ln [fasting triglyceride level (mg/dL) × fasting plasma glucose level (mg/dL)/2]. After follow-up, 150 (1.18%) patients developed T2DM. After adjusting for potential confounders, a linear relationship was observed between TyG and the risk of T2DM. After adjusting for age, sex, BMI, waist circumference, HDL-cholesterol, total cholesterol, systolic blood pressure, regular exercise, smoking status, and alcohol consumption, TyG index, as a continuous variable, was associated with an increased risk of T2DM (adjusted hazard ratio (aHR), 1.79; 95% confidence interval (95% CI), 1.25-2.57). Compared with the first quartile of TyG index, subjects in the fourth quartile were 2.33-fold more likely to develop T2DM (aHR 2.33, 95% CI 1.09-4.96; P for trend 0.0224). Subgroup analyses showed that the association between TyG index and incident T2DM stably existed in different subgroups according to the variables tested. Therefore, TyG index was linearly related to the risk of incident T2DM in the Japanese population and may be used as a monitoring tool.