Effects of glutamine dipeptide on myocardial injury and left ventricular systolic function after car-diac surgery / 临床外科杂志

Objectives To investigate the effects of glutamine dipeptide on myocardial injury andleft ventricular systolic function after cardiac surgery.Method A total of 60 patients who underwent cardiac surgery with cardiopulmonary bypass(CPB)were randomized into two groups(n =30 in each).Thestudy group received intravenous administration of glutamine dipeptide for 7 days and the control group received compound amino acids as controls.Hemodynamic variations,peak systolic myocardial velocity(Sa)of the mitral annulus,serum troponin T(TnT),mechanical ventilation duration and ICU hospitalizationwere recorded and compared between groups.Results There were no significant differences in hemodynamic variations and left ventricular ejection fraction(LVEF).In the study group,the level of serum TnTdecreased significantly within 12 and 24 hours after glutamine administration(P <0.05),and Sa improvedsignificantly on the third day(P <0.05).No significant differences were found in mechanical ventilationduration and ICU hospitalization.Conclusion Intravenous administration of glutamine dipeptide has cardioprotective effects in patients after cardiac surgery,which may improve myocardial injury and speed systolic function recovery.