Status of non-suicidal self-injury among middle school students in Zhuang nationality and its association with internet addiction / 中国学校卫生

Objective@#To understand the status of non-suicidal self-injury (NSSI) among Zhuang middle school students and its association with internet addiction, and to provide support for the effective prevention of unhealthy behaviors among Zhuang middle school students.@*Methods@#From March to June 2018, 14 822 Zhuang middle school students were selected from 8 cities in Guangxi to conduct a questionnaire survey, including demographic information, family status, NSSI, internet addiction, and psychological status.@*Results@#The proportion of NSSI among middle school students in Zhuang nationality was 30.54%; the proportion of occasional and frequent NSSI was 18.24% and 12.30%, respectively. The proportion of Zhuang middle school students with internet addiction was 1.82%, and those with suspected Internet addiction was 29.77%. Non-suicidal self-injury behaviors were statistically significant in different grades, whether the only-child in the family, family income, family type, parenting style, family history of mental illness, and Internet addiction(χ2=5.67, 34.25, 73.39, 16.12, 116.71, 10.66, 294.48, P<0.05). Regression analysis showed that middle school students (OR=0.53) and non-only children (OR=0.79) were more likely to have non-suicidal self-injury behaviors. Family income ≥5 000 yuan per month(OR=1.49), joint family(OR=1.98), intergenerational family(OR=1.30), education method with neglect(OR=1.35), family history of mental illness(OR=1.29), suspected internet addiction(OR=1.65), and internet middle school students with an addiction(OR=1.96) were more likely to have non-suicide suicide.@*Conclusion@#Zhuang middle school students have serious non-suicide suicide behaviors, which is closely associated with internet addiction. In the future, non-suicide suicide behaviors can be reduced through internet addiction prevention.

Lab-on-a-chip technologies for genodermatoses: Recent progress and future perspectives.

In recent years, molecular biology has proven to be a great asset in our understanding of mechanisms in genodermatoses. However, bench to bedside translation research lags far behind. Advances in lab-on-a-chip technologies enabled programmable, reconfigurable, and scalable manipulation of a variety of laboratory procedures. Sample preparation, microfluidic reactions, and continuous monitoring systems can be integrated on a small chip. These advantages have attracted attention in various fields of clinical application including diagnosis of inherited skin diseases. This review lists an overview of the underlying genes and mutations and describes prospective application of lab-on-a-chip technologies as solutions to challenges for point-of-care genodematoses diagnosis.

Protection Effects of Metformin Combined with Calcitriol on Renal Function and Retina in Patients with Type 2 Diabetes / 中国药房

OBJECTIVE:To observe the protection effects of Metformin combined with Calcitriol on renal functiou and retina in patients with type 2 diabetes. METHODS:80 patients with type 2 diabetes with early diabetic nephropathy and mild-to-moderate non proliferative retinopathy were randomly divided into control group(40 cases)and observation group(40 cases). Control group received Metformin hydrochloride tablet with initial dose of 0.5 g,twice a day during a meal,increased 0.5 g every week,then gradually increased to 2 g every day;observation group additionally received Calcitriol soft capsule,0.25 μg/times,once a day. The treatment lasted and followed-up for 6 months. Efficacy of retinopathy,blood glucose levels [2 h postprandial blood glucose (2 h PG),blood glucose (FPG)],renal function indexes [urinary albumin-to-creatinine ratio (ACR),urinary albumin excretion rate (UAER),proteinuria (Pr)],vision and visual field defects,fundus angiography before and after treatment,and the incidence of adverse reactions in 2 groups were observed. RESULTS:The total effective rate in observation group was significantly higher than in control group,and the difference was statistically significant(P0.05). After treatment,2 h PG, FPG were significantly lower than before;ACR,Pr,UAER,average value of visual field defects,fundus angiography and bleed-ing area were significantly lower than before,and observation group was lower than control group;vision was significantly higher than before,and observation group was higher than control group. The differences were statistically significant (P<0.05). There was respectively 1 patient showed slight adverse reactions in both groups. CONCLUSIONS:Metformin combined with Calcitriol has certain protection effect on the renal function and retina in patients with type 2 diabetes,it can reduce 2 h PG,FPG,ACR, Pr,UAER,average value of visual field defects,fundus angiography and bleeding area of patients and improve vision,with small adverse reactions and high safety.