ABSTRACT
Objective To explore the pharmacokinetic characteristics of telmisartan in Chinese healthy volunteers. Methods 9 Chinese male healthy volunteers were divided into receiving orally a single dose of 40, 80, 120 mg telmisartan tablets respectively, in latin square design study. After administration of telmisartan tablets, the plasma concentration was determined by HPLC with fluorescent detection. The pharmacokinetic parameters were analyzed by 3P97 program. Results It was found that plasma levels increased after orally increased dosages of telmisartan in the healthy volunteers in a nor-dose-dependent manner. The pharmacokinetic parameters were calculated the follows: AUC 0-96 of three different dosages (40, 80,120 mg) were (895.03?364.53), ( 3 030.34? 1 454.80) and ( 13 570.44? 3 551.54) ?g?h -1?L -1; and C max were (60.71?28.10), (214.05?74.14) and (978.32?234.89) ?g?L -1. There were significant differences in AUC 0-t/dose, C max/dose between the groups (P
