ABSTRACT
The effects of cessation of i.v. drug use on CD4 lymphocyte count and serum levels of beta2 -microglobulin (beta2 m) and soluble interleukin-2 receptor (sIL-2R) were prospectively investigated in 41 HIV-positive drug users enrolled in a methadone treatment programme. Fifteen HIV-positive matched non-abstainers served as controls. During the follow-up of 12 months the mean CD4 lymphocyte count remained unchanged in the methadone-treated group but fell significantly in controls. beta2 m and sIL-2R values decreased in abstainers at the beginning of the treatment but rose in non-abstaining group. We conclude that cessation of illicit drug abuse and methadone treatment in HIV-infected injecting drug users may exert a beneficial effect on the immune status.
ABSTRACT
The presence of serum autoantibodies directed against single-stranded DNA (ssDNA), RNA, histones, nuclear antigen SS-A, mitochondria and cardiolipin were investigated in 30 HIV-negative drug addicts (from years 1986-87), 30 addicts actually infected with HIV and 31 AIDS patients presenting with clinical symptoms indicating autoimmune disorders. Positive results were found in 12 (40%) drug addicts from years 1986-87, 5 (16.7%) actually infected and 16 (51.6%) AIDS patients. Autoantibodies were more often detectable in patients with thrombocytopenia 8/12 (66.7%) than in remaining 8 out of 19 subjects (42.1%) who presented dermatitis, hepatitis, pancarditis, ulcerative colitis and polyneuropathy. The prevalence of autoantibodies in all investigated groups were significantly higher than in controls-1/20 (3.3%).
Subject(s)
Acquired Immunodeficiency Syndrome/immunology , Autoantibodies/blood , RNA, Small Cytoplasmic , Adult , Autoantigens/immunology , Cardiolipins/immunology , DNA, Viral/immunology , Female , Humans , Male , Middle Aged , Mitochondria/immunology , RNA, Viral/immunology , Ribonucleoproteins/immunologyABSTRACT
The effect of discontinuation of injecting drug use and administration of methadone was investigated in 43 HIV-infected drug abusers. In 20 (46.5%) out to them an improvement in the immune status as measured by CD4+ lymphocyte percentage and CD4/CD8 lymphocyte ratio was observed, while remaining 23 persons (53.5%) showed stable or decreasing values of both parameters. In the control group which consisted of 23 persons who continued injecting drug use, only 3 (13%) out of the showed increase in the CD4+ lymphocyte percentage and CD4/CD8 lymphocyte ratio. It seems that discontinuation of injecting drug use may improve the function of immune system in HIV-infected drug addicts and could be an important factor in the approach for treatment of these patients.
Subject(s)
HIV Infections/immunology , Heroin Dependence/drug therapy , Methadone/administration & dosage , Narcotics/administration & dosage , Substance-Related Disorders/complications , Substance-Related Disorders/prevention & control , Adult , CD4-CD8 Ratio , Female , Humans , MaleABSTRACT
Prevalence of markers of HBV infection was tested in two cohorts of drug addicts: in 140 addicts whose sera were drawn in the years 1985-1986 and in 100 addicts whose sera were drawn in the years 1988-1989. HBsAg was found in 10 (7%) patients in the earlier cohort and in 12 (12%) addicts in the latter, while at least one marker of HBV infection was present in 39% and 69%, respectively No correlation was found between the presence of markers of HBV infection and age, gender, or HIV status, however, duration of drug abuse increased the risk of HBV infection. There was no difference in mean titres of anti-CMV and anti-HSV-1 between subjects with and without HBV markers what suggests that the tested markers were specific.
Subject(s)
Acquired Immunodeficiency Syndrome/immunology , Hepatitis B Antibodies/analysis , Hepatitis B virus/immunology , Hepatitis B/immunology , Opportunistic Infections/immunology , Substance-Related Disorders/immunology , Acquired Immunodeficiency Syndrome/complications , Adult , Biomarkers/blood , Female , Hepatitis B/etiology , Hepatitis B Antibodies/immunology , Hepatitis B Core Antigens/analysis , Hepatitis B Core Antigens/immunology , Hepatitis B Surface Antigens/analysis , Hepatitis B Surface Antigens/immunology , Hepatitis B e Antigens/analysis , Hepatitis B e Antigens/immunology , Humans , Male , Opportunistic Infections/etiology , Poland , Substance-Related Disorders/complicationsABSTRACT
The prevalence of anti-HCV and serological markers of HBV infection was tested in 100 unselected intravenous drug addicts admitted to a detoxification ward. Anti-HCV were present in 78% addicts, and at least one markers of HBV infection was present in 69% addicts. No correlation was found between anti-HCV status and age, gender, duration of addiction or anti-HIV presence. Furthermore, there was no difference in mean titres of anti-CMV and anti-HSV between subjects with and without anti-HCV what suggests that the anti-HCV tested were specific.
