ABSTRACT
OBJECTIVES: Epithelioid rhabdomyosarcoma (EpiRMS) is a novel morphologically distinct variant of rhabdomyosarcoma, with an unusually challenging microscopic diagnosis. The occurrence of rhabdomyosarcomas in the jaws is extremely rare. This study presents the first case of EpiRMS in the jaw (mandible) and a literature review of the previous 35 cases of EpiRMS. STUDY DESIGN: Here, we report a case of EpiRMS affecting an 18-year-old male patient. Clinical, imaging, microscopic, and immunohistochemical features are discussed and previously reported cases of EpiRMS are reviewed. RESULTS: An 18-year-old male patient presented with an exophytic sessile growth on the buccal gingiva, and orthopantomography revealed irregular bone loss. Microscopic analysis showed a large number of cells with epithelioid appearance. Immunohistochemistry staining was positive for desmin, myogenin, MyoD1, smooth muscle actin, h-caldesmon, INI-1, and AE1-AE3. The patient's disease was staged as T4aN1M0 and was treated with surgical excision combined with chemotherapy. CONCLUSIONS: The occurrence of RMS in the mandible is rare, and this is the first case of EpiRMS in the jaw. EpiRMS is an unusual histologic subtype that mimics other sarcomas and epithelial malignancies, making diagnosis a challenge. A specific immunohistochemistry panel aids in the diagnosis. EpiRMS has an aggressive course and an unfavorable prognosis.
Subject(s)
Rhabdomyosarcoma , Soft Tissue Neoplasms , Adolescent , Biomarkers, Tumor , Humans , Immunohistochemistry , Male , Myogenin , Rhabdomyosarcoma/surgeryABSTRACT
ABSTRACT An unusual case of parasitism by Lagochilascaris minor infection is reported in a 38-year-old woman from Paraupebas, Pará, Brazil. The article summarizes the main characteristics of the disease and its etiological agent, including prevalence, life cycle, clinical course and treatment.
RESUMO Relata-se um caso de infecção por Lagochilascaris minor, parasitose incomum, em mulher de 38 anos de idade, procedente de Paraupebas, Pará, Brasil. O artigo resume as principais características da doença e de seu agente etiológico, incluindo prevalência, ciclo de vida, curso clínico e tratamento.
ABSTRACT
Introdução: Os schwanomas são tumores raros que podemse originar de qualquer nervo periférico, cranial ou autonômico,sendo que cerca de 45% deles estão localizados na cabeça e/ou no pescoço. Podem ser únicos, múltiplos (neurofibromas),benignos e até malignizarem. Objetivo: relatar um caso deexérese transoral com boa evolução pós-operatória. Relato deCaso: paciente jovem com abaulamento faríngeo submetidoà ressecção transoral de schwannoma sem sequelas oucomplicações. Comentários finais: O diagnóstico baseia-se nahistória clínica, no exame físico e em exames complementarescomo a Ressonância Nuclear Magnética (RNM) e PAAF. O únicotratamento curativo é a excisão cirúrgica, embora o seguimentoeventualmente seja necessário.
