ABSTRACT
The authors describe their cooperation in the diagnosis and treatment of a newborn with malignant brain tumour (rare case of carcinoma of the choroid plexus) recognised by means of prenatal sonography and magnetic resonance. The case history is an example of modern algorithm of diagnostic and therapeutic procedures in perinatal medicine and the necessary multicentre collaboration.
Subject(s)
Carcinoma/diagnosis , Choroid Plexus Neoplasms/diagnosis , Fetal Diseases/diagnosis , Prenatal Diagnosis , Adult , Algorithms , Carcinoma/surgery , Choroid Plexus Neoplasms/surgery , Fatal Outcome , Female , Fetal Diseases/surgery , Humans , Infant, Newborn , Magnetic Resonance Imaging , Pregnancy , Tomography, X-Ray ComputedABSTRACT
Diagnostic imaging has determined clinical application depending on kind of pathology and anatomical localisation. This is a precise and fine instrument for monitoring effects of treatment in childhood malignant tumours. Authors demonstrate examples of cases in which diagnostic imaging was the only method which revealed a relapse in situ, progression during chemotherapy or clinically unsuspected dissemination of tumours after many years.
Subject(s)
Abdominal Neoplasms/diagnosis , Bone Neoplasms/diagnosis , Diagnostic Imaging/methods , Fibromatosis, Aggressive/diagnosis , Neoplasm Recurrence, Local/diagnosis , Osteosarcoma/diagnosis , Rhabdomyosarcoma, Embryonal/diagnosis , Abdominal Neoplasms/therapy , Adolescent , Bone Neoplasms/therapy , Carcinoma in Situ/diagnosis , Child, Preschool , Cicatrix/diagnosis , Diagnosis, Differential , Female , Fibromatosis, Aggressive/therapy , Follow-Up Studies , Humans , Lung Neoplasms/diagnosis , Lung Neoplasms/secondary , Lymphatic Metastasis , Male , Osteosarcoma/therapy , Rhabdomyosarcoma, Embryonal/therapy , Urinary Bladder Neoplasms/diagnosisABSTRACT
A five-year-old girl with portal vein thrombosis and severe gastrointestinal hemorrhage recurring after repeated endoscopic sclerotherapy was successfully embolized via an ultrasonically guided transsplenic catheterization of the splenic vein.
Subject(s)
Embolization, Therapeutic , Esophageal and Gastric Varices/therapy , Gastrointestinal Hemorrhage/therapy , Catheterization/methods , Child, Preschool , Female , Hepatic Veno-Occlusive Disease/complications , Humans , Splenic VeinABSTRACT
A 30-month-old boy with severe psychomotor retardation and numerous developmental anomalies, such as small trigonocephalic head, craniofacial anomalies, malformations of fingers with hypoplastic thumbs, anomalies of urogenital organs and imperforate anus, is presented. Cytogenetic studies of peripheral blood lymphocytes with differential staining of chromosomes revealed 46,XY,r13 karyotype. The correlation between clinical features and the observed chromosome aberration is discussed. Hitherto unreported developmental brain anomalies with partial exhibited skeletal abnormalities, some not reported previously.
Subject(s)
Abnormalities, Multiple/genetics , Chromosome Aberrations , Chromosomes, Human, 13-15 , Psychomotor Disorders/genetics , Ring Chromosomes , Agenesis of Corpus Callosum , Child, Preschool , Chromosome Banding , Facial Bones/abnormalities , Humans , Karyotyping , Lymphocytes/ultrastructure , Male , Muscle Hypotonia/genetics , Phenotype , SyndromeABSTRACT
Partial trisomy of the long arm of the chromosome 17 was found in a male infant with severe psychomotor retardation and numerous developmental anomalies. Differential staining with GTG, QFQ and CBG methods revealed an excess of genetic material on the short arm of chromosome 14, which was preliminarily identified as the distal part of chromosome 17q. Using an automatic picture analyser, chromosome break points were found in the 17q12 and 14p12 bands. The patient's karyotype was identified as 46,XY,t(14;17) (14qter----14p12:17q12----17qter).
Subject(s)
Abnormalities, Multiple/genetics , Chromosomes, Human, 16-18 , Psychomotor Disorders/genetics , Trisomy , Chromosome Banding , Densitometry , Humans , Infant , Karyotyping , Lymphocytes/ultrastructure , MaleABSTRACT
A case of intestinal obstruction, as a result of radiation injury of the colon, is reported. This child was treated by roentgen therapy in the infant period because of a Wilms' tumour of the left kidney.
Subject(s)
Intestinal Obstruction/etiology , Kidney Neoplasms/radiotherapy , Radiotherapy/adverse effects , Wilms Tumor/radiotherapy , Child , Colon/radiation effects , Colon/surgery , Humans , Intestinal Obstruction/surgery , MaleABSTRACT
Current surgical methods enable radical treatment of the most bulboventricular malformations (syn. conotruncal malformations, transposition complex). The defects, which were until now the field of embryologist and pathologist, require accurate and precise clinical diagnosis of the anomaly. The purpose of this analysis was to estimate the ability of angiocardiography for diagnosis of bulboventricular malformations considering the type of essential anomaly, its exact morphology and character of coexisting malformations. The report represents 49 cases with pathological diagnosis of bulboventricular malformations in children, in which during hospitalization angiocardiography has been performed. The cases were selected from 1918 angiocardiographies and also from 987 cases of pathological specimens with congenital heart diseases in the years 1970-1977. There were: 33 cases of TGA, in these 2 with corrected TGA, 3 cases of DORV, 1 case of DOLV , 12 cases of CV. All cases showed the broad spectrum of variants in position of the great arteries and kind of conus apart from type of basic anomaly. Septal defects, pulmonary orifice stenosis or atresia and anomalies of atrio-ventricular orifices particularly in common ventricle were mostly coexisting malformations. To recognize essential anomaly we estimated atrio-ventricular and ventriculo-arterial relation (connection), based on Kirklin classification. The conuses and position of the trunk of the great arteries were treated as pathomorphologic details, that had no influence on essential diagnosis of malformation. Arbitrary accepted definition and nomenclature was based on data from bibliography. Angiocardiography was made using full-size filmchanger AOT with maximal frequency 6 frames/sec. Contrast medium injected mainly into the ventricles. X-rays were performed usually immediately in two projections. Comparison of the angiocardiographic diagnosis with pathology of the hearts showed the correct diagnosis of the essential malformation, by means of angiocardiography, in more than 80% cases. But the diagnosis percentage in particular elements of malformation varied from 2/3 to 1/3 according to the type of malformation. The absence of the correct diagnosis of the essential anomaly, based on type of relations, was the lack of visualization of all heart cavities (in some cases), which was conditioned by the method. On the other hand the correct angiocardiographic diagnosis was sometimes impossible, because of very complicated anatomical situation in malformed hearts.(ABSTRACT TRUNCATED AT 400 WORDS)
