1.
Org Biomol Chem
; 5(1): 61-4, 2007 Jan 07.
Article
in English
| MEDLINE
| ID: mdl-17164907
ABSTRACT
A highly effective one-pot Friedländer quinoline synthesis using inexpensive reagents has been developed. o-Nitroarylcarbaldehydes were reduced to o-aminoarylcarbaldehydes with iron in the presence of catalytic HCl (aq.) and subsequently condensed in situ with aldehydes or ketones to form mono- or di-substituted quinolines in high yields (66-100%).
Subject(s)
Aldehydes/chemistry , Benzaldehydes/chemistry , Quinolines/chemical synthesis , Iron/chemistry , Ketones/chemistry , Molecular Structure , Oxidation-Reduction , Quinolines/chemistry
2.
Bioorg Med Chem Lett
; 17(4): 1091-7, 2007 Feb 15.
Article
in English
| MEDLINE
| ID: mdl-17127062
ABSTRACT
A series of novel 8-amino-1,3-disubstituted-imidazo[1,5-a]pyrazines was designed and synthesized as IGF-IR inhibitors.
