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1.
Sci Rep ; 14(1): 1978, 2024 01 23.
Article in English | MEDLINE | ID: mdl-38263185

ABSTRACT

Opioid use is only recommended in selected cases of musculoskeletal (MSK) injuries. We assessed factors associated with increased opioid use in MSK injuries. In a retrospective analysis of over four million workers with MSK injuries using the Swiss National Accident Insurance Fund (Suva) database, we analyzed risk factors by multivariate logistic regression. Injury severity was associated with pain medication, opioid, and strong opioid use. Whereas fractures, contusions, and ruptures had higher odds for any pain medication use, increased odds for strong opioids were observed in fractures, superficial injuries, and other injuries. Injuries of the shoulders, elbow, chest, back/spine, thorax, and pelvis/hips showed high odds for opioid use (odds ratio (OR) > 2.0). Injuries of the shoulders had higher odds for strong opioid use (OR 1.136; 95% CI 1.040-1.241). The odds for using strong opioids increased from 2008 OR 0.843 (95% confidence interval (CI) 0.798-0.891) to 2018 OR 1.503 (95% CI 1.431-1.578), compared to 2013. Injury severity, type of injury, and injured body parts influenced the use of pain medication and overall opioid use in musculoskeletal injuries. Strong opioids were more often used in fractures but also in superficial and other minor injuries, which indicates that other factors play a role when prescribing strong opioids.


Subject(s)
Fractures, Bone , Insurance , Opioid-Related Disorders , Humans , Analgesics, Opioid , Retrospective Studies , Pain
2.
Pain Med ; 24(9): 1066-1072, 2023 09 01.
Article in English | MEDLINE | ID: mdl-37154698

ABSTRACT

OBJECTIVE: To assess the degree of resilience in patients with complex regional pain syndrome (CRPS) 1, to explore the relationship between resilience and patient-related outcome measurements and to describe a pattern of clinical manifestations associated with low resilience. METHODS: This study presents a cross-sectional analysis of baseline information collected from patients enrolled in a single center study between February 2019 and June 2021. Participants were recruited from the outpatient clinic of the Department of Physical Medicine & Rheumatology of the Balgrist University Hospital, Zurich, Switzerland. We used linear regression analysis to explore association of resilience with patient reported outcomes at baseline. Furthermore, we explored the impact of significant variables on the low degree resilience using logistic regression analysis. RESULTS: Seventy-one patients (females 90.1%, mean age 51.2 ± 12.9 years) were enrolled. There was no association between CRPS severity and the level of resilience. Quality of Life was positively correlated with resilience, as was pain self-efficacy. Pain catastrophizing was inversely correlated with the level of resilience. We observed a significant inverse association between anxiety, depression and fatigue and the level of resilience. The proportion of patients with a low resilience increased with higher level of anxiety, depression and fatigue on the PROMIS-29, without reaching statistical significance. CONCLUSION: Resilience seems to be an independent factor in CRPS 1 and is associated with relevant parameters of the condition. Therefore, caretakers may screen the current resilience status of CRPS 1 patients to offer a supplementary treatment approach. Whether specific resilience training modifies CRPS 1 course, requires further investigations.


Subject(s)
Complex Regional Pain Syndromes , Reflex Sympathetic Dystrophy , Female , Humans , Adult , Middle Aged , Cross-Sectional Studies , Quality of Life , Pain Measurement , Cohort Studies , Fatigue
3.
Am J Med ; 133(1): 60-72.e14, 2020 01.
Article in English | MEDLINE | ID: mdl-31278933

ABSTRACT

BACKGROUND: Very little evidence is available on the prevalence of serious spinal pathologies and the diagnostic accuracy of red flags in patients presenting to the emergency department (ED). This systematic review aims to investigate the prevalence of serious spinal pathologies and the diagnostic accuracy of red flags in patients presenting with low back pain to the ED. METHODS: We systematically searched MEDLINE, PUBMED, EMBASE, Cochrane Library, and SCOPUS from inception to January 2019. Two reviewers independently reviewed the references and evaluated methodological quality. RESULTS: We analyzed 22 studies with a total of 41,320 patients. The prevalence of any requiring immediate/urgent treatment was 2.5%-5.1% in prospective and 0.7%-7.4% in retrospective studies (0.0%-7.2% for vertebral fractures, 0.0%-2.1% for spinal cancer, 0.0%-1.9% for infectious disorders, 0.1%-1.9% for pathologies with spinal cord/cauda equina compression, 0.0%-0.9% for vascular pathologies). Examples of red flags which increased the likelihood for a serious condition were suspicion or history of cancer (spinal cancer); intravenous drug use, indwelling vascular catheter, and other infection site (epidural abscess). CONCLUSION: We found a higher prevalence of serious spinal pathologies in the ED compared to the reported prevalence in primary care settings. As the diagnostic accuracy of most red flags was reported only by a single study, further validation in high-quality prospective studies is needed.


Subject(s)
Cauda Equina Syndrome/epidemiology , Epidural Abscess/epidemiology , Low Back Pain/etiology , Spinal Cord Compression/epidemiology , Spinal Fractures/epidemiology , Spinal Neoplasms/epidemiology , Catheters, Indwelling , Cauda Equina Syndrome/complications , Cauda Equina Syndrome/diagnosis , Emergency Service, Hospital , Epidural Abscess/complications , Epidural Abscess/diagnosis , Humans , Prevalence , Risk Factors , Spinal Cord Compression/complications , Spinal Cord Compression/diagnosis , Spinal Fractures/complications , Spinal Fractures/diagnosis , Spinal Neoplasms/complications , Spinal Neoplasms/diagnosis , Substance Abuse, Intravenous , Vascular Access Devices
4.
Pain Med ; 20(8): 1559-1569, 2019 08 01.
Article in English | MEDLINE | ID: mdl-30848817

ABSTRACT

OBJECTIVE: First, to determine the number of accident-related complex regional pain syndrome (CRPS) cases from 2008 to 2015 and to identify factors associated with an increased risk for developing CRPS. Second, to analyze the duration of work incapacity and direct health care costs over follow-up periods of two and five years, respectively. DESIGN: Retrospective data analysis. SETTING: Database from the Statistical Service for the Swiss National Accident Insurances covering all accidents insured under the compulsory Swiss Accident Insurance Law. SUBJECTS: Subjects were registered after an accident between 2008 and 2015. METHODS: Cases were retrospectively retrieved from the Statistical Service for the Swiss National Accident Insurances. Cases were identified using the appropriate International Classification of Diseases, 10th Revision, codes. RESULTS: CRPS accounted for 0.15% of all accident cases. Age, female gender (odds ratio [OR] = 1.53, 95% confidence interval [CI] = 1.47-1.60), and fracture of the forearm (OR = 38, 95% CI = 35-42) were related to an increased risk of developing CRPS. Over five years, one CRPS case accumulated average insurance costs of $86,900 USD and treatment costs of $23,300 USD. Insurance costs were 19 times and treatment costs 13 times the average costs of accidents without CPRS. Within the first two years after the accident, the number of days lost at work was 20 times higher in patients with CRPS (330 ± 7 days) than in patients without CRPS (16.1 ± 0.1 days). Two-thirds of all CRPS cases developed long-term work incapacity of more than 90 days. CONCLUSION: CRPS is a relatively rare condition but is associated with high direct health care costs and work incapacity.


Subject(s)
Accidents , Complex Regional Pain Syndromes/economics , Cost of Illness , Employment , Health Care Costs , Health Expenditures , Return to Work , Adolescent , Adult , Age Factors , Aged , Aged, 80 and over , Arm Injuries/economics , Arm Injuries/epidemiology , Child , Child, Preschool , Complex Regional Pain Syndromes/epidemiology , Complex Regional Pain Syndromes/physiopathology , Female , Forearm Injuries/economics , Forearm Injuries/epidemiology , Fractures, Bone/economics , Fractures, Bone/epidemiology , Humans , Infant , Infant, Newborn , Insurance, Accident , Joint Dislocations/economics , Joint Dislocations/epidemiology , Leg Injuries/economics , Leg Injuries/epidemiology , Logistic Models , Male , Middle Aged , Multivariate Analysis , Retrospective Studies , Risk Factors , Sex Factors , Switzerland/epidemiology , Work Capacity Evaluation , Young Adult
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